Methadone depression of visual signal detection performance

Rothenberg, Stephen J.; Peck, Emily; Schottenfeld, S.; Betley, G.E.; Altman, Jack

doi:10.1016/0091-3057(79)90035-2

Cited by 33 publications

(9 citation statements)

References 14 publications

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“…However, one patient (5) had delayed pattern-reversal VEPs despite absence of nystagmus. It is possible that the pattern VEP delay is related to methadone exposure10: both acute and maintenance methadone treatment delay the pattern-reversal VEP in adults 8 10 23. Opioid signalling plays a role in myelination and axonal growth, which could affect VEP latency 24…”

Section: Discussionmentioning

confidence: 99%

Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy

Hamilton

McGlone

MacKinnon

et al. 2010

British Journal of Ophthalmology

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Section: Discussionmentioning

confidence: 99%

Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy

Hamilton

McGlone

MacKinnon

et al. 2010

British Journal of Ophthalmology

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“…This suggests that the visual system is subject to opiate modulation. Previous research has shown that morphine‐like drugs can alter visual discrimination performance in rats, 7 evoke cortical potentials in cats 8 and reduce visual sensitivity in humans 9 . Recent studies have also revealed that chronic morphine exposure induces degradation of the receptive field properties of the LGN and primary visual cortex (V1) cells in cats 10,11 .…”

Section: Introductionmentioning

confidence: 99%

Chronic Morphine Exposure Affects Visual Response Latency of the Lateral Geniculate Nucleus in Cats

Long

Liang

et al. 2008

Clin Exp Pharma Physio

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Chronic morphine exposure results in degradation of the functional properties of cortical cells. However, little evidence has been reported about the effect of morphine on the temporal properties of the visual system. We compared the visual response latency of different cells of the lateral geniculate nucleus (LGN) in morphine (10 mg/mL)- and saline-treated cats. Morphine-treated cats were given morphine sulphate by cervical subcutaneous injection twice daily for 10 days, whereas saline-treated cats received injections of 0.9% saline instead. We found that LGN neurons in morphine-treated cats exhibited significantly longer response latency than those in saline-treated cats (P < 0.001). To investigate whether different types of neurons exhibited similar changes in response to morphine, we classified LGN neurons as on- and off-centre, X and Y, and layer A, A1 and C neurons. There was a tendency for prolonged latency in layer C neurons and a significantly longer latency for the other neurons in morphine-treated cats (P < 0.05). These findings suggest that chronic morphine administration (10 mg/kg by cervical subcutaneous injection twice daily for 10 days) delays information transfer earlier in the visual pathway.

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“…It has been suggested that the visual system is subject to opiate modulation. Previous studies have shown that morphine-like drugs decrease visual sensitivity in humans [4] , affect visual discrimination performance in rats [5] , and evoke cortical potentials by stimulating the optic chiasm in cats [6] . Repeated use of addictive drugs leads to multiple adaptive neuronal responses [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Chronic morphine exposure induces degradation of receptive field properties of LGN cells in cats1

et al. 2005

Acta Pharmacologica Sinica

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Aim: To investigate the effect of chronic morphine exposure on the receptive field properties of lateral geniculate nucleus (LGN) neurons in cats. Methods: Cats were injected with morphine (10 mg/kg) or saline twice daily, for 10 d. Subsequently, extracellular single‐unit recording techniques were used to examine the sensitivity of LGN neurons to visual stimuli in chronic morphine‐treated and saline‐treated cats. Results: Compared with saline‐treated cats (as controls), LGN neurons in morphine‐treated cats had decreased signal‐to‐noise ratios (1.9 vs 3.1), and orientation and direction sensitivity (0.103 vs 0.135 and 0.074 vs 0.10, respectively), accompanied by significant increases in spontaneous (27.4 vs 17.5) and evoked activity (preferred: 42.2 vs 38.1; average: 28.1 vs 22.3). Conclusion: Chronic morphine exposure can lead to the functional degradation of LGN neurons in cats, which might result from the effects of chronic morphine exposure on inhibitory neurotransmission.

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Methadone depression of visual signal detection performance

Cited by 33 publications

References 14 publications

Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy

Ophthalmic, clinical and visual electrophysiological findings in children born to mothers prescribed substitute methadone in pregnancy

Chronic Morphine Exposure Affects Visual Response Latency of the Lateral Geniculate Nucleus in Cats

Chronic morphine exposure induces degradation of receptive field properties of LGN cells in cats1

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