2013
DOI: 10.1039/c3mt00150d
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Methallothionein-3 contributes to vascular endothelial growth factor induction in a mouse model of choroidal neovascularization

Abstract: In the present study, we investigated possible roles of the zinc (Zn)-binding protein metallothionein-3 (MT3) and cellular Zn in a mouse model of laser-induced choroidal neovascularization (CNV) using wild-type (WT) and MT3-knockout (KO) mice. Quantitative RT-PCR was used for the detection of MT3 mRNA. CNV was induced in mice between 8 and 12 weeks of age by disrupting the Bruch's membrane using an argon laser. Fundus photography and fluorescein angiography (FA) were performed 2 weeks following laser photocoag… Show more

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Cited by 12 publications
(8 citation statements)
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References 39 publications
(35 reference statements)
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“…1). In this study, we confirmed that hypoxia-inducible factor (HIF)-1α was stabilized in the nuclear fraction, but MT-1/2 was increased in the cytosol fraction under hypoxia, and that knockdown of MT-1 or MT-2 increased HIF-1α polyubiquitination 42) (Fig. 1).…”
Section: Diabetic Retinopathy (Dr)supporting
confidence: 72%
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“…1). In this study, we confirmed that hypoxia-inducible factor (HIF)-1α was stabilized in the nuclear fraction, but MT-1/2 was increased in the cytosol fraction under hypoxia, and that knockdown of MT-1 or MT-2 increased HIF-1α polyubiquitination 42) (Fig. 1).…”
Section: Diabetic Retinopathy (Dr)supporting
confidence: 72%
“…It has been previously indicated that MT-1/2 KO mice decreased expression of the growth factors tumor growth factor-β1 (TGF-β1), NT-3, basic fibroblast growth factor (b-FGF), and VEGF. 53) Furthermore, we first reported the involvement of MT-1/2 in retinal neovascularization 42) (Fig. 1).…”
Section: Diabetic Retinopathy (Dr)mentioning
confidence: 96%
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“…38 However, according to our findings and previous reports, not only MT-1/2-but also MT-3-deficient mice had exacerbated ocular angiogenesis. 39 These findings suggest that MT contributes to decrease of HIF-1a and VEGF expression, and this effect was stronger than the protective effects of RPE through antioxidative stress. Therefore, MT might promote angiogenesis.…”
Section: Discussionmentioning
confidence: 85%