Methamphetamine-lnduced Behavioral Alterations Following Repeated Administration of Methamphetamine

Yamanaka, Yasumitsu; Takano, Ritsuko; Egashira, Toru

doi:10.1254/jjp.41.147

Cited by 5 publications

(2 citation statements)

References 17 publications

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“…The challenge injection of (+)-amphetamine produced a similar increase in the extracellular concentration of DA in methamphetamine-and saline-pretreated rats, but a much larger initial behavioral response in the methamphetamine-pretreated animals. It is not clear what is responsible for the behavioral effect, but it seems to be a reliable phenomenon because it has been also reported in mice given neurotoxic doses of methamphetamine [16]. Striatal DA receptor supersensitivity could be involved, but this does not develop until striatal DA is depleted by over 80-85% [15].…”

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confidence: 99%

The long-term effects of neurotoxic doses of methamphetamine on the extracellular concentration of dopamine measured with microdialysis in striatum

Robinson

Yew

Paulson

et al. 1990

Neuroscience Letters

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The extracellular concentrations of dopamine (DA), dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA) in the striatum were measured by in vivo microdialysis in freely moving rats one week after the animals were treated with neurotoxic doses of methamphetamine. Methamphetamine produced a marked depletion of striatal DA measured in postmortem tissue, and in the extracellular concentrations of DOPAC, HVA and 5-HIAA. In contrast, the resting extracellular concentration of DA in striatum was the same as in saline-pretreated controls. Furthermore, methamphetamine-pretreated rats were able to increase their concentration of extracellular DA to the same extent as controls in response to a (+)-amphetamine challenge. It is suggested that this adaptive response is probably responsible, at least in part, for the absence of obvious behavioral deficits in animals exposed to neurotoxic doses of methamphetamine.

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confidence: 99%

The long-term effects of neurotoxic doses of methamphetamine on the extracellular concentration of dopamine measured with microdialysis in striatum

Robinson

Yew

Paulson

et al. 1990

Neuroscience Letters

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show abstract

“…in a volume of 10 mL/kg body weight. All experiments were conducted with the METH dose at 4 mg/kg that reportedly induces not abnormal behaviors, 14 but place preference in wild‐type mice. Methamphetamine was freshly prepared for all of the experiments.…”

Section: Methodsmentioning

confidence: 99%