Metformin inhibits inflammatory angiogenesis in a murine sponge model

Xavier, D.O.; Amaral, Luciana S; Gomes, Maria Aparecida; Rocha, Monaliza Angela; Campos, Paula R.; Cota, Bianca Della Croce Vieira; Tafuri, Luciene S A; Paiva, Alexander; Silva, J.H.; Andrade, Sílvia Passos; Belo, Andrezza V.

doi:10.1016/j.biopha.2009.08.004

Cited by 60 publications

(45 citation statements)

References 32 publications

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“…The effects of various anti-inflammatory/antiangiogenic compounds have been determined using this implantation technique [58]. Angiogenesis describes the formation of new vessels develop by sprouting from pre-existing vessels, splitting of parent vessels into daughter vessels, or in situ differentiation from primitive mesenchymal cells and circulating endothelial progenitor cells [59]. Angiogenesis is a complex process which involves basement membrane degradation by metalloproteinases, endothelial cell migration, endothelial cell proliferation and basement membrane synthesis by endothelial cells of the newly formed capillaries [60,61].…”

Section: Inhibition Of Inflammatory Angiogenesismentioning

confidence: 99%

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Pinto

Cunha

Oréfice

et al. 2012

J Mater Sci: Mater Med

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The purpose of this study was to develop triamcinolone acetonide-loaded polyurethane implants (TA PU implants) for the local treatment of different pathologies including arthritis, ocular and neuroinflammatory disorders. The TA PU implants were characterized by FTIR, SAXS and WAXS. The in vitro and in vivo release of TA from the PU implants was evaluated. The efficacy of TA PU implants in suppressing inflammatory-angiogenesis in a murine sponge model was demonstrated. FTIR results revealed no chemical interactions between polymer and drug. SAXS results indicated that the incorporation of the drug did not disturb the polymer morphology. WAXS showed that the crystalline nature of the TA was preserved after incorporation into the PU. The TA released from the PU implants efficiently inhibited the inflammatory-angiogenesis induced by sponge discs in an experimental animal model. Finally, TA PU implants could be used as local drug delivery systems because of their controlled delivery of TA.

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Section: Inhibition Of Inflammatory Angiogenesismentioning

confidence: 99%

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Pinto

Cunha

Oréfice

et al. 2012

J Mater Sci: Mater Med

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“…Some studies suggest that metformin may also target the inflammatory component present in the microenvironment of most neoplastic tissues, leading to tumour reduction. In addition, inhibition of neoplastic angiogenesis by metformin might also participate in the reduction of tumour growth [20] [21]. Another study on breast cancer states that metformin has an ability to selectively kill cancer stem cells and to function synergistically with chemotherapeutic agents to block both cancer stem cells and non-stem transformed cells [22].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Clear Cell Carcinoma of the Endometrium

Kankava¹,

Baidoshvili²,

Schutter³

et al. 2016

JCT

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This report documents a rare case of complete spontaneous regression of clear cell carcinoma of the endometrium. An elderly woman with paranoid schizophrenia was admitted to the hospital because of vaginal bleeding. Diagnostic curetting and biopsy were performed and she was diagnosed with clear cell carcinoma of endometrium. Anti-tumour therapy was not possible because of her poor psychiatric status. 13 months later the woman died of a natural cause and at autopsy the endometrial tumour could no longer be identified. Myocardial infarction, aggravated by poor functional status of organism due to sepsis, was concluded to be the cause of death.

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“…Por otro lado, y de forma no dependiente de insulina, la activación de la AMPK, como principal determinante en la vía anticancerígena, produce la inhibición de la señalización Phosphatidylinositol-4,5-bisphosphate 3-kinase, AKT y R Mammalian Target of Rapamycin, fundamental en la patogenia de la carcinogénesis [115][116][117] . Adicional a los efectos antineoplásicos, también han sido reportadas propiedades anti-metastásicas, al inhibir la angiogénesis, mecanismo pilar del fenómeno de metástasis, al reducir los niveles del factor de crecimiento endotelial vascular tipo 1, Inhibidor Plasmático del Factor activador Plasminógeno 1 (PAI-1) , Metalopreinasas de Matriz tipo 2 y tipo 9 [118][119][120][121] , así como el bloqueo del potencial invasivo celular, tras la inversión de la transición mesénquima-epitelio mediado por la inhibición del TGFβ 122,123 .…”

Section: El Estudio the Glycometabolic Intervention As Adjunct To Priunclassified

Metformina: más allá del control glucémico

Morantes-Caballero

Londoño-Zapata

Rubio-Rivera

et al. 2017

revmed

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RESUMENIntroducción: la metformina es una biguanida que disminuye gluconeogénesis e incrementa la recaptación de glucosa en los músculos, sin embargo, más allá del glucémico se han documentado beneficios adicionales como la disminución de complicaciones crónicas derivadas de la hiperglucemia, entre ellas las cardiovasculares y del síndrome metabólico per se. Objetivo: identificar los efectos de la metformina diferentes al control control glucémico en población con diabetes mellitus, con el fin de contribuir a difundir el conocimiento. Materiales y método: tres revisores independientes realizaron la búsqueda en distintas bases de datos entre ellas Pubmed y ScienceDirect, utilizando los términos Metfomin AND Cardiovascular disease AND inflamatory response AND Hyperlipidemia, Biguanides, Diabetes Mellitus, Diabetes complications, Obesity, Vascular diseases AND Cancer; y Metfomina y enfermedad cardiovascular, metformina y cáncer se seleccionaron los artículos desde el año 2010, encontrando 13 828 artículos, de los cuales se incluyeron 144. Conclusión: más allá del control glucémico, la metformina, modifica la "memoria metabólica", reduce mediadores inflamatorios y el grosor de pared arterial, disminuye factores trombóticos y reduce la prevalencia de falla cardiaca logrando impactar la morbimortalidad y mediante cambios moleculares o genéticos, tiene potencial uso como anticancerígeno. El clínico debe conocer estos efectos para favorecer su pronto inicio en los casos indicados. Metformin: beyond the glycemic targetABSTRACT Introduction: the metformin is a biguanide which main action is to decrease hepatic glucose output, primarily by decreasing gluconeogenesis, and increase glucose uptake by muscles. However, beyond the glycemic target, additional benefits have been documented like a decrease in chronic complications to hyperglycemia, including cardiovascular comorbility and metabolic syndrome. Objetive: to identify effects of metformin other than glycemic control in patients with diabetes mellitus in order to help disseminate knowledge. Materials and methods: three independent reviewers searched in different databases of PubMed and ScienceDirect using the DeCS and MeSH terms: Metfomin AND Cardiovascular disease AND inflamatory response AND Hyperlipidemia, Biguanides, Diabetes Mellitus, Diabetes complications,Obesity, Vascular diseases AND Cancer, selecting the items since 2010 year and prior to warrant mention. Search based publications that were considered most relevant and, additionally, a manual search of the referenced articles in publications retrieved in the initial search was conducted, 13 828 articles were found but 144 were included finally. Conclusion: beyond glycemic control, Metformin, modifies the "metabolic memory", reduces inflammatory mediators and thickness of arterial wall, decreases thrombotic factors and reduces the prevalence of heart failure making an impact morbidity and mortality and because of molecular or genetic changes, it has potential use as anticarcinogenic. The physicians should know...

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Metformin inhibits inflammatory angiogenesis in a murine sponge model

Cited by 60 publications

References 32 publications

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis

Spontaneous Regression of Clear Cell Carcinoma of the Endometrium

Metformina: más allá del control glucémico

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