Methamphetamine-induced reduction in D1 and D2 dopamine receptors as evidenced by autoradiography: Comparison with tyrosine hydroxylase activity

McCabe, R. Tyler; Hanson, Glen R.; Dawson, Ted M.; Wamsley, James K.; Gibb, James W.

doi:10.1016/0306-4522(87)90287-9

Cited by 36 publications

(21 citation statements)

References 26 publications

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“…In the NAcc, there is a decrease in the number of D 1 and D 2 receptors 1 day after the administration of neurotoxic doses of methamphetamine, but receptor levels return to normal 7 days after administration (McCabe et al 1987;Ujike et al 1991). Based on these latter studies, it appears unlikely that receptors in the NAcc were upregulated during conditioning in the current study.…”

Section: Discussionmentioning

confidence: 96%

“…Interestingly, research has shown that D 1 dopamine receptors are upregulated in the lateral part of the substantia nigra for up to 21 days after administration of a neurotoxic regimen of methamphetamine (Ujike et al 1991). There is also evidence that D 2 dopamine receptors in the Str are upregulated at 7 days, but return to normal by 21 days, after treatment with neurotoxic doses of methamphetamine (McCabe et al 1987).…”

Section: Discussionmentioning

confidence: 96%

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The effect of neurotoxic doses of methamphetamine on methamphetamine-conditioned place preference in rats

et al. 2003

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 96%

The effect of neurotoxic doses of methamphetamine on methamphetamine-conditioned place preference in rats

et al. 2003

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“…1 and 3b). Repeated administration of meth decreases dopamine D 1 and D 2 receptors and probably the NE α-2 autoreceptors that may be involved in this hypolocomotion [48]. …”

Section: Discussionmentioning

confidence: 99%

Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: Low doses induce hypolocomotion

Singh

Kosten

Kinsey

et al. 2012

Pharmacology Biochemistry and Behavior

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The overall goal of the present study was to determine the effects of different doses of (+)-methamphetamine (meth) on locomotor activity of Balb/C mice. Four experiments were designed to test a wide range of meth doses in BALB/c female mice. In Experiment 1, we examined locomotor activity induced by an acute administration of low doses of meth (0.01 and 0.03 mg/kg) in a 90-min session. Experiment 2 was conducted to test higher meth doses (0.3 – 10 mg/kg). In Experiment 3, separate sets of mice were pre-treated with various meth doses once or twice (one injection/week) prior to a locomotor challenge with a low meth dose. Finally, in Experiment 4, we tested whether locomotor activation would be affected by pretreatment with a low or moderate dose of meth one month prior to the low meth dose challenge. Results show that low doses of meth induce hypolocomotion whereas moderate to high doses induce hyperlocomotion. Prior exposure to either one moderate or high dose of meth or to two, low doses of meth attenuated the hypolocomotor effect of a low meth dose one week later. This effect was also attenuated in mice tested one month after administration of a moderate meth dose. These results show that low and high doses of meth can have opposing effects on locomotor activity. Further, prior exposure to the drug leads to tolerance, rather than sensitization, of the hypolocomotor response to low meth doses.

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“…For example, MA abuse in humans is associated with striatal DA D 1 receptors upregulation and striatal DA D 2 receptor downregulation (Volkow et al, 2001a, Volkow et al, 2001b, Volkow et al, 2001c, Worsley et al, 2000). Animal studies show somewhat different effects following MA administration in that MA produces reductions in both DA D 1 and D 2 receptor expression with seemingly greater reductions in DA D 1 receptors following repeated experimenter-delivered MA (McCabe et al, 1987, Segal et al, 2005, Stefanski et al, 1999). More recent data suggests that DA receptor downregulation is offset by increases in high affinity DA D 1 and D 2 receptors following chronic MA treatment (Shuto et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Role of adenosine receptor subtypes in methamphetamine reward and reinforcement

et al. 2015

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The neurobiology of methamphetamine (MA) remains largely unknown despite its high abuse liability. The present series of studies explored the role of adenosine receptors on MA reward and reinforcement and identified alterations in the expression of adenosine receptors in dopamine terminal areas following MA administration in rats. We tested whether stimulating A1 or A2A adenosine receptor subtypes would influence MA-induced place preference or MA self-administration on fixed and progressive ratio schedules in male Sprague-Dawley rats. Stimulation of either adenosine A1 or A2A receptors significantly reduced the development of MA-induced place preference. Stimulating A1, but not A2A, adenosine receptors reduced MA self-administration responding. We next tested whether repeated experimenter-delivered MA administration would alter the expression of adenosine receptors in the striatal areas using immunoblotting. We observed no change in the expression of adenosine receptors. Lastly, rats were trained to self-administer MA or saline for 14 days and we detected changes in adenosine A1 and A2A receptor expression using immunoblotting. MA self-administration significantly increased adenosine A1 in the nucleus accumbens shell, caudate-putamen and prefrontal cortex. MA self-administration significantly decreased adenosine A2A receptor expression in the nucleus accumbens shell, but increased A2A receptor expression in the amygdala. These findings demonstrate that MA self-administration produces selective alterations in adenosine receptor expression in the nucleus accumbens shell and that stimulation of adenosine receptors reduces several behavioral indices of MA addiction. Together, these studies shed light onto the neurobiological alterations incurred through chronic MA use that may aid in the development of treatments for MA addiction.

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Methamphetamine-induced reduction in D1 and D2 dopamine receptors as evidenced by autoradiography: Comparison with tyrosine hydroxylase activity

Cited by 36 publications

References 26 publications

The effect of neurotoxic doses of methamphetamine on methamphetamine-conditioned place preference in rats

The effect of neurotoxic doses of methamphetamine on methamphetamine-conditioned place preference in rats

Dose-dependent changes in the locomotor responses to methamphetamine in BALB/c mice: Low doses induce hypolocomotion

Role of adenosine receptor subtypes in methamphetamine reward and reinforcement

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