Metformin — today’s panacea?

Potempa, Magdalena; Jonczyk, Paweł; Szczerba, Kinga; Kandefer, Beata; Kajdaniuk, Dariusz

doi:10.5603/dk.2016.0020

Cited by 3 publications

(1 citation statement)

References 36 publications

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“…Autophagy can be triggered by metformin, which is an oral hypoglycaemic agent (De Santi et al 2019). It has been hypothesised that autophagy might play a role in cancer prevention through the elimination of damaged proteins and organelles, and metformin might have anti-cancer properties through different mechanisms, independent of its hypoglycaemic effect (Potempa et al 2016;Libby et al 2009;De Santi et al 2019). Noteworthy, calorie restriction (CR) triggers autophagy and leads to the purification of cells from their debris, which can enhance health and survival in model organisms.…”

Section: Atavistic Mechanisms Of Selfdestruction: Programmed Cell Deamentioning

confidence: 99%

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

Chmielewski

2020

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Ageing is one of the most complex and difficult problems for humans to face and for science to solve. Although human senescence was viewed as a passive and uncontrollable process of deterioration over time with little or no genetic regulation, the concept that ageing is caused by both genetic and environmental factors is now generally accepted, even though it remains difficult to distinguish between ageing sensu stricto and the effects of age-related diseases. Empirical data show that mechanisms of ageing are highly conserved during evolution. Moreover, it has been established that there are specific molecular ‘instructions’ for ageing, which suggests that a better understanding of the molecular biology of ageing will open new possibilities regarding future interventions. The complexity of ageing diminishes the possibility that any general theory will completely explain this metaphenomenon. Likewise, it is highly unlikely that any medication can stop or reverse human senescence. Nevertheless, ageing as a dynamic and malleable metaphenomenon can be modulated by a variety of influences. The concept of the shrinkage of the homeo-dynamic space with age, i.e. homeostenosis, is especially interesting and intriguing as it shows that novel therapeutic approaches and rational strategies can help delay the onset of the ageing-associated pathologies by enhancing the homeodynamic capabilities of the body. The aim of this article is to present current data from evolutionary and molecular gerontology and discuss them within the ambit of this review which is devoted to the dynamic, emergent and plastic nature of human ageing and implications for future interventions.

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Section: Atavistic Mechanisms Of Selfdestruction: Programmed Cell Deamentioning

confidence: 99%

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

Chmielewski

2020

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Is metformin a geroprotector? A peek into the current clinical and experimental data

Zajda

Huttunen

Sikora

et al. 2020

Mechanisms of Ageing and Development

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Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective

Torres

Nava

Galban

et al. 2020

CPD

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: Aging is a time-dependent inevitable process, in which cellular homeostasis is affected, which has an impact on tissue function. This represents a risk factor for the development of numerous non-transmissible diseases. In consequence, the scientific community continues to search for therapeutic measures capable of improving quality of life and delaying cellular aging. At the center of this research is metformin, a widely used drug in Type 2 Diabetes Mellitus treatment that has a reduced adverse effects profile. Furthermore, there is evidence that this drug has beneficial health effects that go beyond its anti-hyperglycemic properties. Among these effects, its geronto-protection capability stands out. There is growing evidence that points out to an increased life expectancy as well as quality of life in model organisms treated with metformin. Therefore, there is an abundance of research centered on elucidating the mechanism through which metformin has its anti-aging effects. Among these, the AMPK, mTORC1, SIRT1, FOXO, NF.kB, and DICER1 pathways can be mentioned. Furthermore, studies have highlighted the possibility of a role for gut microbiome in these processes. The next step is the design of clinical essays that have as a goal evaluating the efficacy and safety of metformin as an anti-aging drug in humans to create a paradigm in the medical horizon. The question being if metformin is in fact the new anti-aging therapy in humans?

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Metformin — today’s panacea?

Abstract: Metformin is still an immutable basic hypoglycemic drug used in pharmacotherapy of diabetes mellitus type 2. structurally it belongs to biguanide derivatives that was discovered in traditional herbalism. Galega

Cited by 3 publications

References 36 publications

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

The dynamic nature of ageing: novel findings, therapeutic avenues and medical interventions

Is metformin a geroprotector? A peek into the current clinical and experimental data

Anti-Aging Effect of Metformin: A Molecular and Therapeutical Perspective

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