Methaemoglobinaemia in acute indoxacarb poisoning

Lee, Dong Keon; Kim, Hyun; Sung, Yong

doi:10.1111/1742-6723.12402

Cited by 5 publications

(4 citation statements)

References 5 publications

(5 reference statements)

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“…A significant decrease was noticed in the RBC, Hg and HCT, on the contrary WBC was significantly increased (Sandeep et al, 2016). Similarly, Lee et al, (2015) reported a methemoglobinemia after indoxacarb ingestion because of the aromatic metabolites that were biotransformed in to the active intermediates. The lower values in erythrocyte counts and haemoglobin concentration might be referred to the failure to supply the blood circulation with cells from haemohepatic tissues, since the liver has an important role in the regeneration of erythrocyte and the possible destructive effect on erythrocyte by the toxicants.…”

Section: Discussionmentioning

confidence: 90%

Modulation of Abamectin and Indoxacarb -Induced Toxicity on Male Albino Rats by Moringa oleifera

Abdelrasoul¹

2018

Alexandria Science Exchange Journal

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Pesticide formulations are characterized by its complex mixtures.The available toxicity information on the active ingredients alone is not quit enough to evaluate the risk of undesirable health effects of commercial pesticides. Therefore, the present study was proposed to clarify the adverse effects of exposure to formulated abamectin (ABA) (0.5 mg/kg bw, 1/20 LD 50 ), indoxacarb (IND) (86.6 mg/kg bw, 1/20 LD 50 ) and their combinations on some haematological and biochemical parameters and histopathological changes of male rats given repetitive oral doses for 30 consecutive days. The protective effect of aqueous extract of Moringa oleifera leaves (MO) against toxicity induced by tested insecticide was, also, considered. Results indicated that ABA, IND, and their combination treatments, significantly, caused gradual decreasing in body weight, erythrocyte counts (RBCs), haemoglobin concentration (g/dL), haematocrit (%) and platelets (PLT). However, significant elevation in the relative liver, kidney and brain weights were associated with these treatments. Marked and significant increments in the levels of serum alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gammaglutamyltransferase ( -GT), glucose concentration and creatinine (Cre), while decrease in serum acetylcholinesterase (AChE) activity was observed due to tested insecticide treatments. Exposure to ABA and IND, significantly decrease the total protein and total antioxidant scavenging activity. Histological studies confirmed the biochemical parameters. M. oleifera leavestreated rats with ABA, IND or their combinations showed marked improvements of hematological, biochemical parameters and histopathological changes, indicating that MO extract bear a potent antioxidant activity. Therefore, the successive aqueous extract of MO as an herbal tea may be beneficial for patients who suffer from liver, kidney and brain diseases and restoring the damage sustained by insecticide exposure.

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Section: Discussionmentioning

confidence: 90%

Modulation of Abamectin and Indoxacarb -Induced Toxicity on Male Albino Rats by Moringa oleifera

Abdelrasoul¹

2018

Alexandria Science Exchange Journal

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“…Bu çalış-maların birinde Tusurubuchi ve ark., sıçan dorsal kök ganglionlarında 0,2, 1 ve 10 µm dozlarındaki indoksakarbın sodyum akımları üzerine etkisini incelemişlerdir. 11 0,2 µm indoksakarbın sodyum akımlarını etkilemediği, 1 µm'ın akımı %4,4 ve 10 µm'ın ise %46,6 oranında azalttığı belirlenmiştir. Zhao ve ark., izole hamam böceği dorsal kök nöron-larında tüm hücre "patch clamp" tekniğini kullanarak indoksakarbın ve metaboliti DCJW'nin Tip I ve Tip II sodyum akımları üzerine etkisini araştırmış-lardır.…”

Section: Discussionunclassified

“…İnsanlarda en sık görülen etkisi methemoglobinemidir. 10,11 Ayrıca Viswanathan ve ark. tarafından sunulan bir olguda indoksakarb zehirlenmesinin solunum sıkıntısının da eşlik ettiği periferik nöro-pati ve turuncu idrar bulgularının da ortaya çıktığı bildirilmiştir.…”

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Effect of Indoxacarb on Isolated Frog Skeletal Muscle

Çömelekoğlu¹,

Ballı²,

Kurutaş³

et al. 2017

Turkiye Klinikleri J Lab Anim

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“…In contrast with our results, Abdelrasoul (2018) documented that indoxacarb significantly decreased the RBC counts, Hb content, and Hct value but significantly increased the WBC counts. Also, Lee et al (2015) proposed that the reduction in erythrocyte counts and,therefore, the hemoglobin concentration might be attributed to methemoglobinemia. On the other hand, the increased RBC count, Hb content, Hct value, MCV, WBC counts, and platelet counts in our study might be obtained as the result of polycythemia.…”

Section: Evaluation Of Hormonal Parametersmentioning

confidence: 99%

The Toxic Effect of Indoxacarb Exposure on Some Hematological and Hormonal Indices and Evaluating the Potential Alleviative Effects of Vitamin C and Zinc in Male Albino Rats

Hassan

Meligi

2021

Egyptian Academic Journal of Biological Sciences, B. Zoology

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The world is facing very severe disasters, most notably the toxic effects of pesticides on living organisms' health and the environment, whether directly or indirectly and in the short or long term. Some developing countries suffer from severe shortcomings regarding the necessary precautions to reduce the potential toxicity risks from handling or exposure to pesticides. This work achieved to study the toxic effect of sub-lethal dose of indoxacarb (100 mg/kg) exposure and evaluate the protective effects of vitamin C (200 mg/kg) and zinc (Zn) (100 mg/kg) (separately or together) in male albino rats. The experimental rats were randomly divided into five groups (n=6): control group, indoxacarbtreated group, indoxacarb+vitamin C-treated group, indoxacarb+Zn-treated group, and indoxacarb+vitamin C+Zn-treated group. All groups received orally the tested doses every 48 h for 21 days. The results indicated that indoxacarb induced significant changes of some hematological parameters (red blood cells (RBC) counts, white blood cells (WBC) counts, hemoglobin (Hb) content, hematocrit (Hct) value, mean corpuscular volume (MCV) and platelets counts) besides substantial alterations in the thyroid hormones (triiodothyronine (T3), thyroxine (T4), and thyroid-stimulating hormone (TSH)) and the sex hormones (total and free testosterone, progesterone, and estradiol). Furthermore, the administration of vitamin C and zinc together alleviated the alteration of later hematological and hormonal parameters in indoxacarbtreated rats. Conclusion: a mixture of vitamin C and zinc may show ameliorating effects against indoxacarb-toxicity through improving the examined biochemical parameters about the use of both alone.

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Methaemoglobinaemia in acute indoxacarb poisoning

Cited by 5 publications

References 5 publications

Modulation of Abamectin and Indoxacarb -Induced Toxicity on Male Albino Rats by Moringa oleifera

Modulation of Abamectin and Indoxacarb -Induced Toxicity on Male Albino Rats by Moringa oleifera

Effect of Indoxacarb on Isolated Frog Skeletal Muscle

The Toxic Effect of Indoxacarb Exposure on Some Hematological and Hormonal Indices and Evaluating the Potential Alleviative Effects of Vitamin C and Zinc in Male Albino Rats

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