Methacholine dose response curve and acceptability criteria of respiratory mechanics modeling

Vitorasso, Renato; Mori, Vitor; Oliveira, Maria Aparecida de; Suaiden, Andre S; Tavares-de-Lima, Wothan; Moriya, Henrique Takachi

doi:10.1080/01902148.2020.1711831

Cited by 5 publications

(5 citation statements)

References 13 publications

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“…Thereby, the animal must be orally intubated 9 or submitted to tracheostomy. 8 The animal utilized for the experiment must be appropriately sedated. The sedation will lower the pain and distress of the studied animal and the plane of anesthesia will prevent the pain, a more controlled procedure takes place, and there is minimum interference in the animal’s respiration efforts because many anesthetics depress the respiratory system activity.…”

Section: Anestheticsmentioning

confidence: 99%

“…Thus, in such cases, the CPM may be applied under non-ideal circumstances. 51 This nonlinear behavior can be influenced by the MCh dose, 8 and the doses used in bolus can be up to 3 mg/kg (Table 1). The nonlinearities increase with an increase in the dose.…”

Section: Bronchoconstrictorsmentioning

confidence: 99%

“…Thus, to acquire more precise and controlled signals and parameters, the majority of studies use PPV with anesthesia to model the respiratory system during the respiratory mechanics evaluation. [6][7][8] In this scenario, a few drugs become relevant. These drugs can be categorized as anesthetics, muscle blockers, bronchoconstrictors, and bronchodilator.…”

Section: Impact Statementmentioning

confidence: 99%

“…In these studies, we have evaluated airway resistance, tissue viscance, and tissue elastance using the CPM in animal models of Parkinson's disease, asthma, and epilepsy. 8,[26][27][28] From the existing literature, intraperitoneal (i.p.) ketamine doses can range from 120 to 450 mg/kg.…”

Section: Ketaminementioning

confidence: 99%

“…Additionally, in mice under severe bronchoconstriction, an increase in the harmonics distortion index was observed, which estimates the nonlinear behavior of the respiratory system near the observed peak value. 8 This information is relevant with respect to mathematical modeling because the CPM used in the later work is a linear model. Thus, in such cases, the CPM may be applied under non-ideal circumstances.…”

Section: Mch Bolusmentioning

confidence: 99%

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Drug class effects on respiratory mechanics in animal models: access and applications

Oliveira

Lino-Alvarado

Moriya

et al. 2021

Exp Biol Med (Maywood)

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Assessment of respiratory mechanics extends from basic research and animal modeling to clinical applications in humans. However, to employ the applications in human models, it is desirable and sometimes mandatory to study non-human animals first. To acquire further precise and controlled signals and parameters, the animals studied must be further distant from their spontaneous ventilation. The majority of respiratory mechanics studies use positive pressure ventilation to model the respiratory system. In this scenario, a few drug categories become relevant: anesthetics, muscle blockers, bronchoconstrictors, and bronchodilators. Hence, the main objective of this study is to briefly review and discuss each drug category, and the impact of a drug on the assessment of respiratory mechanics. Before and during the positive pressure ventilation, the experimental animal must be appropriately sedated and anesthetized. The sedation will lower the pain and distress of the studied animal and the plane of anesthesia will prevent the pain. With those drugs, a more controlled procedure is carried out; further, because many anesthetics depress the respiratory system activity, a minimum interference of the animal’s respiration efforts are achieved. The latter phenomenon is related to muscle blockers, which aim to minimize respiratory artifacts that may interfere with forced oscillation techniques. Generally, the respiratory mechanics are studied under appropriate anesthesia and muscle blockage. The application of bronchoconstrictors is prevalent in respiratory mechanics studies. To verify the differences among studied groups, it is often necessary to challenge the respiratory system, for example, by pharmacologically inducing bronchoconstriction. However, the selected bronchoconstrictor, doses, and administration can affect the evaluation of respiratory mechanics. Although not prevalent, studies have applied bronchodilators to return (airway resistance) to the basal state after bronchoconstriction. The drug categories can influence the mathematical modeling of the respiratory system, systemic conditions, and respiratory mechanics outcomes.

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Section: Anestheticsmentioning

confidence: 99%

Section: Bronchoconstrictorsmentioning

confidence: 99%