Methamphetamine Use During Pregnancy

Good, Meadow M.; Solt, Ido; Acuna, J. G.; Rotmensch, Siegfried; Kim, Matthew

doi:10.1097/aog.0b013e3181e67094

Cited by 59 publications

(23 citation statements)

References 26 publications

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“…This observation is in contrast to the human (Good et al, 2010; Smith et al, 2006) and rodent literature (Acuff-Smith et al, 1996, Cho et al, 1991, McDonnell-Dowling et al, 2014, 2015b, 2016) showing that METH use/administration during pregnancy can lead to inadequate weight gain seen in the present study. Multiple reasons could account for the similarities in weight gain.…”

Section: Discussioncontrasting

confidence: 99%

“…While the METH exposure in utero likely plays an important role in affected development, the postnatal environment may be as important to the developing child since a negative postnatal environment characterized by as abuse or neglect has been linked to the development of psychiatric disorders in adulthood (Heim et al, 2004). This is relevant given that METH-taking mothers are more likely to have ongoing legal difficulties, experience domestic violence and experience parenthood as stressful and, thus, are more prone to inferior caregiving (Derauf et al, 2007; Good et al, 2010; Liles et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

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Detrimental effects of self-administered methamphetamine during pregnancy on offspring development in the rat

Rüedi‐Bettschen

Platt

2017

Drug and Alcohol Dependence

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Background Methamphetamine (METH) abuse by pregnant women is a commonly observed phenomenon. While the harmful effects of METH are well described for adults, there is only limited knowledge of the effects of METH use during pregnancy on the developing child. In the present study, we investigated how intraveneous (iv) METH self-administration throughout pregnancy affected rat dams and their offspring through weaning, compared to controls. Methods Female rats (n=16) were trained to self-administer METH iv; every drug infusion by a dam also resulted in a saline injection to a yoked control (n=16). When stable levels of self-administration were reached, all females were mated. Daily, 2-hr self-administration sessions continued until litters were born. General health and weight was assessed daily in dams and pups. In addition, pups were evaluated for achievement of age-appropriate developmental milestones (i.e., righting reflex, negative geotaxis, pinna detachment, fur appearance, incisor eruption and eye opening). Results Dams self-administered 2–3 mg/kg/day METH throughout gestation without consequence to dam health or weight gain during pregnancy. All females produced viable litters, and litter size and composition did not differ between saline and METH dams. Similarly, maternal pup-directed behavior was not affected by prior METH self-administration. However, despite a lack of weight difference in pups, METH-exposed pups were significantly delayed in reaching all assessed developmental milestones compared to controls. Conclusion These results indicate that in utero exposure to moderate METH doses can profoundly and adversely affect offspring development, suggesting that even recreational METH use during pregnancy has potential for harm.

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Detrimental effects of self-administered methamphetamine during pregnancy on offspring development in the rat

Rüedi‐Bettschen

Platt

2017

Drug and Alcohol Dependence

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“…The demographic characteristics of the current sample of maternal methamphetamine users during pregnancy was quite similar to those observed by Good, Solt, Acuna, Rotmensch, and Kim (2010) in an independent medical chart review study of maternal users with respect to maternal race, educational level, socioeconomic status, and polydrug use pre- and postnatally. Similar correspondences were observed between the current sample and pregnant methamphetamine users in federal drug treatment centers (Terplan et al, 2009).…”

Section: Discussionsupporting

confidence: 63%

Examining the relationships between prenatal methamphetamine exposure, early adversity, and child neurobehavioral disinhibition.

Abar¹,

LaGasse²,

Derauf³

et al. 2013

Psychology of Addictive Behaviors

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Methamphetamine use is a growing problem among pregnant women in the United States. Many negative consequences of methamphetamine use have been documented for the users, but little research has examined the long-term association between prenatal methamphetamine exposure (PME) and childhood outcomes. The current study examined the extent to which PME was predictive of childhood neurobehavioral disinhibition (ND), as well as the extent to which early adversity mediated this relationship. A sample of 320 mother–infant dyads (162 PME) was followed from birth through 6.5 years of age. ND was conceptualized as a two factor model consisting of deficits in (a) behavioral and emotional control, and (b) executive function. PME was associated with behavioral and emotional control at 5 years, which was associated with executive function deficits at 6.5 years. Early adversity (birth through year 3) significantly mediated the relationship between PME and ND. Associations with previous research and implications for prevention are discussed.

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“…It is has a high bioavailability and produces profound euphoria with a half-life of 9-15 h [ 8 ] . MDMA (3,4 methylenedeoxymethamphetamine), also known as ecstasy, is an analog of methamphetamine that shares properties with amphetamine and hallucinogenics [ 54 ] . Adderall, a combination of amphetamine and dextroamphetamine, is also a part of the amphetamine family that is frequently used by women of reproductive age for treatment of attention defi cit/hyperactivity disorder.…”

Section: Amphetaminesmentioning

confidence: 99%

Drugs, Alcohol, and Pregnant Women: Anesthetic Implications for Mother and Newborn

Saloum

Epstein

2011

Perioperative Addiction

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Methamphetamine Use During Pregnancy

Abstract: II.

Cited by 59 publications

References 26 publications

Detrimental effects of self-administered methamphetamine during pregnancy on offspring development in the rat

Detrimental effects of self-administered methamphetamine during pregnancy on offspring development in the rat

Examining the relationships between prenatal methamphetamine exposure, early adversity, and child neurobehavioral disinhibition.

Drugs, Alcohol, and Pregnant Women: Anesthetic Implications for Mother and Newborn

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