Metformin-Loaded Polymer-Based Microbubbles/Nanoparticles Generated for the Treatment of Type 2 Diabetes Mellitus

Cesur, Sümeyye; Çam, Muhammet Emin; Sayın, Fatih Serdar; Su, Sena; Harker, A. H.; Edirisinghe, Mohan; Gündüz, Oğuzhan

doi:10.1021/acs.langmuir.1c00587

Cited by 36 publications

(30 citation statements)

References 63 publications

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“…RS was successfully loaded into particles within the optimized system parameters. There was no formation of crystals or clumps resulting from the loading and consequent dispersion of the active molecule as reported in literature with different studies [ 38 , 56 , 57 ].…”

Section: Resultssupporting

confidence: 76%

“…A variety of techniques have been employed to produce nanoscale polymeric particles. Spray drying, coacervation/precipitation, solvent extraction/evaporation, ionic gelation are some examples for conventional methods [ 37 , 38 ]. Besides these nanoparticle fabrication techniques, the EHDA process, also called electrospray technique, is a convenient method due to its properties like the cost-effectiveness and short duration of operation, one-step easy production process and production of near-uniform sized particles by easily tailoring system parameters such as voltage, flow rate, collector distance and polymer concentration [ 9 , 33 , 39 , 40 , 41 ].…”

Section: Introductionmentioning

confidence: 99%

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Resveratrol-Loaded Levan Nanoparticles Produced by Electrohydrodynamic Atomization Technique

et al. 2021

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Considering the significant advances in nanostructured systems in various biomedical applications and the escalating need for levan-based nanoparticles as delivery systems, this study aimed to fabricate levan nanoparticles by the electrohydrodynamic atomization (EHDA) technique. The hydrolyzed derivative of levan polysaccharide from Halomonas smyrnensis halophilic bacteria, hydrolyzed Halomonas levan (hHL), was used. Nanoparticles were obtained by optimizing the EHDA parameters and then they were characterized in terms of morphology, molecular interactions, drug release and cell culture studies. The optimized hHL and resveratrol (RS)-loaded hHL nanoparticles were monodisperse and had smooth surfaces. The particle diameter size of hHL nanoparticles was 82.06 ± 15.33 nm. Additionally, release of RS from the fabricated hHL nanoparticles at different pH conditions were found to follow the first-order release model and hHL with higher RS loading showed a more gradual release. In vitro biocompatibility assay with human dermal fibroblast cell lines was performed and cell behavior on coated surfaces was observed. Nanoparticles were found to be safe for healthy cells. Consequently, the fabricated hHL-based nanoparticle system may have potential use in drug delivery systems for wound healing and tissue engineering applications and surfaces could be coated with these electrosprayed particles to improve cellular interaction.

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Section: Resultssupporting

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Resveratrol-Loaded Levan Nanoparticles Produced by Electrohydrodynamic Atomization Technique

et al. 2021

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“…Metformin has no serious side effects, but drug overdose can cause lactic acidosis, especially in people with certain medical conditions [7]. Several drug delivery systems have been designed to increase the bioavailability and effect of orally administered antidiabetic drugs [8].…”

Section: Introductionmentioning

confidence: 99%

Controlled release of metformin-loaded SA/PEG scaffolds produced by 3d-printing technology

USTUNDAG¹

2023

Sigma J Eng Nat Sci - Sigma Müh Fen Bil Derg

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Type 2 diabetes mellitus (T2DM) is a long-term metabolic disease that is commonly characterized by insulin deficiency or resistance, and prevalence has been increasing gradually all over the world. The aim of this study is to produce Metformin-loaded 3D printed scaffolds for an alternative drug delivery application in the treatment of Type 2 DM with two different biopolymers. Sodium Alginate (SA)/Polyethylene glycol (PEG) scaffolds loaded with varying concentrations of Metformin (0.5 and 2 wt.%) were prepared by adding 9 wt.% of SA to 3 wt.% of PEG. The physical analyses of the solutions were examined after the production process, and as a result, no significant changes were observed in the viscosity, density, and surface tension of the solutions with the addition of Metformin. Morphological (SEM), molecular interaction (FTIR), thermal analysis (DSC), tensile strength analyses were done. SEM images and histograms showed that the desired pore structure was obtained in the scaffolds produced by the 3D printing method, and the average pore sizes were 236.14±18.999, 255.28±14.168, and 318.83±13.038 μm for SA/PEG, 0.5% and 2% Metformin-loaded scaffolds, respectively. A drug release test was performed by UV spectroscopy. Metformin from both 0.5% and 2% scaffolds showed a burst release in 30 minutes because of the high solubility of SA and PEG in water. More than 97% of the drug was released from both scaffolds. However, they displayed sustained release up to 24 hours. Therefore, Metformin-loaded 3D-printed scaffolds have promising potential for the treatment of T2DM as they are an alternative to the oral administration of the drug.

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“…PVA is also a well-known noble metal particle stabilizer/capping agent, and thus, there is a high interest in developing PVA-based nanostructures [ 9 ]. PVA is a biopolymer that has excellent biocompatibility, biodegradability, fiber formability, chemical resistance, moisture absorbency, and swelling properties, making it perfect for use in wound healing [ 10 , 11 ]. Because they are non-toxic, biocompatible, and oxygen permeable, PVA nanofibers can absorb wound exudate and aid in tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

Manufacturing of Zinc Oxide Nanoparticle (ZnO NP)-Loaded Polyvinyl Alcohol (PVA) Nanostructured Mats Using Ginger Extract for Tissue Engineering Applications

et al. 2022

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In this research, as an alternative to chemical and physical methods, environmentally and cost-effective antimicrobial zinc oxide nanoparticles (ZnO NP) were produced by the green synthesis method. The current study focuses on the production of ZnO NP starting from adequate precursor and Zingiber officinale aqueous root extracts (ginger). The produced ZnO NP was loaded into electrospun nanofibers at different concentrations for various tissue engineering applications such as wound dressings. The produced ZnO NPs and ZnO NP-loaded nanofibers were examined by Scanning Electron Microscopy (SEM) for morphological assessments and Fourier-transform infrared spectrum (FT-IR) for chemical assessments. The disc diffusion method was used to test the antimicrobial activity of ZnO NP and ZnO NP-loaded nanofibers against three representatives strains, Escherichia coli (Gram-negative bacteria), Staphylococcus aureus (Gram-positive bacteria), and Candida albicans (fungi) microorganisms. The strength and stretching of the produced fibers were assessed using tensile tests. Since water absorption and weight loss behaviors are very important in tissue engineering applications, swelling and degradation analyses were applied to the produced nanofibers. Finally, the MTT test was applied to analyze biocompatibility. According to the findings, ZnO NP-loaded nanofibers were successfully synthesized using a green precipitation approach and can be employed in tissue engineering applications such as wound dressing.

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Metformin-Loaded Polymer-Based Microbubbles/Nanoparticles Generated for the Treatment of Type 2 Diabetes Mellitus

Cited by 36 publications

References 63 publications

Resveratrol-Loaded Levan Nanoparticles Produced by Electrohydrodynamic Atomization Technique

Resveratrol-Loaded Levan Nanoparticles Produced by Electrohydrodynamic Atomization Technique

Controlled release of metformin-loaded SA/PEG scaffolds produced by 3d-printing technology

Manufacturing of Zinc Oxide Nanoparticle (ZnO NP)-Loaded Polyvinyl Alcohol (PVA) Nanostructured Mats Using Ginger Extract for Tissue Engineering Applications

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