Methanandamide blocks amphetamine-induced behavioral sensitization in rats

Rasmussen, Bruce A.; Unterwald, Ellen M.; Kim, Jae K.

doi:10.1016/j.ejphar.2009.10.059

Cited by 4 publications

(3 citation statements)

References 54 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The development of cross-sensitisation to Met by methanandamide pre-treatment was clearly observed in our previous studies (Landa et al 2006a,b). On the other hand, methanandamide was reported to produce no changes in locomotor activities and to block amphetamine-induced behavioural sensitisation in rats (Rasmussen 2010). A decrease in locomotion after acute methanandamide treatment was observed in rats (Landa et al 2008) while in mice the drug did not change locomotor behaviour (Landa 2006a).…”

Section: Discussionmentioning

confidence: 97%

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Landa¹,

Šlais²,

Máchalová³

et al. 2014

Vet. Med. - Czech

View full text Add to dashboard Cite

ABSTRACT:The psychostimulant methamphetamine (Met), similarly to other drugs of abuse, is known to produce an increased behavioural response after its repeated application (behavioural sensitisation). It has also been described that an increased response to a drug may be elicited by previous repeated administration of another drug (cross-sensitisation). We have previously shown that the CB 1 , CB 2 and TRPV (vanilloid) cannabinoid receptor agonist methanandamide, cross-sensitised to Met stimulatory effects in mice. The present study was focused on ability of the more selective and potent CB 1 receptor activator arachidonylcyclopropylamide (ACPA) to elicit cross-sensitisation to the stimulatory effects of Met on mouse locomotor behaviour in the Open field test. Male mice were randomly divided into three groups and on seven occasions (from the 7 th to 13 th day of the experiment) were administered drugs as follows:(a) n 1 : vehicle at the dose of 10 ml/kg/day; (b) n 2 : Met at the dose of 2.5 mg/kg/day; (c) n 3 : ACPA at the dose of 1.0 mg/kg/day. Locomotor behaviour in the Open field test was measured (a) after administration of vehicle on the 1 st experimental day, (b) after the 1 st dose of drugs given on the 7 th day, and (c) on the 14 th day after the "challenge doses" administered in the following manner: n 1 : saline at a dose of 10 ml/kg, n 2, 3 : Met at a dose of 2.5 mg/kg. The observed behavioural changes consisted in: (a) gradual development of habituation to the open field conditions in three consecutive tests; (b) development of behavioural sensitisation to the stimulatory effects of Met after repeated treatment; (c) insignificant effect of repeated pre-treatment with ACPA on the stimulatory effects of Met challenge dose. The results of our study give rise to the question which of the cannabinoid receptor mechanisms might be most responsible for the neuroplastic changes inducing sensitisation to the stimulatory effects of Met. Keywords

show abstract

Section: Discussionmentioning

confidence: 97%

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Landa¹,

Šlais²,

Máchalová³

et al. 2014

Vet. Med. - Czech

View full text Add to dashboard Cite

show abstract

“…A 4-day amphetamine exposure regimen was chosen primarily because of the time constraints of assessing behavior during the adolescent period in rodents (Spear, 2000). Because the goal of this experiment was to examine ST and GT behavior during early/mid-adolescence using an 8-day autoshaping procedure (Flagel et al, 2009; 2008; 2007), 4 days of amphetamine injections were the maximum number of exposures available to induce sensitization prior to ST/GT assessments after a short drug-free period; others also have reported significant expression of behavioral sensitization following only a few repeated stimulant injections (Mathews & McCormick, 2007; Rasmussen, Unterwald, Kim, & Rawls, 2010), or even with as little as one psychostimulant exposure (Vanderschuren et al, 1999).…”

Section: Methodsmentioning

confidence: 99%

Amphetamine-induced incentive sensitization of sign-tracking behavior in adolescent and adult female rats.

Doremus-Fitzwater

Spear

2011

Behavioral Neuroscience

View full text Add to dashboard Cite

Age-specific behavioral and neural characteristics may predispose adolescents to initiate and escalate use of alcohol and drugs. Adolescents may avidly seek novel experiences, including drugs of abuse, because of enhanced incentive motivation for drugs and natural rewards, perhaps especially when that incentive motivation is sensitized by prior drug exposure. Using a Pavlovian conditioned approach (PCA) procedure, sign-tracking (ST) and goal-tracking (GT) behavior was examined in amphetamine-sensitized and control adolescent and adult female Sprague-Dawley rats, with expression of elevated ST behavior used to index enhanced incentive motivation for reward-associated cues. Rats were first exposed to a sensitizing regimen of amphetamine injections (3.0 mg/kg/ml d-amphetamine per day) or given saline (0.9% w/v) once daily for 4 days. Expression of ST and GT was then examined over 8 days of PCA training consisting of 25 pairings of an 8-sec presentation of an illuminated lever immediately followed by responseindependent delivery of a banana-flavored food pellet. Results showed that adults clearly displayed more ST behavior than adolescents, reflected via both more contacts with, and shorter latencies to approach, the lever. Prior amphetamine sensitization increased ST (but not GT) behaviors regardless of age. Thus, when indexed via ST, incentive motivation was found to be greater in adults than adolescents, with a prior history of amphetamine exposure generally sensitizing incentive motivation for cues predicting a food reward regardless of age. Keywords adolescent; amphetamine; sign-tracking; incentive sensitization; rats Adolescents differ from individuals at other ages in the way they respond to and interact with natural rewards and drugs, exhibiting age-related increases in social behavior, noveltyseeking/risk-taking and consummatory behaviors. It is also during adolescence that most drug users have their first drug-related experiences, with almost 50% of high school seniors reporting use of an illicit drug during their lifetime (Johnston, O'Malley, Bachman, & Schulenberg, 2010). Given ethical constraints regarding research that can be conducted with human youth, animal models provide an important tool for researchers to investigate factors

show abstract

“…Dietz et al, 2008; Fiorino and Phillips, 1999; McCormick and Ibrahim, 2007; Rasmussen et al, 2010). There are a number of possibilities as to why adult females in the present study did not respond to initial injection of 1.5 mg/kg amphetamine with enhanced locomotion when indexed via crosses from one side of the apparatus.…”

Section: Discussionmentioning

confidence: 99%

Age-related differences in amphetamine sensitization: Effects of prior drug or stress history on stimulant sensitization in juvenile and adult rats

Doremus-Fitzwater

Spear

2010

Pharmacology Biochemistry and Behavior

View full text Add to dashboard Cite

Repeated intermittent exposure to stimulants progressively increases a drug's effect, with stressors capable of producing cross-sensitization to stimulants. Studies examining such sensitization during development are few, however, with results mixed. In Experiment 1, juvenile (P22) and adult (P64) female Sprague-Dawley rats were administered (daily for 4 days) 1.5 mg/kg or 3.0 mg/kg amphetamine (1.5A and 3.0A groups), or saline (SAL group). In a second experiment, rats were exposed to either repeated restraint (60 min/day for 4 days; RS group) or were left non-manipulated in the home cage (NM group). Animals from both experiments were then challenged with 1.5 mg/ kg of amphetamine and sensitization assessed via locomotion and stereotypy after a 2-day and 3-wk washout period. When compared to SAL animals, 3.0A juveniles and adults exhibited evidence of locomotor sensitization 2 days post-drug exposure, but this sensitization did not persist to the 3-week challenge. Compared to NM animals, RS animals showed stress-induced locomotor sensitization both 2 days and 3 weeks post-stress exposure, regardless of age. These results demonstrate that repeated drug/stress exposures prior to stimulant challenge are sufficient to induce behavioral sensitization among both juveniles and adults, with these effects particularly long-lasting following repeated stressor exposure. Keywordsjuvenile; adult; rat; restraint; amphetamine; behavioral sensitization; locomotor sensitization; stereotypy Behavioral sensitization is defined as a progressive increase in the behavioral response to a drug following repeated administration (for review, see Robinson and Becker, 1986;Robinson and Berridge, 1993), and is evident following exposure to stimulants such as amphetamine (Battisti et al., 1999;Robinson et al., 1998; for review see Robinson and Becker, 1986) and cocaine (Erb and Brown, 2006;Frantz et al., 2007;Laviola et al., 1995), as well as other drugs such as ethanol (Cunningham and Noble, 1992;Masur and Boerngen, 1980;Masur et al., 1986) and nicotine (Benwell and Balfour, 1992;Kita et al., 1992). Sensitization has been argued to be an important contributor to the development of drug addiction (Robinson and Berridge, Address Correspondence to: Dr. Linda Spear, Department of Psychology, Binghamton University PO Box 6000, State University of New York, Binghamton, NY 13902-6000, lspear@binghamton.edu, Phone: 607-777-2825, Fax: 607-777-6418. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. 1993). Locomotor sensitization in particular has been associated with alterations in neural reward substra...

show abstract

Methanandamide blocks amphetamine-induced behavioral sensitization in rats

Cited by 4 publications

References 54 publications

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

The effect of the cannabinoid CB1 receptor agonist arachidonylcyclopropylamide (ACPA) on behavioural sensitisation to methamphetamine in mice

Amphetamine-induced incentive sensitization of sign-tracking behavior in adolescent and adult female rats.

Age-related differences in amphetamine sensitization: Effects of prior drug or stress history on stimulant sensitization in juvenile and adult rats

Contact Info

Product

Resources

About