Methamphetamine abuse and dentistry

Hamamoto, Darryl T.; Rhodus, Nelson L.

doi:10.1111/j.1601-0825.2008.01459.x

Cited by 126 publications

(117 citation statements)

References 77 publications

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“…The chronic use of methamphetamine involves a wide range of potential health hazards including massive weight loss, chronic skin irritations, cardiovascular diseases, structural brain damage, paranoia, or depression (Hamamoto & Rhodus, 2009). Recently, however, the severe consequences of chronic methamphetamine abuse has been described and, in particular, those on the stomatognathic system, which consists of the mouth, teeth, intraoral tissue, and jaws (Curtis, 2006;Donaldson & Goodchild, 2006;Hamamoto & Rhodus, 2009).…”

Section: Consequences Of Chronic Methamphetamine Abusementioning

confidence: 98%

Evaluation of methamphetamine-associated socioeconomic status and addictive behaviors, and their impact on oral health

Rommel¹,

Rohleder²,

Wagenpfeil

et al. 2015

Addictive Behaviors

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Section: Consequences Of Chronic Methamphetamine Abusementioning

confidence: 98%

Evaluation of methamphetamine-associated socioeconomic status and addictive behaviors, and their impact on oral health

Rommel¹,

Rohleder²,

Wagenpfeil

et al. 2015

Addictive Behaviors

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“…4) Numerous studies have been performed to evaluate the most effective therapeutic methods to treat METH addiction through the long-lasting prevention of relapse to METH use without side effect. Some of these studies have investigated needle acupuncture, which has been used to treat various drug addictions in humans.…”

mentioning

confidence: 99%

Regulatory Effect of Bee Venom on Methamphetamine-Induced Cellular Activities in Prefrontal Cortex and Nucleus Accumbens in Mice

2015

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Our previous studies demonstrated that subcutaneous injection of bee venom (BV) into the Zusanli (ST36) acupuncture point, namely BV acupuncture, dose-dependently prevents conditioned place preference (CPP) induced by repeated injection of methamphetamine (METH) in mice. To expand on our observations, the present study was designed to determine the suppressive mechanisms of BV acupuncture in the development of METH-induced CPP by evaluating the changes in expression of ΔFosB, phosphorylated extracellular signal-regulated kinase 1/2 (pERK), and phosphorylated calcium/calmodulin-dependent protein kinase type II (pCaMKII) in the prefrontal cortex (PFC) and nucleus accumbens (NAc) in mice. Pre-emptive treatment with BV at 30 min before repeated METH injection completely suppressed acquisition of CPP at the day 7 test session. METH-induced upregulation of ΔFosB and pERK in PFC and NAc was significantly reduced by BV pretreatment. Expression of pCaMKII was significantly elevated by METH in NAc and reduced in PFC. BV pretreatment reversed the changes of pCaMKII expression in PFC and NAc. These findings suggest that BV acupuncture may exert a suppressive effect on METH-induced addiction via regulation of signaling cascades of ΔFosB, ERK, and CaMKII in PFC and NAc. Key words methamphetamine (METH); bee venom (BV); conditioned place preference (CPP); prefrontal cortex (PFC); nucleus accumbens (NAc)Addiction to methamphetamine (METH) is an international public health problem. Acute administration of METH results in a sense of euphoria and hyperactivity in association with increased extracellular release of monoamine neurotransmitters, including dopamine, norepinephrine and serotonin. 1,2) Chronic METH abuse produces several negative side effects, including dopaminergic nerve terminal toxicity, altered morphology in the central nervous systems and an increased risk of developing Parkinson's disease.3) Nevertheless, exacerbating the problem of METH-induced neurotoxicity is the current lack of Food and Drug Administration (FDA)-approved pharmacotherapies for treating the negative health effects of METH abuse. 4)Numerous studies have been performed to evaluate the most effective therapeutic methods to treat METH addiction through the long-lasting prevention of relapse to METH use without side effect. Some of these studies have investigated needle acupuncture, which has been used to treat various drug addictions in humans. However, most studies revealed that needle acupuncture produces a significant but only partial therapeutic effect compared with the placebo control. 5) Our recent studies firstly demonstrated that acupuncture with bee venom (BV), which is a potent peripheral stimulant that is dissolved in saline and administered into Zusanli acupuncture point (ST36), could dose-dependently reduce the hyperactivity induced by a single injection of METH as compared with other acupuncture points [Yinlingquan (SP9) and Xuanzhong (GB39)] or non-acupuncture point (tail base).6) This result indicated that BV injection into Zusanli a...

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“…Furthermore, meth intoxication increases dopamine levels, which can decrease saliva production, increase sugar consumption, and cause bruxism [44,86]. Methamphetamine also causes xerostomia, or dry mouth, which contributes to dental decay in meth users similar to that in Sjögren's syndrome [87]. Malnutrition, weight loss, and premature aging are other notable effects of methamphetamine.…”

Section: Methamphetaminementioning

confidence: 99%

Dermatologic Signs and Symptoms of Substance Abuse

Raiker¹,

Aouthmany²

2016

J Clin Exp Dermatol Res

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Various substances of abuse are known to cause specific cutaneous manifestations. In this review, we highlight the cutaneous manifestations associated with the use of cocaine, heroin, marijuana, methamphetamine, alcohol, and anabolic steroids. Cutaneous signs of tanning addiction are also discussed, as tanning bed use is a particularly relevant and growing problem in Dermatology. We also provide examples of general signs of drug abuse, including stigmata of injection drug use, vascular complications, and infectious complications. This review aims to make clinicians more aware of these signs in order to better recognize substance abuse disorders and guide effective treatment.

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Methamphetamine abuse and dentistry

Cited by 126 publications

References 77 publications

Evaluation of methamphetamine-associated socioeconomic status and addictive behaviors, and their impact on oral health

Evaluation of methamphetamine-associated socioeconomic status and addictive behaviors, and their impact on oral health

Regulatory Effect of Bee Venom on Methamphetamine-Induced Cellular Activities in Prefrontal Cortex and Nucleus Accumbens in Mice

Dermatologic Signs and Symptoms of Substance Abuse

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