Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults

Crane, Natania A.; Molla, Hanna; de Wit, Harriet

doi:10.1007/s00213-023-06398-4

Cited by 2 publications

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“…Importantly, within this sample, AMP+ reported higher depressive symptoms than the comparison group, leaving the potential influence of mood symptoms on the observed findings unclear. The acute administration of methamphetamine to healthy individuals has also recently been shown to increase activity within ventral striatum and anterior insula during loss anticipation (Crane et al, 2023;Molla et al, 2023). These findings suggest that amphetamine type stimulants and the associated use disorder alter neural reward responsivity and may have distinct effects on the processing of positive and negative stimuli.…”

Section: Introductionmentioning

confidence: 91%

Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward

May,

Burrows,

Kuplicki

et al. 2024

J Psychopharmacol

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Background: Dysregulated ventral striatum function has been proposed as one important process occurring in individuals with substance use disorder. This study investigates the role of altered reward and loss processing, which is an important component of impaired decision-making, impulsivity, and vulnerability to relapse in individuals with amphetamine use disorder (AMP). Aims: To determine whether AMP is associated with blunted striatum, prefrontal cortex, and insula signals during win and loss anticipation. Methods: Participants with and without AMP (AMP+ n = 46, AMP− n = 90) from the Tulsa 1000 study completed a monetary incentive delay (MID) task during functional magnetic resonance imaging. Results: Group main effects indicated that: (1) AMP+ exhibited lower bilateral caudate/putamen and left nucleus accumbens signal than AMP− across anticipation of wins and losses; and (2) AMP+ showed slower reaction times than AMP− during loss anticipation. Group*condition interactions demonstrated that AMP+ exhibited greater right amygdala signal than AMP− while anticipating large wins, a pattern that reversed when anticipating small losses. Left caudate/putamen attenuations in AMP+ during small loss anticipation were also evident. Groups did not differ in prefrontal or insula signals. Conclusions: AMP+ individuals have altered neural processing and response patterns during reward and loss anticipation, potentially reflecting impairments in dopamine function, which may influence their decision-making and reactions to different win/loss scenarios. These findings help to explain why AMP+ have difficulty with decision-making and exhibit a heightened focus on immediate rewards or punishments.

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Section: Introductionmentioning

confidence: 91%

Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward

May,

Burrows,

Kuplicki

et al. 2024

J Psychopharmacol

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“…Single doses of MA decreased neural activation in the nucleus accumbens during reward prediction error signals and in the ventromedial prefrontal cortex (vmPFC) during incentive value processing. A recent study from our lab using a monetary reward task found that a single dose of MA decreased nucleus accumbens activation during receipt of monetary reward in contrast to loss, and this effect was primarily due to an increased effect of the drug on receipt of losses ( Crane et al. 2023 ).…”

Section: Introductionmentioning

confidence: 99%

Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task

Molla

Keedy

DeBrosse

et al. 2023

Cerebral Cortex Communications

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Stimulants like methamphetamine (MA) affect motivated behaviors via actions on circuits mediating mood, attention and reward. Few studies examined the effects of single doses of stimulants on reward circuits during anticipation and receipt of rewards and losses. Here, we examined the effects of MA (20 mg) or placebo in a within-subject, double-blind study with healthy adults (n = 43). During two fMRI sessions participants completed the monetary incentive delay task. Primary outcome measures were BOLD activation in selected regions of interest during anticipation and receipt of monetary rewards and losses. Secondary analyses included behavioral measures, whole brain analysis and arterial spin labeling. MA produced its expected behavioral effects and increased neural activation in the ventral striatum and anterior insula during anticipation of monetary loss vs. non-loss. MA did not affect activation during anticipation of gains, or during receipt of wins or losses. MA significantly reduced cerebral blood flow in the striatum and insula. The present finding that a stimulant enhances the responses of striatal and insular regions to upcoming loss suggests this system may be sensitive to salience of upcoming events. The finding adds to a complex body of evidence regarding the effects of stimulant drugs on neural processes during motivated behaviors.

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Methamphetamine alters nucleus accumbens neural activation to monetary loss in healthy young adults

Cited by 2 publications

References 47 publications

Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward

Amphetamine use disorder is associated with striatum hypoactivation during anticipation of loss and reward

Methamphetamine enhances neural activation during anticipation of loss in the monetary incentive delay task

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