Metformin overcomes metabolic reprogramming-induced resistance of skin squamous cell carcinoma to photodynamic therapy

Mascaraque, Marta; Gallego-Rentero, María; Nicolás-Morala, Jimena; Portillo-Esnaola, Mikel; Cuezva, José M.; González, Salvador; Gilaberte, Yolanda; Juarranz, Ángeles

doi:10.1016/j.molmet.2022.101496

Cited by 10 publications

(6 citation statements)

References 93 publications

(130 reference statements)

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“…Studies have shown that pretreatment with metformin can effectively prevent the metabolic reprogramming of SCC during PDT treatment and enhance the efficacy of PDT. 89 The pretreatment of 5-FU for 3 days could help ALA-PDT trigger more PpIX enrichment in SCCs and thus result in more cell death, whose mechanism may be related to changes in the expression of key enzymes, including upregulated coproporphyrinogen oxidase and downregulated ferrochelatase. 90 A three- to six-fold induction of p53 in 5-FU-pretreated tumors was also noted, which may play a certain role in the apoptosis induction and cell death.…”

Section: Resultsmentioning

confidence: 99%

Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

Sun¹,

Zhao²,

Lin³

et al. 2023

CCID

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Background Based on photochemical reactions through the combined use of light and photosensitizers, photodynamic therapy (PDT) is gaining popularity for the treatment of skin cancer. Various photosensitizers and treatment regimens are continuously being developed for enhancing the efficacy of PDT on skin cancer. Reviewing the development history of PDT on skin cancer, and summarizing its development direction and research status, is conducive to the further research. Methods To evaluate the research trends and map knowledge structure, all publications covering PDT on skin cancer were retrieved and extracted from Web of Science database. We applied VOSviewer and CiteSpace softwares to evaluate and visualize the countries, institutes, authors, keywords and research trends. Literature review was performed for the analysis of the research status of PDT on skin cancer. Results A total of 2662 publications were identified. The elements, mechanism, pros and cons, representative molecular photosensitizers, current challenges and research progress of PDT on skin cancer were reviewed and summarized. Conclusion This study provides a comprehensive display of the field of PDT on skin cancer, which will help researchers further explore the mechanism and application of PDT more effectively and intuitively.

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Section: Resultsmentioning

confidence: 99%

Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

Sun¹,

Zhao²,

Lin³

et al. 2023

CCID

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“…The complete response rate to PDT in the treatment of SCC is 82% ( 186 – 188 ). Due to poor tissue penetration by light and photosensitizer, PDT is more suitable for isolated, small, superficial SCCs ( 189 ). In addition, increased glycolysis and decreased oxidative phosphorylation, i.e.…”

Section: Review Of the Literaturementioning

confidence: 99%

The use of photodynamic therapy in medical practice

Aebisher,

Rogóż,

Myśliwiec

et al. 2024

Front. Oncol.

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Cancer therapy, especially for tumors near sensitive areas, demands precise treatment. This review explores photodynamic therapy (PDT), a method leveraging photosensitizers (PS), specific wavelength light, and oxygen to target cancer effectively. Recent advancements affirm PDT’s efficacy, utilizing ROS generation to induce cancer cell death. With a history spanning over decades, PDT’s dynamic evolution has expanded its application across dermatology, oncology, and dentistry. This review aims to dissect PDT’s principles, from its inception to contemporary medical applications, highlighting its role in modern cancer treatment strategies.

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“…[ 110,111 ] However, there is a way of energy metabolism in tumors that is distinct from that of normal cells. Otto Warburg observed for the first time in 1924 that cancer cells tend to undergo intense oxygen‐consuming glycolysis and produce lactic acid even in the case of sufficient oxygen, a phenomenon known as the “Warburg effect”/“aerobic glycolysis.” [ 32,102,108,112,113 ] Aerobic glycolysis is a critical link in the occurrence and development of cancer. [ 114 ] High‐throughput glycolysis can fast supply energy for cancer cells and produce a variety of critical intermediate metabolites, laying a foundation for other metabolic pathways and the synthesis of biological macromolecules.…”

Section: Intervention Of Tumor Cell Metabolismmentioning

confidence: 99%

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

Yu,

Li,

Wang

et al. 2023

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Photodynamic therapy (PDT) has recently been considered a potential tumor therapy due to its time‐space specificity and non‐invasive advantages. PDT can not only directly kill tumor cells by using cytotoxic reactive oxygen species but also induce an anti‐tumor immune response by causing immunogenic cell death of tumor cells. Although it exhibits a promising prospect in treating tumors, there are still many problems to be solved in its practical application. Tumor hypoxia and immunosuppressive microenvironment seriously affect the efficacy of PDT. The hypoxic and immunosuppressive microenvironment is mainly due to the abnormal vascular matrix around the tumor, its abnormal metabolism, and the influence of various immunosuppressive‐related cells and their expressed molecules. Thus, reprogramming the tumor microenvironment (TME) is of great significance for rejuvenating PDT. This article reviews the latest strategies for rejuvenating PDT, from regulating tumor vascular matrix, interfering with tumor cell metabolism, and reprogramming immunosuppressive related cells and factors to reverse tumor hypoxia and immunosuppressive microenvironment. These strategies provide valuable information for a better understanding of the significance of TME in PDT and also guide the development of the next‐generation multifunctional nanoplatforms for PDT.

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Metformin overcomes metabolic reprogramming-induced resistance of skin squamous cell carcinoma to photodynamic therapy

Cited by 10 publications

References 93 publications

Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

Global Trends and Research Progress of Photodynamic Therapy in Skin Cancer: A Bibliometric Analysis and Literature Review

The use of photodynamic therapy in medical practice

Recent Advances in Reprogramming Strategy of Tumor Microenvironment for Rejuvenating Photosensitizers‐Mediated Photodynamic Therapy

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