Methamphetamine and Other Substance Use During Pregnancy: Preliminary Estimates From the Infant Development, Environment, and Lifestyle (IDEAL) Study

Arria, Amelia M.; Derauf, Chris; LaGasse, Linda L.; Grant, Penny; Shah, Rizwan; Smith, Lynne M.; Haning, William; Huestis, Marilyn A.; Strauss, Arthur; Grotta, Sheri Della; Liu, Jing; Lester, Barry M.

doi:10.1007/s10995-005-0052-0

Cited by 191 publications

(111 citation statements)

References 40 publications

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“…The Substance Abuse and Mental Health Services Administration (SAMHSA) reported that among pregnant women age 15-44 years, 4.6% used illicit drugs in the previous month [42]. Consistent with the SAMHSA report, we found approximately 6% of women reported drug use during pregnancy in the multisite Infant Development, Environment and Lifestyle (IDEAL) study [2].…”

Section: Introductionsupporting

confidence: 85%

“…The study was approved by the Institutional Review Boards at all participating sites. Prior to initiation of recruitment, personnel from all sites met for a week-long training session so that procedures could be standardized [2]. Recruitment is planned for two years; we present neonatal neurodevelopmental findings in the cohort recruited by year one.…”

Section: Methodsmentioning

confidence: 99%

“…Matching criteria reduced disparities between groups related to race, social class and poverty, and prematurity. The exposed and unexposed groups enrolled in follow up differed in demographic characteristics from the larger sample [2].…”

Section: Participantsmentioning

confidence: 96%

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Prenatal methamphetamine use and neonatal neurobehavioral outcome

Smith

LaGasse²,

Derauf

et al. 2008

Neurotoxicology and Teratology

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164

127

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Background-Methamphetamine (MA) use among pregnant women is an increasing problem in the United States. How prenatal MA exposure affects neonatal neurobehavior is unknown.Objective-To examine the neurobehavioral effects of prenatal MA exposure.Design-The Infant Development, Environment and Lifestyle (IDEAL) study screened 13,808 subjects and 1632 were eligible and consented. 166 (n=74 exposed) were enrolled in a longitudinal follow up. Exposure was determined by meconium assay and self-report with alcohol, marijuana, and tobacco present in both groups. The NICU Network Neurobehavioral Scale (NNNS) was administered within the first 5 days of life. Analyses conducted on NNNS summary scores included exposure group effects, heavy MA use effects, association with frequency of use by trimester, and dose-response relationships with amphetamine metabolites.Results-After adjusting for covariates, exposure to MA was associated with increased physiological stress. Heavy MA use was related to lower arousal, more lethargy, and increased physiological stress. First trimester MA use was related to elevated physiological stress. Third trimester use was related to poorer quality of movement. Higher level of amphetamine metabolites in meconium was associated with increased CNS stress.Conclusions-Prenatal MA exposure was associated with neurobehavioral patterns of decreased arousal, increased stress, and poor quality of movement. The dose response relationships may represent neurotoxic effects from MA.

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Section: Introductionsupporting

confidence: 85%

Section: Methodsmentioning

confidence: 99%

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Prenatal methamphetamine use and neonatal neurobehavioral outcome

Smith

LaGasse²,

Derauf

et al. 2008

Neurotoxicology and Teratology

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164

127

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“…Tobacco is the most commonly used substance during pregnancy [16]: up to 25% of pregnant women smoke [17,18].Smoking during pregnancy causes additional health problems, including premature birth, certain birth defects, babies born too small, babies who die before they can be born at all. Smoking causes shortage of oxygen which in turn has devastating effects on baby's growth and development.…”

Section: Consequences Of Smoking During Pregnancy:-mentioning

confidence: 99%

Review: Smoking During Pregnancy Menacing to Baby.

Joon¹,

Jalandra²

2017

IJAR

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“…The prevalence of maternal drug use during pregnancy in Canada [1] and the US [2] has been estimated to be as high as 6-10%. The consequences for the newborn are severe, and include increased risk for perinatal mortality and morbidity, as well as ongoing physical, neurobehavioral, and psychosocial problems [3][4][5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Auricular acupuncture for chemically dependent pregnant women: a randomized controlled trial of the NADA protocol

Janssen¹,

Kelly²,

Thiessen³

et al. 2013

Deutsche Zeitschrift für Akupunktur

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Background: The prevalence of maternal drug use during pregnancy in North America has been estimated to be as high as 6-10%. The consequences for the newborn include increased risk for perinatal mortality and ongoing physical, neurobehavioral, and psychosocial problems. Methadone is frequently used to wean women off street drugs but is implicated as a cause of adverse fetal/neonatal outcomes itself. The purpose of our study was to test the ability of maternal acupuncture treatment among mothers who use illicit drugs to reduce the frequency and severity of withdrawal symptoms among their newborns. Methods: We randomly assigned chemically dependent pregnant women at BC Women's Hospital in Vancouver, British Columbia to daily acupuncture treatments versus usual care. By necessity, neither our participants nor acupuncturists were blinded as to treatment allocation. Our primary outcome was days of neonatal morphine treatment for symptoms of neonatal withdrawal. Secondary neonatal outcomes included admission to a neonatal ICU and transfer to foster care. Results: We randomized 50 women to acupuncture and 39 to standard care. When analyzed by randomized groups, we did not find benefit of acupuncture; the average length of treatment with morphine for newborns in the acupuncture group was 2.7 (6.3) compared to 2.8 (7.0) in the control group. Among newborns of women who were compliant with the acupuncture regime, we observed a reduction of 2.1 and 1.5 days in length of treatment for neonatal abstinence syndrome compared to the non-compliant and control groups, respectively. These differences were not statistically significant. Conclusions: Acupuncture may be a safe and feasible treatment to assist mothers to reduce their dosage of methadone. Our results should encourage ongoing studies to test the ability of acupuncture to mitigate the severity of neonatal abstinence syndrome among their newborns. Clinical Trial Registration: http://www.clinicaltrials.gov registry: W05-0041

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Methamphetamine and Other Substance Use During Pregnancy: Preliminary Estimates From the Infant Development, Environment, and Lifestyle (IDEAL) Study

Cited by 191 publications

References 40 publications

Prenatal methamphetamine use and neonatal neurobehavioral outcome

Prenatal methamphetamine use and neonatal neurobehavioral outcome

Review: Smoking During Pregnancy Menacing to Baby.

Auricular acupuncture for chemically dependent pregnant women: a randomized controlled trial of the NADA protocol

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