Methamphetamine administration during gestation impairs maternal behavior

Šlamberová, Romana; Charousová, Petra; Pometlová, Marie

doi:10.1002/dev.20042

Cited by 68 publications

(42 citation statements)

References 39 publications

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“…It is therefore not surprising that AMPH-treated voles demonstrated reduced pair bonding behavior. The current effects of AMPH exposure on pair bonding are consistent with previous studies illustrating the deleterious effects of psychostimulants on other social behaviors, including maternal behavior (45)(46)(47) and social play (48)(49)(50). Together, such work provides the promise that examination of how drug and social stimuli interact in the brain may significantly extend our understanding of the strong interactions between social behavior and drug use in humans (21).…”

Section: Discussionsupporting

confidence: 85%

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Liang

Aragona

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

119

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The prairie vole (Microtus ochrogaster) is a socially monogamous rodent species that forms pair bonds after mating, a behavior in which central dopamine (DA) has been implicated. Here, we used male prairie voles to examine the effects of drug exposure on pair bonding and related neural circuitry. In our first experiment, amphetamine (AMPH) motivated behavior was examined using a conditioned place preference (CPP) paradigm and was shown to be mediated by activation of D1-like DA receptors. Next, we examined the effects of repeated AMPH exposure on pair bonding. Intact and saline pretreated control males displayed mating-induced partner preferences, whereas males pretreated with AMPH at the doses effective to induce CPP failed to show mating-induced partner preferences. Such AMPH treatment also enhanced D1, but not D2, DA receptor expression in the nucleus accumbens (NAcc). Furthermore, pharmacological blockade of D1-like DA receptors in the NAcc rescued mating-induced partner preferences in AMPH-treated males. Together, our data indicate that repeated AMPH exposure may narrow the behavioral repertoire of male prairie voles via a DA receptor-specific mechanism in the NAcc, resulting in the impairment of pair bond formation.vole | CPP | D1 Receptor I t is widely accepted that motivated and emotional behaviors that promote fitness are regulated by brain reward circuitry including the mesolimbic dopamine (DA) system (1, 2). Although this system is often implicated in food intake and sexual behavior (3, 4), it has also been implicated in other naturally occurring motivated behaviors, such as social play between juveniles and social bonding between parent and offspring (5-9). Often underrepresented in research are the social bonds formed between adult mates, i.e., pair bonds. Recent investigation using a socially monogamous rodent species, the prairie vole (Microtus ochrogaster) (10-12), indicate that a great deal of the neural regulation underlying pair bond formation and maintenance occurs within the nucleus accumbens (NAcc) (13-15)-a mesolimbic brain region critical for mediating motivated behaviors (1, 2, 16).Although motivational circuitry evolved to promote fitness enhancing behavior such as feeding, mating, and social bonding (1, 17), it is vulnerable to artificial usurpation by drugs of abuse (8). For example, administration of psychostimulant drugs of abuse, such as cocaine and amphetamine (AMPH), results in persistent alterations of mesolimbic DA activity (18,19). The intense impact on this circuit by these and other addictive drugs has been suggested to decrease the perceived value of natural incentives (20), including those of a social nature (8). Although it is known that drug addicts show impaired social behavior (21), the neural regulation of interactions between drug experience and social attachment is poorly understood. This is because, in part, such interactions are difficult to model in traditional laboratory rodents that do not exhibit social bonding between adult conspecifics.The neurobiology of su...

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Section: Discussionsupporting

confidence: 85%

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Liang

Aragona

Young

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

119

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“…Animals were housed four per cage by sex and left undisturbed for a week in a temperaturecontrolled (22-24 • C) colony room with free access to food and water on a 12 h (light):12 h (dark) cycle with lights on at 06:00 h. Females were impregnated as described in our previous study [60]. In total, 24 dams were randomly assigned to either the MAtreated or saline-treated group.…”

Section: Animals and Drug Injectionsmentioning

confidence: 99%

“…On PD 1, pups were weighed, tattooed for identification, and cross-fostered (for detailed information see [30,60]). The pups were cross-fostered in such a way that each of the 24 mothers received and raised 12 pups -6 of which had been prenatally exposed to MA and 6 to saline.…”

Section: Animals and Drug Injectionsmentioning

confidence: 99%

Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Šlamberová

Pometlová

Macúchová

et al. 2015

Behavioural Brain Research

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“…Females were randomly assigned to M-treated (M), saline-treated (S) and control (C) groups. Subcutaneous (s.c.) injection of M (5 mg/kg) was administered daily approximately for 9 weeks: about 3 weeks prior to impregnation, throughout the entire gestation period and for 23 days of lactation period (until the weaning) (for details see Š lamberová, Charousová, & Pometlová, 2005b). The dose of 5 mg/kg was chosen based on the findings (Weissman & Caldecott-Hazard, 1995) that this dose alters locomotor and exploratory behaviors.…”

Section: Mothersmentioning

confidence: 99%

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

Hrubá

Schutová

Šlamberová

et al. 2008

Developmental Psychobiology

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The present study tested the hypothesis that cross-fostering influences the development of rat pups. Mothers were exposed daily to injection of methamphetamine (M) (5 mg/kg) or saline for 9 weeks: 3 weeks prior to impregnation, throughout gestation and lactation periods. Control females animals without any injections were used. On postnatal day (PD) 1, pups were cross-fostered so that each mother received four pups of her own and eight pups from the mothers with the other two treatments. Offspring were tested for sensorimotor development in preweaning period by using tests of: negative geotaxis, tail pull, righting reflexes, rotarod and bar-holding. Further, the pups were weighed daily. Our results showed that birth weight in prenatally M-exposed pups was lower than in control or saline-exposed pups. Prenatally M-exposed pups gained less weight than control or saline-exposed pups regardless of postnatal treatment and sex. Further, our data demonstrated that prenatal and postnatal M exposure impairs sensorimotor functions in most of the tests. On the other hand, the negative effect of prenatal M exposure was partially suppressed in prenatally M-exposed pups by cross-fostering to control dams. Our hypothesis that cross-fostering may affect postnatal development of pups was confirmed.

show abstract

Methamphetamine administration during gestation impairs maternal behavior

Cited by 68 publications

References 39 publications

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Nucleus accumbens dopamine mediates amphetamine-induced impairment of social bonding in a monogamous rodent species

Do the effects of prenatal exposure and acute treatment of methamphetamine on anxiety vary depending on the animal model used?

Effect of methamphetamine exposure and cross‐fostering on sensorimotor development of male and female rat pups

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