2018
DOI: 10.1016/j.jbior.2018.02.002
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Metformin influences drug sensitivity in pancreatic cancer cells

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive, highly metastatic malignancy and accounts for 85% of pancreatic cancers. PDAC patients have poor prognosis with a five-year survival of only 5-10% after diagnosis and treatment. Pancreatic cancer has been associated with type II diabetes as the frequency of recently diagnosed diabetics that develop pancreatic cancer within a 10-year period of initial diagnosis of diabetes in increased in comparison to non-diabetic patients. Metformin is a very frequentl… Show more

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Cited by 46 publications
(35 citation statements)
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“…The PI3K/PTEN/AKT/mTORC1/GSK-3 signaling pathway is often regulated by nutraceuticals such as BBR. This pathway plays critical roles in: diabetes, cardiovascular diseases, inflammation, neuropathology, obesity, as well as cancer (McCubrey et al, 2017;Candido et al, 2018;Duda et al, 2018;McCubrey et al, 2018).…”
Section: Bbr Effects On Signaling Pathways Implicated In Drug Resistancementioning
confidence: 99%
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“…The PI3K/PTEN/AKT/mTORC1/GSK-3 signaling pathway is often regulated by nutraceuticals such as BBR. This pathway plays critical roles in: diabetes, cardiovascular diseases, inflammation, neuropathology, obesity, as well as cancer (McCubrey et al, 2017;Candido et al, 2018;Duda et al, 2018;McCubrey et al, 2018).…”
Section: Bbr Effects On Signaling Pathways Implicated In Drug Resistancementioning
confidence: 99%
“…Metformin (N,N-dimethylimidodicarbonimidic diamide) is a type II diabetes drug which also has effects on cancer (Lonardo et al, 2013;Candido et al, 2018). Metformin mainly blocks hepatic gluconeogenesis.…”
Section: Introductionmentioning
confidence: 99%
“…The development of PDAC is complex and includes both environmental, as well as, genetic risk factors (Klein, 2012). We have recently summarized the risk and genetic factors associated with development of pancreatic cancer (Abrams et al, 2018(Abrams et al, , 2019Candido et al, 2018). Some of the risk factors for PDAC development in the USA are race and gender based, as well as, diabetes and obesity.…”
Section: Pancreatic Cancer: a Devastating Cancer With Few Effective Tmentioning
confidence: 99%
“…Cells were cultured in medium containing 5% fetal bovine serum (FBS) (Atlanta Biologicals, Atlanta, GA, USA) as described in (Abrams et al, 2017(Abrams et al, , 2018(Abrams et al, , 2019Steelman et al, 2017;Candido et al, 2018). Tissue culture medium (Dulbecco's modified Eagles medium, DMEM), antibiotics containing L-glutamine and trypsin were obtained from Invitrogen (Carlsbad, CA, USA).…”
Section: Cell Lines and Tissue Culturementioning
confidence: 99%
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