Methamphetamine- and 3,4-Methylenedioxymethamphetamine–Induced Behavioral Changes in Histamine H3–Receptor Knockout Mice

Okuda, Tomohiro; Zhang, Dongying; Shao, He; Okamura, Nobuyuki; Takino, Naoko; Iwamura, Tatsunori; Sakurai, Eiko; Yoshikawa, Takeo; Yanai, Kazuhiko

doi:10.1254/jphs.09024fp

Cited by 30 publications

(18 citation statements)

References 27 publications

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“…This was detected during the first 3-5 min following alcohol administration in place conditionings (EtOH dose 2 g/kg, two first days) and when a lower dose of alcohol (1.5 g/kg) was used and horizontal activity was recorded for a longer period. In agreement with our finding, H3R KO mice are not stimulated by methamphetamine (Toyota et al, 2002;Okuda et al, 2009). The H3R KO did not differ from B6 control mice in rotarod task but made fewer mistakes as measured by number of foot slips on the balance beam test following alcohol administration.…”

Section: Discussionsupporting

confidence: 93%

Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice

Nuutinen

Lintunen

Vanhanen

et al. 2011

Neuropsychopharmacol

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Recent research suggests that histamine H3 receptor (H3R) antagonism may diminish motivational aspects of alcohol dependence. We studied the role of H3Rs in alcohol-related behaviors using H3R knockout (KO) mice and ligands. H3R KO mice consumed less alcohol than wild-type (WT) mice in a two-bottle free-choice test and in a 'drinking in the dark' model. H3R antagonist ciproxifan suppressed and H3R agonist immepip increased alcohol drinking in C57BL/6J mice. Impairment in reward mechanisms in H3R KO mice was confirmed by the lack of alcohol-evoked conditioned place preference. Plasma alcohol concentrations of H3R KO and WT mice were similar. There were no marked differences in brain biogenic amine levels in H3R KO mice compared with the control animals after alcohol drinking. In conclusion, the findings of this study provide evidence for the role of H3R receptor in alcohol-related behaviors, especially in alcohol drinking and alcohol reward. Thus, targeting H3Rs with a specific antagonist might be a potential means to treat alcoholism in the future.

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Section: Discussionsupporting

confidence: 93%

Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice

Nuutinen

Lintunen

Vanhanen

et al. 2011

Neuropsychopharmacol

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“…We recently reported the heterogeneous properties of histaminergic neurotransmission, in which deficiency in H 3 receptor has an inhibitory effect on psychostimulantsinduced increase in locomotion, but negligible effect on the reward (51). In that study, we compared psychostimulants-induced behavioral changes to the expression of c-Fos protein as an indicator of neuronal activity.…”

Section: Discussionmentioning

confidence: 99%

Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats

Sakurai

Kuramasu

et al. 2010

J Pharmacol Sci

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Abstract. Sleep deprivation induces several negative effects on behavior, emotion, attention, and learning ability. Sleep appears to be particularly important during adolescent brain development. In the present study, we examined the effects of sleep deprivation on behavior and hypothalamic neurotransmission including histamine and orexin neurons in adolescent rats using the treadmill method. Adolescent male rats were divided into three groups: treadmill sleep-deprived, treadmill control, and cage control groups. Energy expenditure, anxiety-like behavior, and locomotor activity were examined among the three groups. Histamine concentration in the cortex and diencephalon and the number of c-Fos-positive neurons in the hypothalamus were also examined. In addition, histamine and orexin neurons in the hypothalamus were simultaneously identified using rat histidine decarboxylase and orexin-A immunohistochemistry, respectively. Both energy expenditure and anxiety-related behavior significantly increased by the experimental 3-day sleep deprivation, while exploratory locomotor activity significantly decreased. Histamine contents did not change in the cortex, but significantly decreased in the diencephalon of sleep-deprived rats. Increased expression of c-Fos-positive neurons, including subgroup histamine and orexin neurons, was observed in the hypothalamus. These findings indicate that sleep deprivation increases energy expenditure and anxiety in adolescent rats and provide evidence for the pivotal role of hypothalamus subgroup histamine and orexin neurons in the behavioral response to sleep deprivation.

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“…-The MDMA-induced increase in locomotion, observed in wt mice, was less pronounced in histamine H3 receptor (H3R) -/-mice, pointing to a functional interaction between histaminergic and serotonergic neurons which modulates the locomotor effects of MDMA [54].…”

Section: Ii2 Hyperlocomotionmentioning

confidence: 92%

Mice in Ecstasy: Advanced Animal Models in the Study of MDMA

Stove¹,

Letter²,

Piette³

et al. 2010

CPB

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The party drug 3,4-methylenedioxymethamphetamine -better known as MDMA or ecstasy-has numerous effects on the human body, characterized by a rush of energy, euphoria and empathy. However, also a multitude of toxic/neurotoxic effects have been ascribed to MDMA, based upon case reports and studies in animals. Given the intrinsic difficulties associated with controlled studies in human beings, most of our insights into the biology of MDMA have been gained through animal studies. The vast majority of these studies utilizes a pharmacological approach to elucidate the mechanisms by which MDMA exerts its effects.Advances in genetics during the last decade have led to the development of several mouse models (transgenic or knockout) that have greatly contributed to our understanding of MDMA biology. This review provides an overview of these genetically modified animal models, in the light of some characteristic effects of MDMA, e.g. hyperlocomotion, neurotoxicity, hyperthermia, behaviour or rewarding. Without a shadow of a doubt, the next decade will bring many more advanced animal models, such as mice with site-specific deletion or rescue of genes and more genetically modified rat models. These models will further improve our knowledge on the pharmacology and toxicity of MDMA and, possibly, may assist in developing therapies coping with potential damage in abusers of MDMA and other drugs, as well as in patients suffering from specific neuronal pathologies.MDMA in advanced animal models 3

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Methamphetamine- and 3,4-Methylenedioxymethamphetamine–Induced Behavioral Changes in Histamine H3–Receptor Knockout Mice

Cited by 30 publications

References 27 publications

Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice

Evidence for the Role of Histamine H3 Receptor in Alcohol Consumption and Alcohol Reward in Mice

Roles of Hypothalamic Subgroup Histamine and Orexin Neurons on Behavioral Responses to Sleep Deprivation Induced by the Treadmill Method in Adolescent Rats

Mice in Ecstasy: Advanced Animal Models in the Study of MDMA

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