Metformin Usage to Induce Ovulation in Women With Polycystic Ovary Syndrome: Meta-Analysis

Steimbach, Laiza Maria; Loução, Aline Dos Santos; Carraro, Christian; Tonin, Fernanda S.; Pontarolo, Roberto; Sanches, Andréia Cristina Conegero

doi:10.22159/ijpps.2016v8i11.9517

Cited by 2 publications

(2 citation statements)

References 15 publications

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“…She reported that using of oil extract of NS as percutaneous therapy enhances bone healing by enhancing different processes of cell migration and differentiation, extracellular matrix formation, and organization toward calcification. These results are consistent with other same reports [32][33][34][35].…”

Section: +2supporting

confidence: 94%

Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Osman

2017

Asian J Pharm Clin Res

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Osteoporosis is the most common reason for a broken bone among the elderly. Several experimental studies have been reported that Nigella sativa (NS) and/or its major component thymoquinone (TQ) have good effects on osteoporosis and bone healing. We conducted this systematic review to evaluate these relevant studies to prove whether NS and/or TQ has potential effect on osteoporosis and can stop pathogenesis of this disease or this matter still just a fiction. A search on published studies was done using databases including Scopus, PubMed, Google Scholar, Web of Science, and CINAHIL. Terms searched included "Nigella sativa, black seed, TQ, osteoporosis, bone healing." Initially, 213 articles were extracted. After reviewing their titles and abstracts, 124 articles (Medline, 43; Scopus, 67; EBSCO, 14) were retrieved for further evaluation. However, after excluding the clinical trial studies, human reviews, removal of abstracts and unrelated studies, seven studies were considered finally as eligible for our review. Finally, seven studies were considered eligible for our review. The total number of animals used was 220 (150 rats and 70 rabbits) from different experimental study. Based on the results of this systematic review, we conclude that NS or TQ extract therapy for osteoporosis cannot be recommended yet and these data will not suffice to exclude the beneficial effects of NS on bone turnover reliably. Therefore, more studies are required to explore the specific cellular and molecular targets of NS or TQ using animal osteoporosis models. Once the anti-osteoporotic effectiveness of NS or TQ will be established, human studies can be carried out.

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Section: +2supporting

confidence: 94%

Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Osman

2017

Asian J Pharm Clin Res

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“…Clomiphene resistance, which occurred in 25% of cases, or clomiphene failure often results in the use of more expensive treatment options for infertility [4]. Although adding metformin may show satisfactory results in women resistant to CC [5], the development of effective, simple, and safe treatments for infertility is an important public health goal [6].…”

Section: Introductionmentioning

confidence: 99%

Letrozole With or Without Gonadotropin as a First-Line Ovulation Induction in Anovulatory Infertile Women Due to Polycystic Ovary Syndrome

Alizzi

2018

Asian J Pharm Clin Res

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Objectives: The objective is to evaluate the clinical outcome of using letrozole alone or with gonadotropin as first-line ovulation induction in anovulatory infertile polycystic ovary women. Methods: A prospective single-arm study. 80 infertile polycystic ovarian syndrome (PCOS) women had been recruited between January and October 2017. Letrozole on day 2–3 of the cycle was given. The women are sorted into two groups according to the size of the dominant follicle on day 7 or 8, Group A (letrozole only group) and Group B (letrozole plus gonadotropin).Results: In our study, the overall pregnancy rate was (67.5%) and ovulation rate was 91.3%. The ovulation rate was significantly higher in Subgroup A than B (97.9% vs. 81.3%). Pregnancy rate was higher in Subgroup A (72.9% vs. 59.4%), but it was statistically not significant. The number of follicles was significantly higher in Subgroup B. Endometrial thickness, miscarriages, ovarian hyperstimulation syndrome, and multiple pregnancies were not statistically significant. Lower cycle number independently and significantly predict clinical pregnancy, while body mass index has a modest effect.Conclusions: Letrozole alone or in combination with gonadotropin as a first-line treatment in PCOS may be reasonable since this approach may improve the success rate and minimize the overall costs and risks.

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Metformin Usage to Induce Ovulation in Women With Polycystic Ovary Syndrome: Meta-Analysis

Cited by 2 publications

References 15 publications

Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Nigella Sativa Has Beneficial Effect on Osteoporosis and Bone Healing. Is It Fact or Fiction? A Systematic Review

Letrozole With or Without Gonadotropin as a First-Line Ovulation Induction in Anovulatory Infertile Women Due to Polycystic Ovary Syndrome

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