Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ

Luo, Baozhen; Zhou, Jie; Guo, Dan; Yang, Qian; Cai, Dunpeng; Zhou, Rui-Mei; Xu, Zhenzhen; Wang, Huijun; Chen, Shiyou; Xie, Wei‐Bing

doi:10.1016/j.bbadis.2022.166447

Cited by 10 publications

(7 citation statements)

References 46 publications

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“…BAPN is the most commonly used chemical to induce TAAs in rodents [25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43]. BAPN is an inhibitor of lysyl oxidase, and the latter mediates the crosslinking process of elastin and collagen.…”

Section: β-Aminopropionitrile (Bapn)-induced Taa In Rodentsmentioning

confidence: 99%

“…Moreover, the induction time can be shortened to 1 or 2 weeks to observe early changes in TAA initiation [37] or it can be extended up to 26 weeks to observe late changes in disease progression including TAA rupture and mortality [41]. It is worth noting that rats are also used in this model [43] (Table 1).…”

Section: β-Aminopropionitrile (Bapn)-induced Taa In Rodentsmentioning

confidence: 99%

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Animal Models, Pathogenesis, and Potential Treatment of Thoracic Aortic Aneurysm

Wang,

Panicker,

Anesi

et al. 2024

IJMS

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Thoracic aortic aneurysm (TAA) has a prevalence of 0.16–0.34% and an incidence of 7.6 per 100,000 person-years, accounting for 1–2% of all deaths in Western countries. Currently, no effective pharmacological therapies have been identified to slow TAA development and prevent TAA rupture. Large TAAs are treated with open surgical repair and less invasive thoracic endovascular aortic repair, both of which have high perioperative mortality risk. Therefore, there is an urgent medical need to identify the cellular and molecular mechanisms underlying TAA development and rupture to develop new therapies. In this review, we summarize animal TAA models including recent developments in porcine and zebrafish models: porcine models can assess new therapeutic devices or intervention strategies in a large mammal and zebrafish models can employ large-scale small-molecule suppressor screening in microwells. The second part of the review covers current views of TAA pathogenesis, derived from recent studies using these animal models, with a focus on the roles of the transforming growth factor-beta (TGFβ) pathway and the vascular smooth muscle cell (VSMC)-elastin-contractile unit. The last part discusses TAA treatment options as they emerge from recent preclinical studies.

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Section: β-Aminopropionitrile (Bapn)-induced Taa In Rodentsmentioning

confidence: 99%

Section: β-Aminopropionitrile (Bapn)-induced Taa In Rodentsmentioning

confidence: 99%

Animal Models, Pathogenesis, and Potential Treatment of Thoracic Aortic Aneurysm

Wang,

Panicker,

Anesi

et al. 2024

IJMS

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show abstract

“…BAPN is the most commonly used chemical to induce TAAs in rodents [21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39]. BAPN is an inhibitor of lysyl oxidase, and the latter mediates the crosslinking process of elastin and collagen.…”

Section: β-Aminopropionitrile (Bapn)-induced Taa In Rodentsmentioning

confidence: 99%

Animal Models and Pathogenesis of Thoracic Aortic Aneurysm

Wang,

Panicker,

Anesi

et al. 2023

Preprint

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Thoracic aortic aneurysm (TAA) has a prevalence of 0.16%-0.34% and an incidence of 7.6 per 100,000 person-years, accounting for 1%-2% of all deaths in Western countries. Currently, no effective pharmacological therapies have been identified to slow TAA development and prevent TAA rupture. Large TAAs are treated with open surgical repair and less invasive thoracic endovascular aortic repair, both of which have high perioperative mortality risk. Therefore, there is an urgent medical need to identify the cellular and molecular mechanisms underlying TAA development and rupture to develop new therapies. In this review, we summarize animal TAA models including recent developments in porcine and zebrafish models: porcine models can assess new therapeutic devices or intervention strategies in a large mammal and zebrafish models can employ large-scale small-molecule suppressor screening in microwells. The second part of the review covers current views of TAA pathogenesis, with a focus on the roles of the transforming growth factor-beta (TGFβ) pathway and the vascular smooth muscle cell (VSMC)-elastin-contractile unit. The last part discusses TAA treatment options as they emerge from recent preclinical studies.

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“…Animal models of AD should prove useful to understand the mechanism underlying the occurrence of this condition. Previously, AD rat models were generated via the administration of β-aminopropionitrile (BAPN) [18][19][20], an irreversible and orally active lysyl-oxidase inhibitor, for 6-7 weeks [21,22]. The modulation of the period of administration of BAPN enabled us to prepare models at various stages of AD.…”

Section: Introductionmentioning

confidence: 99%

Delamination Strength and Elastin Interlaminar Fibers Decrease with the Development of Aortic Dissection in Model Rats

Kurihara,

Ujihara,

Nakamura

et al. 2023

Bioengineering

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Aortic dissection (AD) is a life-threatening tear of the vascular tissue with creation of a false lumen. To explore the mechanism underlying this tissue tear, this study investigated the delamination strength of AD model rats and the histological composition of the aorta at various stages of AD development. SD rats were administrated beta-amino propionitrile for 0 (Control), 3 (Pre-dissection), and 6 (Dissection) weeks. The thoracic aorta was harvested at 10–11 weeks of age. The Dissection group exclusively showed AD at the ascending aorta. The delamination strength, a force that separates the aorta in the radial direction, of the descending aorta decreased significantly in the order of the Control, Pre-dissection, and Dissection groups. A quantitative histological analysis of the aortic tissue demonstrated that, compared with the Control group, the area fraction of collagen was significantly higher in the Pre-dissection and Dissection groups and that of elastin was significantly lower in the Dissection group. The area fraction of the elastin fibers between the elastic laminas (interlaminar fibers) was significantly decreased in the order of the Control, Pre-dissection, and Dissection groups. Histological changes of the aortic tissue, perhaps a reduction in interlaminar fibers mainly aligned in the radial direction, decreased delamination strength, thereby causing AD.

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Methamphetamine induces thoracic aortic aneurysm/dissection through C/EBPβ

Cited by 10 publications

References 46 publications

Animal Models, Pathogenesis, and Potential Treatment of Thoracic Aortic Aneurysm

Animal Models, Pathogenesis, and Potential Treatment of Thoracic Aortic Aneurysm

Animal Models and Pathogenesis of Thoracic Aortic Aneurysm

Delamination Strength and Elastin Interlaminar Fibers Decrease with the Development of Aortic Dissection in Model Rats

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