Metformin With Either Histamine H2-Receptor Antagonists or Proton Pump Inhibitors: A Polypharmacy Recipe for Neuropathy via Vitamin B12 Depletion

Zdilla, Matthew J.

doi:10.2337/diaclin.33.2.90

Cited by 18 publications

(16 citation statements)

References 52 publications

(72 reference statements)

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“…To complicate matters, medications commonly used for treatment of diet‐ and lifestyle‐related conditions may contribute to neuropathy (Fig. ) . Some medications, such as proton‐pump inhibitors, H2 blockers, and metformin, are associated with reduced absorption of B vitamins .…”

Section: Medication‐induced Nutrient Depletion and Neuropathymentioning

confidence: 99%

“…For those of older age, there is often a concomitant use of medications that contribute to nutrient depletion in addition to having a decreased ability to absorb vitamin B 12 due to reduced stomach acid . Therefore, neuropathy that is assumed to be “diabetic” may in fact be at least partially secondary to B 12 deficiency . Furthermore, statin medication (often used for patients with metabolic syndrome and dyslipidemia) is associated with an increased risk of diabetes …”

Section: Medication‐induced Nutrient Depletion and Neuropathymentioning

confidence: 99%

“…39,[47][48][49][50][51][52] Some medications, such as proton-pump inhibitors, H2 blockers, and metformin, are associated with reduced absorption of B vitamins. 49,[51][52][53][54] Drug-induced nutrient depletion is more common than has been previously acknowledged. 55 For those of older age, there is often a concomitant use of medications that contribute to nutrient depletion in addition to having a decreased ability to absorb vitamin B 12 due to reduced stomach acid.…”

Section: Medication-induced Nutrient Depletion and Neuropathymentioning

confidence: 99%

“…56 Therefore, neuropathy that is assumed to be "diabetic" may in fact be at least partially secondary to B 12 deficiency. 51,52 Furthermore, statin medication (often used for patients with metabolic syndrome and dyslipidemia) is associated with an increased risk of diabetes. 57,58…”

Section: Medication-induced Nutrient Depletion and Neuropathymentioning

confidence: 99%

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Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives

Rowin

2019

Muscle and Nerve

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Complementary and alternative treatment modalities are commonly utilized by patients for neuropathy and neuropathic pain due to perceived lack of benefit from conventional medical treatment. As the association between metabolic syndrome and neuropathy is increasingly recognized, diet and lifestyle interventions are becoming important components in the management of neuropathy. Progress in the understanding of the gut–immune interaction highlights the role the gut microbiome and inflammation plays in the modulation of neuropathy and neuropathic pain. Evidence for nutritional interventions, exercise, supplements, acupuncture, and mindfulness‐based practices in the treatment of neuropathic pain is encouraging. This article reviews the available evidence to support the safe use of complementary and alternative treatments for commonly encountered conditions associated with neuropathy and neuropathic pain. Muscle Nerve 60: 124–136, 2019

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Section: Medication‐induced Nutrient Depletion and Neuropathymentioning

confidence: 99%

Section: Medication‐induced Nutrient Depletion and Neuropathymentioning

confidence: 99%

Section: Medication-induced Nutrient Depletion and Neuropathymentioning

confidence: 99%

Section: Medication-induced Nutrient Depletion and Neuropathymentioning

confidence: 99%

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Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives

Rowin

2019

Muscle and Nerve

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“…PPIs are used during chemotherapy to assist with reflux and could have an impact on vitamin B12 absorption. In addition, metformin is another drug that has been found to decrease vitamin B12 and in combination with either histamine H2-receptor antagonists or PPIs, neuropathy due to vitamin B12 depletion has been found [39].…”

Section: Identify Certain Nutrient Deficiencies From Chemotherapy Admmentioning

confidence: 99%

Cancer Treatment and Nutritional Deficiencies

Schloss¹

2016

Nutritional Deficiency

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Increasing cancer incidence and improved survival rates have seen the number of cancer survivors increase exponentially throughout the last few decades. As a consequence of this, cancer survivors may experience a number of permanent side effects from their cancer or the treatment. Traditionally, patient follow-up has been undertaken by oncological specialists with a major focus on possible cancer reoccurrence however, this fails to identify or adequately address many patients concerns regarding post-cancer treatment. For a majority of patients, nutrition during treatment and post-cancer diagnosis and treatment is an area they can control and change for their own health and well-being. The following chapter addresses nutrient deficiencies associated with certain cancers, chemotherapy agents, radiation and surgical procedures. Potential treatment protocols for different oncological stages post diagnosis are explored and conditions that may induce nutrient deficiencies and how they can be treated or decreased are explained.Keywords: chemotherapy, radiation, cancer survivorship, nutrient deficiencies, wellbeing . IntroductionIncreasing cancer incidence and improved survival rates have seen the number of cancer survivor s increase exponentially throughout the last few decades. As a consequence of this, cancer survivors may experience a number of permanent side effects from their cancer or the treatment [ ]. Traditionally, patient follow-up has been undertaken by oncological specialists © 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. with a major focus on possible cancer reoccurrence however, this fails to identify or adequately address many patients concerns regarding post-cancer treatment. For a majority of patients, nutrition during treatment and post-cancer diagnosis and treatment is an area they can control and change for their own health and well-being. However, Zhang[ ] published a study indicating that cancer survivors are usually motivated to improve their health but were found to have suboptimal diets. She examined the dietary intake of cancer survivors and individuals who had never had cancer. The researcher estimated the quality of the diets using the Health Eating Index, which is based on the United States government s Dietary Guidelines for Americans. The scores ranged from to , with indicating no adherence to which is total adherence. After adjusting for age, sex and ethnicity, Zhang found that the group who had not had cancer had an average index of . and the cancer survivors on average indexed . . It was found that cancer survivors in general from this population ate less fibre, more empty calories and more refined sugars and fats. In addition, they examined patients who had different types of cancer and found that those who had breast cancer had th...

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Type II Diabetes, Peripheral Neuropathy, and Gout

Ettinger

2017

Nutritional Pathophysiology of Obesity and Its Comorbidities

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Metformin With Either Histamine H2-Receptor Antagonists or Proton Pump Inhibitors: A Polypharmacy Recipe for Neuropathy via Vitamin B12 Depletion

Cited by 18 publications

References 52 publications

Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives

Integrative neuromuscular medicine: Neuropathy and neuropathic pain: Consider the alternatives

Cancer Treatment and Nutritional Deficiencies

Type II Diabetes, Peripheral Neuropathy, and Gout

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