Methadone and Dexmedetomidine Combination as Premedicant Agents for Ovariectomy in Cats

Briganti, Angela; Breghi, Gloria; Vannozzi, Iacopo; Tayari, Hamaseh

doi:10.3844/ajavsp.2015.101.111

Cited by 5 publications

(1 citation statement)

References 39 publications

(53 reference statements)

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“…In all cats, no side effects related to the drugs used were seen, and recovery was always fast and excellent, as previously reported by other researchers (Bruniges et al, 2016; Pisu et al, 2017; Tayari et al, 2015). Moreover, as described by Ko et al (2009) and Pisu et al (2017), in both groups, all the cats were standing within 20 min of atipamezole administration and none of the cats vomited.…”

Section: Discussionmentioning

confidence: 99%

Comparison of two pharmacological semen collection times with α2‐adrenergic agonist in domestic cats

Hidalgo,

de Almeida,

dos Santos Silva

et al. 2023

Reprod Domestic Animals

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The use of α2‐adrenergic agonists in association with urethral catheterization has been used as a technique for pharmacological semen collection in cats. The mechanism of action of this drug is the stimulation of adrenoreceptors in the vas deferens, which results in ejaculation. While medetomidine is the α2‐agonist most commonly used in studies, ejaculation with the use of dexmedetomidine associated with ketamine has been effective, but with variable results. Therefore, further studies regarding the methodology of use are required to obtain better seminal quality. This study aimed to compare two pharmacological semen collection times after the association of dexmedetomidine (30 μg/kg, IM; Dormitor®, Zoetis), ketamine (5 mg/kg, IM; ketamine, Vetnil) and urethral catheterization using a tomcat probe (0.8 mm × 1.00 mm × 11 cm). The collections were divided into two experimental groups: G10 (N = 8; urethral catheterization after 10 min of anaesthesia) and G15 (N = 8; urethral catheterization after 15 min of anaesthesia). The ejaculates were evaluated for ejaculate volume, sperm concentration, morphology and kinetics using the CASA system. To compare the groups, the t‐test and the Mann–Whitney U‐test were used with a significance level of 5%. It was identified that ejaculate volume (G10: 22.62 ± 2.13 vs. G15: 26.81 ± 1.55; p < .001) and sperm concentration (G10: 48.10 × 106 ± 17.84 vs. G15: 90.18 × 106 ± 19.35; p < .001) was higher in G15 than in G10 and had a lower percentage of minor defects than G10 (G10: 3.12 ± 2.41 vs. G15: 1.00 ± 1.19; p = .043). Regarding the kinetic parameters, the results of G15 were better for total motility—TM (G10: 67.00 ± 10.33 vs. G15: 81.87 ± 7.99; p = .006) and faster cells—RAPID: (G10: 55.00 ± 16.63 vs. G15: 74.25 ± 11.94; p = .019); whereas a higher proportion of cells with slow speed—SLOW were seen in G10 (G10: 31.00 ± 12.07 vs. 17.12 ± 7.53; p = .015). Based on these findings, we suggest that collection via urethral catheterization should be performed 15 min after the application of ketamine‐associated dexmedetomidine to obtain a better‐quality ejaculate.

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Section: Discussionmentioning

confidence: 99%

Comparison of two pharmacological semen collection times with α2‐adrenergic agonist in domestic cats

Hidalgo,

de Almeida,

dos Santos Silva

et al. 2023

Reprod Domestic Animals

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Usefulness of an injectable anaesthetic protocol for semen collection through urethral catheterisation in domestic cats

Pisu¹,

Ponzio

Rovella³

et al. 2016

Journal of Feline Medicine and Surgery

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Objectives Although less often requested in comparison with dogs, the collection of semen in cats can be necessary for artificial insemination, for semen evaluation in tom cats used for breeding and for semen storage. Urethral catheterisation after pharmacological induction with medetomidine has proved to be useful for the collection of semen in domestic cats. However, most of the previously used protocols require the administration of high doses of medetomidine that can increase the risk of side effects, especially on the cardiovascular system. In routine clinical practice, one safe and useful injectable anaesthetic protocol for short-term clinical investigations or surgery in cats involves premedication with low intramuscular doses of dexmedetomidine with methadone, followed by intravenous propofol bolus injection. We aimed to assess the usefulness of this injectable anaesthetic protocol for semen collection, via urethral catheterisation, in domestic cats. Methods The study was performed on 38 purebred, adult cats, during the breeding season, and semen was collected via urethral catheterisation using an injectable anaesthesia protocol with methadone (0.2 mg/kg) and dexmedetomidine (5 µg/kg) premedication, followed by induction with propofol. Results The anaesthetic protocol used in the present study allowed the collection of large-volume semen samples, characterised by good parameters and without side effects. Conclusions and relevanceThe results from the present study suggest that the injectable anaesthetic protocol using methadone and dexmedetomidine premedication, followed by induction with propofol, could be suitable and safe for the collection of a good-quality semen sample, via urethral catheterisation, in domestic cats. It can therefore be used as an alternative to previous medetomidine-based sedation protocols.

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Comparison of the effect of three intramuscular sedation protocols on packed cell volume and total protein in cats

Skelding¹,

Valverde

2021

Journal of Feline Medicine and Surgery

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Objectives The aim of this study was to evaluate the change in packed cell volume (PCV) and total protein following intramuscular preanesthetic sedation with one of three drug combinations in cats. Methods Thirty client-owned cats were enrolled in this prospective, randomized, blinded, clinical study. A venous blood sample was obtained prior to administration of any sedation and PCV, total protein, electrolytes (Na+, K+, Cl–, iCa2+), glucose and lactate were measured. Cats were randomly assigned to receive one of three intramuscular sedation protocols (n = 10 cats/protocol): methadone 0.2 mg/kg + acepromazine 0.02 mg/kg (MA), methadone 0.2 mg/kg + dexmedetomidine 5 µg/kg (MD) or methadone 0.2 mg/kg + midazolam 0.2 mg/kg + alfaxalone 2 mg/kg (MMA). Twenty-five minutes later, cats were assessed for level of sedation followed by another venous blood sampling to evaluate the same variables as above. Results There were no significant differences in demographics (age, weight, sex) between groups. Level of sedation was significantly higher in MMA cats. Within groups, after premedication, PCV and hemoglobin significantly decreased in all groups, total protein significantly decreased in the MA and MMA groups and glucose significantly increased in the MD group. For electrolytes, statistical changes were not clinically relevant; Cl– mean difference was significantly different between MA and MD; in the MD group Na+ and Cl– significantly decreased and in the MMA group Cl– significantly increased. Conclusions and relevance All three sedation protocols caused significant decreases in PCV and hemoglobin in healthy cats.

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Methadone and Dexmedetomidine Combination as Premedicant Agents for Ovariectomy in Cats

Cited by 5 publications

References 39 publications

Comparison of two pharmacological semen collection times with α2‐adrenergic agonist in domestic cats

Comparison of two pharmacological semen collection times with α2‐adrenergic agonist in domestic cats

Usefulness of an injectable anaesthetic protocol for semen collection through urethral catheterisation in domestic cats

Comparison of the effect of three intramuscular sedation protocols on packed cell volume and total protein in cats

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