Methadone and edema: a case-report and literature review

Mahé, Isabelle; Chassany, Olivier; Grenard, Anne-Sophie; Caulin, C; Bergmann, Jean‐François

doi:10.1007/s00228-003-0712-1

Cited by 12 publications

(6 citation statements)

References 4 publications

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“…Calcineurin inhibitors: 36 ciclosporin, tacrolimus Increased capillary permeability (as these drugs are responsible for capillary leak syndrome) mTOR inhibitors: 53 everolimus, sirolimus -lymphedema through antilymphangiogenic effects of VEGFR-3/VEGFC pathway inhibition 53 -increased capillary permeability 121 Pump proton inhibitors 122,123 lansoprazole, omeprazole, pantoprazole, rabeprazole Unknown Opioids Analgesics: [124][125][126] fentanyl, hydromorphone, morphine, oxycodone, tramadol -increased capillary permeability through nonspecific histamine releasing effects 124,127 -water retention through AVP release 125,127 Replacement therapy: methadone 127,128 Hypoglycemic sulfonamides: 129,130 Unknown thymoglobulin 36 Increased capillary permeability (as responsible for capillary leak syndrome)…”

Section: Immunosuppressantsmentioning

confidence: 99%

Drug‐induced peripheral oedema: An aetiology‐based review

Largeau

Cracowski

Lengelle

et al. 2021

Brit J Clinical Pharma

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Section: Immunosuppressantsmentioning

confidence: 99%

Drug‐induced peripheral oedema: An aetiology‐based review

Largeau

Cracowski

Lengelle

et al. 2021

Brit J Clinical Pharma

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“…The rash is often pruritic and purpuric or exanthematous in character and appears on the trunk, hands, feet and lower limbs for a period of 7 days. Some patients undergo a desquamative phase following this, which can last up to 4 weeks . While it still has to be determined whether this is due to hypersensitivity or contamination of methadone, it is important for all physicians to be aware of the association of rash with methadone.…”

Section: Discussionmentioning

confidence: 99%

Methadone complications amongst opioid‐dependent patients in Malaysia: A case series

George

Vicknasingam

Thurairajasingam

et al. 2016

Drug and Alcohol Review

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Despite methadone being an effective therapy for opioid dependence, there is a need for other alternative effective therapies, such as naltrexone, buprenorphine and the co-formulation of buprenorphine-naloxone, to be made available to physicians in both public and private sectors. There is need for individual treatment consideration to avoid adverse effects, drug-drug interactions, overdosing and in the presence of co-morbidities. An emphasis on safe storage of takeaway methadone is also needed. [George P, Vicknasingam B, Thurairajasingam S, Ramasamy P, Mohd Yusof H, Yasin MABM, Shah ZUBS. Methadone complications amongst opioid-dependent patients in Malaysia: A case series. Drug Alcohol Rev 2018;37:147-151].

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“…1 There have been five publications describing a potential link with methadone in non-palliative care setting and peripheral oedema. [2][3][4][5][6] The earliest being Longwell 2 who describes three patients prescribed methadone for treatment of opioid addiction. All develop peripheral oedema within three to six months of commencing methadone, and in all cases, the oedema improves with subsequent reduction or stopping of methadone maintenance treatment.…”

Section: Discussionmentioning

confidence: 99%

“…There have been five published cases of the development of peripheral oedema following methadone, where most of these relate to methadone maintenance therapy. [2][3][4][5][6] This is the first report on the development of significant peripheral oedema following methadone treatment for neuropathic pain in the palliative care setting. The oedema subsequently resolved following cessation of methadone.…”

Section: Introductionmentioning

confidence: 95%