Methamphetamine exposure from postnatal day 11 to 20 causes impairments in both behavioral strategies and spatial learning in adult rats

Williams, Michael T.; Boon, Francis; Saber, Andrea J; Cain, Donald P.

doi:10.1016/s0006-8993(02)03620-x

Cited by 49 publications

(64 citation statements)

References 43 publications

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“…We have previously shown that MA exposure from P11-20 causes deficits in MWM learning and memory (Vorhees et al, 1994a(Vorhees et al, , b, 1996(Vorhees et al, , 1999Williams et al, 2002Williams et al, , 2003a. Consistent with these findings, we showed that MA exposure caused learning deficits when the animals were tested here.…”

Section: Discussionsupporting

confidence: 90%

“…Previous studies have shown that MA causes deficits in reference memory on probe trials in the MWM Williams et al, 2002Williams et al, , 2003b, and that MA does not induce sensorimotor deficits in animals exposed neonatally Williams et al, 2002Williams et al, , 2003b.…”

Section: Straight Channel-onmentioning

confidence: 86%

“…In rats, exposure to MA from postnatal days (P)11-20 causes long-term spatial learning and memory deficits (Vorhees et al, 1994a(Vorhees et al, , b, 2000Williams et al, 2002Williams et al, , 2003a. This period is approximately analogous to mid-second through third trimester human hippocampal development (Bayer et al, 1993).…”

Section: Introductionmentioning

confidence: 99%

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Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits

Skelton

Williams

Schaefer

2007

Psychoneuroendocrinology

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SummaryIn this study, brain derived neurotrophic factor (BDNF) and nerve growth factor (NGF) were examined at five time points [postnatal day (P)11, 15, 20, 21, and 68 (the latter with or without behavioral testing)] during and after P11-20 (+)-methamphetamine (MA) (10 mg/ kg 4 × day) treatment. BDNF in MA-treated animals was elevated on P15 and P20 in the hippocampus but not in the hypothalamus and was unchanged on P11 and P21. On P68 (1 h after Morris water maze testing) MA-treated offspring showed a trend toward higher levels of BDNF in the hippocampus than saline-treated animals. MA treatment increased NGF levels in the hippocampus but only on P20. No effect of MA treatment was observed in the elevated zero maze. MA-treated offspring had increased latencies, cumulative distances, path lengths, and first bearings in the Morris water maze. The findings indicate that early MA exposure induces hippocampal BDNF increases that precede the later emergence of spatial learning deficits.

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Section: Discussionsupporting

confidence: 90%

Section: Straight Channel-onmentioning

confidence: 86%

See 1 more Smart Citation

Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits

Skelton

Williams

Schaefer

2007

Psychoneuroendocrinology

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“…The task cannot be solved using spatial navigation because of the randomized start-goal combinations but it teaches the subject the basic task requirements -namely, the escape can only be found by searching, the goal is located somewhere away from the wall and the platform is the goal. Cain [34][35][36][37][38][39] , Morris 15 and Whishaw 40 have demonstrated that 'non-spatial' pretraining can separate components of learning that are not spatial from those that are and this, in turn, can change the interpretation of the findings. As non-spatial or strategy pretraining and cued training both have the effect of teaching animals the basic task requirements and tend to eliminate behaviors such as swimovers, jump-offs and even diving, it can be helpful to conduct cued trials first.…”

Section: Control Proceduresmentioning

confidence: 99%

Morris water maze: procedures for assessing spatial and related forms of learning and memory

2006

Self Cite

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The Morris water maze (MWM) is a test of spatial learning for rodents that relies on distal cues to navigate from start locations around the perimeter of an open swimming arena to locate a submerged escape platform. Spatial learning is assessed across repeated trials and reference memory is determined by preference for the platform area when the platform is absent. Reversal and shift trials enhance the detection of spatial impairments. Trial-dependent, latent and discrimination learning can be assessed using modifications of the basic protocol. Search-to-platform area determines the degree of reliance on spatial versus non-spatial strategies. Cued trials determine whether performance factors that are unrelated to place learning are present. Escape from water is relatively immune from activity or body mass differences, making it ideal for many experimental models. The MWM has proven to be a robust and reliable test that is strongly correlated with hippocampal synaptic plasticity and NMDA receptor function. We present protocols for performing variants of the MWM test, from which results can be obtained from individual animals in as few as 6 days.

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“…Subject groups were composed of randomly selected same-sex littermates, with a maximum of two pups used from any given litter to reduce the probability that litter effects influenced the experimental results [20,46,79]. Subjects were housed in standard shoebox cages with wood chip bedding (Beta Chip, Northeastern Products, Warrensburg, NY) and maintained under a 12-hour (h) light-dark cycle (lights on at 0700 h) and a stable, environmental temperature of 22 °C with ad libitum access to food (Formulab Diet 5008, PMI, Nutrition International, Brentwood, MO) and water.…”

Section: Subjectsmentioning

confidence: 99%

Behavioral responses during the initial exposures to a low dose of cocaine in late preweanling and adult rats

Smith

Morrell

2008

Neurotoxicology and Teratology

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Human drug experimentation begins during late childhood and early adolescence, a critical time in physical and CNS development, when the immature CNS is vulnerable to the long-term effects of psychoactive drugs. Few preclinical animal studies have investigated responses to such drugs in a developmental stage equivalent to late childhood of humans. We used a rodent model to examine behavioral responses of female Sprague-Dawley late preweanling and adult rats during acute and repeated exposures to a low dose of cocaine. Results show that after cocaine injection, preweanling rats (18-21 days old) have locomotor responses that differ from adults, but after postnatal day 22, the responses are indistinguishable from adults even though rats are still not weaned. Before day 22, locomotor effects of cocaine differ from those in adults in three ways: preweanlings are active for a longer time after cocaine injection at day 18; preweanling activity peaks more rapidly after subcutaneous administration; and after only three injections of cocaine, a tolerance-like pattern is seen in preweanlings whereas an emerging pattern of sensitization to cocaine is seen in adults. The behavioral patterns of this age group offer a preclinical model of the early effects of drugs of abuse.

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Methamphetamine exposure from postnatal day 11 to 20 causes impairments in both behavioral strategies and spatial learning in adult rats

Cited by 49 publications

References 43 publications

Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits

Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits

Morris water maze: procedures for assessing spatial and related forms of learning and memory

Behavioral responses during the initial exposures to a low dose of cocaine in late preweanling and adult rats

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