Methacrylate Derivatives Incorporating Pyroglutamic Acid

Smith, Tara J; Mathias, Lon J.

doi:10.1021/bm025663i

Cited by 4 publications

(1 citation statement)

References 20 publications

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“…2-Substituted methacrylates have been successfully homopolymerized. − Template loading in molecularly imprinted polymers, however, is typically 1−2%. For diagnostic applications, loadings can be substantially less.…”

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confidence: 99%

Novel Trifunctional Building Blocks for Fluorescent Polymers

Batra

Shea

2003

Org. Lett.

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confidence: 99%

Novel Trifunctional Building Blocks for Fluorescent Polymers

Batra

Shea

2003

Org. Lett.

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Pyrrolidone Monomers with Acrylate Functionality and their Polymers

Fernyhough¹,

Petty²,

Cunningham

et al. 2021

Handbook of Pyrrolidone and Caprolactam Based Materials

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This chapter reviews acrylate monomer chemistry, and summarizes reported work on the syntheses of acrylate and methacrylate monomers bearing pyrrolidone rings and their homo‐polymers and statistical copolymers made via conventional radical polymerizations. Acrylates are derivatives of acrylic acid – the simplest conjugated unsaturated carboxylic acid. Early laboratory methods developed for synthesizing (meth)acrylic esters of lactams, were based on the use of sodium derivatives of the lactams, including pyrrolidone. The chapter describes the use of the pyrrolidonyl acrylate/methacrylate monomers in the synthesis of structured block copolymers bearing pyrrolidone functionalities – that is, block copolymers based on pyrrolidonyl acrylate and methacrylate monomers synthesized via controlled living radical polymerization processes. Polymerization‐induced self‐assembly (PISA) has become established as a powerful and versatile method for the synthesis of amphiphilic diblock copolymer nanoparticles and various associated structured morphologies. PISA is extremely convenient and removes the need for post‐polymerization processing to induce self‐assembly.

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Synthesis of bio-degradable poly(2-hydroxyethyl methacrylate) using natural deep eutectic solvents for sustainable cancer drug delivery

Pradeepkumar

Subbiah²,

Rajan

2019

SN Appl. Sci.

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The primary metabolites frequently used for various applications including medicinal applications. Currently, natural deep eutectic solvents (NADESs) is prepared through primary metabolites and it is a good solvent with better biocompatibility, biodegradability, and non-toxic nature. In the current study, NADES was designed and used for the polymerization to drug carrier synthesis. The maximum quantity of poly(HEMA) was obtained by the stoichiometric ratios of choline chloride and xylitol (1:1) of NADES. The NADES-poly(HEMA) was attempted as a carrier with loaded 5-fluorouracil (5-FU). The NADES formation and PHEMA were characterized by proton nuclear magnetic resonance (1 H NMR), Fourier-transform infrared spectroscopy. The phase purity of synthesised NADES-poly(HEMA) and 5-FU loaded NADES-poly(HEMA) carrier was investigated by X-ray diffraction. Furthermore, the scanning electron microscope exhibited as-synthesised NADESpoly(HEMA) and 5-FU loaded NADES-poly(HEMA) was smooth with interconnected porous morphology. The encapsulation efficiency of the carrier was obtained 77 ± 1% and in vitro of 5-FU release from NADES-poly(HEMA) carrier was achieved in various physiological environment. Biodegradability of NADES-poly(HEMA) carrier was determined in the presence of esterase enzyme. The enhanced cytotoxicity of 5-FU-loaded NADES-poly(HEMA) was investigated against HeLa cancer cell line. Thus, the newly developed 5-FU loaded NADES-poly(HEMA) carrier is suitable for cancer treatment over a prolonged period of drug release.

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Methacrylate Derivatives Incorporating Pyroglutamic Acid

Cited by 4 publications

References 20 publications

Novel Trifunctional Building Blocks for Fluorescent Polymers

Novel Trifunctional Building Blocks for Fluorescent Polymers

Pyrrolidone Monomers with Acrylate Functionality and their Polymers

Synthesis of bio-degradable poly(2-hydroxyethyl methacrylate) using natural deep eutectic solvents for sustainable cancer drug delivery

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