Methacrylate and acrylate allergy in dental personnel

Abstract

2-HEMA was the most important allergen in dentists and dental nurses, and MMA and EGDMA in dental technicians. Reactions to bis-GMA, DEGDA, TREGDA, EMA and EA were relevant in some patients.

Occupational Contact Dermatitis Amongst Dentists and Dental Technicians

“…Acrylic monomersacrylates (potent sensitizers whose capacity reduces signifi cantly after polymerization), methacrylates, urethane acrylates and epoxy acrylates are used in dentistry in prostheses, dental adhesives, dental connective materials and glass ionomers. During the 1990s, a signifi cant increase in contact allergies to methacrylates was recorded, as well as occupational allergies to acrylic monomers 35 . Allergic CD caused by acrylates and methacrylates is traditionally considered to be primarily an occupational disease that mostly occurs amongst dental personnel, but also in other practices.…”

“…Among other signifi cant reactions, allergic CD caused by acrylates and methacrylates stands out for causing occupational and non-occupational allergic CD. Several investigations of contact allergies to (meth)acrylates among dental personnel have been performed 35,36 . In dentistry, acrylics are used to make dentures and other prostheses, for repair of fractured prostheses, and they are strong occupational sensitizers (especially for dental personnel).…”

Atypical pattern of (meth)acrylate allergic contact dermatitis in dental professionals

“…Concomitant sensitisations may also occur. 5,6 A positive patch test to a (meth)acrylate, when dealing with materials known to contain this group of chemicals, should be sufficient to make a diagnosis of ACD.…”

Relationships between the Reduced Glutathione (GSH) Reactivity of Dental Methacrylates, Michael-reaction Acceptors and their 13C-NMR Chemical Shift of -Carbons

“…By and large, methacrylate monomers don't polymerize totally in air since oxygen goes about as a biradical and stifles polymerization, leaving unreacted methacrylate bunches on the gum surface [1]. In this way unpolymerized methacrylates in dental materials are an essential element bringing on bothering and unfavorably susceptible responses in the oral hole [2][3][4]. Contingent upon the lipophilicity (octanol-water segment coefficient, log P) of monomers, they will live prevalently in the cell layers of oral tissues.…”

“…Since the organic frameworks are hetrogenous conditions, the hydrophobicity of monomers influences significantly more cytotoxicity than the hydrophilicity. Notwithstanding log P, , −unsaturated carbonyl methacrylates utilized as tar monomers may display danger however response with tissue nucleophiles by means of Michael expansion [2][3][4][5][6] (Figure 1). Acrylates are notable to be substantially more electrophilic than methacrylates, and have been beforehand answered to have high danger [5][6][7].…”