Methamphetamine-induced lethal toxicity in zebrafish larvae

Chen, Yu; Wisner, Alexander; Schiefer, Isaac T.; Williams, Frederick; Hall, F. Scott

doi:10.1007/s00213-022-06252-z

Cited by 2 publications

(2 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An increase in dopamine and norepinephrine (but with lower variability) and a decrease in serotonin was also observed in the brains of rosy bitterling Rhodeus ocellatus (Kner, 1866), loach Paramisgurnus dabryanus (Dabry de Thiersan 1872), and mosquito fish Gambusia affinis (Baird & Girard, 1853), and particularly intense in Chinese medaka Oryzias sinensis Chen, Uwa & Chu, 1989 fish (up to 2.5-fold) after 20 days of waterborne METH exposure (25 µg/L) [ 89 ]. It should be noted that METH-induced lethality in zebrafish larvae in a dose-dependent manner in the range of concentration from 500 μM to 50 mM for 5 h, which was linked to initial sympathomimetic activation mediated by the dopaminergic system [ 119 ]. Despite being less sensitive to the effects of METH compared to serotonergic systems, the dopaminergic system’s activation could potentially have detrimental effects on the health status of fish and even lead to biodiversity decline.…”

Section: Bioaccumulation Of Illicit Drugs and Their Toxicitymentioning

confidence: 99%

Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook

Falfushynska,

Rychter,

Boshtova

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

The United Nations World Drug Report published in 2022 alarmed that the global market of illicit drugs is steadily expanding in space and scale. Substances of abuse are usually perceived in the light of threats to human health and public security, while the environmental aspects of their use and subsequent emissions usually remain less explored. However, as with other human activities, drug production, trade, and consumption of drugs may leave their environmental mark. Therefore, this paper aims to review the occurrence of illicit drugs in surface waters and their bioaccumulation and toxicity in fish. Illicit drugs of different groups, i.e., psychostimulants (methamphetamines/amphetamines, cocaine, and its metabolite benzoylecgonine) and depressants (opioids: morphine, heroin, methadone, fentanyl), can reach the aquatic environment through wastewater discharge as they are often not entirely removed during wastewater treatment processes, resulting in their subsequent circulation in nanomolar concentrations, potentially affecting aquatic biota, including fish. Exposure to such xenobiotics can induce oxidative stress and dysfunction to mitochondrial and lysosomal function, distort locomotion activity by regulating the dopaminergic and glutamatergic systems, increase the predation risk, instigate neurological disorders, disbalance neurotransmission, and produce histopathological alterations in the brain and liver tissues, similar to those described in mammals. Hence, this drugs-related multidimensional harm to fish should be thoroughly investigated in line with environmental protection policies before it is too late. At the same time, selected fish species (e.g., Danio rerio, zebrafish) can be employed as models to study toxic and binge-like effects of psychoactive, illicit compounds.

show abstract

Section: Bioaccumulation Of Illicit Drugs and Their Toxicitymentioning

confidence: 99%

Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook

Falfushynska,

Rychter,

Boshtova

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…As emerging organic pollutants, illicit drugs are of great concern due to their ubiquity, teratogenic potency, and neurotoxicity [ 22 , 34 ]. Methamphetamine (METH) is the primary illicit drug widely detected in the surface water of China, with the highest concentrations up to 405 ng L −1 [ 35 ].…”

Section: Introductionmentioning

confidence: 99%

Methamphetamine Shows Different Joint Toxicity for Different Types of Microplastics on Zebrafish Larvae by Mediating Oxidative Stress

Xu,

Yang,

Wang

et al. 2023

Toxics

View full text Add to dashboard Cite

The coexistence of polystyrene (PS) and polypropylene (PVC) microplastics (MPs) and methamphetamine (METH) in aquatic systems is evident. However, the joint toxicity is unclear. Here, zebrafish larvae were exposed to single PS and PVC MPs (20 mg L−1) and combined with METH (250 and 500 μg L−1) for 10 days. The results indicated that acute exposure to PS and PVC MPs induced lethal effects on zebrafish larvae (10–20%). Treatment with MPs markedly suppressed the locomotion of zebrafish, showing as the lengthy immobility (51–74%) and lower velocity (0.09–0.55 cm s−1) compared with the control (1.07 cm s−1). Meanwhile, histopathological analysis revealed pronounced depositions of MPs particles in fish’s intestinal tract, triggering inflammatory responses (histological scores: 1.6–2.0). In the coexposure groups, obviously inflammatory responses were found. Furthermore, the up-regulations of the genes involved in the oxidative kinase gene and inflammation related genes implied that oxidative stress triggered by MPs on zebrafish larvae might be responsible for the mortality and locomotion retardant. The antagonistic and stimulatory effects of METH on the expression changes of genes found in PVC and PS groups implied the contrary combined toxicity of PS/PVC MPs and METH. This study for the first time estimated the different toxicity of PS and PVC MPs on fish and the joint effects with METH at high environmental levels. The results suggested PS showed stronger toxicity than PVC for fish larvae. The addition of METH stimulated the effects of PS but antagonized the effects of PVC, promoting control strategy development on MPs and METH in aquatic environments.

show abstract

Methamphetamine-induced lethal toxicity in zebrafish larvae

Cited by 2 publications

References 69 publications

Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook

Illicit Drugs in Surface Waters: How to Get Fish off the Addictive Hook

Methamphetamine Shows Different Joint Toxicity for Different Types of Microplastics on Zebrafish Larvae by Mediating Oxidative Stress

Contact Info

Product

Resources

About