Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome

Glueck, Charles J.; Wang, Ping; Fontaine, R; Tracy, Trent; Sieve-Smith, Luann

doi:10.1016/s0026-0495(99)90113-0

Cited by 205 publications

(110 citation statements)

References 23 publications

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“…As previously, we observed only a small improvement. Other studies dealing with PCOS and finding a significant decrease in fasting insulin levels almost invariably involved women with an average BMI between 27 and 36 kg/m 2 (10,16,18,19,27). Moreover, the degree of hyperinsulinaemia in these studies was greater than in our patients.…”

Section: ) Although Not With Those Obtained By Others (12± 15)contrasting

confidence: 43%

The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome

et al. 2001

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Objective: To evaluate adrenal and ovarian steroidogenesis before and after long-term treatment with metformin in women with polycystic ovary syndrome (PCOS). Design and Methods: Twenty-four women with PCOS were evaluated before and after treatment (27^4 weeks) with metformin (1000 mg/day) using adrenocorticotrophin (ACTH), GnRH analogue and oral glucose tolerance (oGTT) tests. For statistical evaluation, ANOVA and Wilcoxon's test were used. Results: In 58% of the women a significant improvement in menstrual cyclicity was observed. No significant change in basal steroid levels was found. After ACTH stimulation, a significant decrease in the activity of 3b-hydroxysteroid dehydrogenase in C 21 steroids P , 0X05 and in 17b-hydroxysteroid dehydrogenase P , 0X01 was observed, as was an increase in the activity of C17,20-lyase in the D 4 pathway P , 0X01X A significant growth in the dehydroepiandrosterone (DHEA)/DHEA-sulfate ratio P , 0X05 was detected. With regard to ovarian steroidogenesis, a significant decrease in the stimulated levels of testosterone P , 0X05Y index of free testosterone P , 0X01Y LH P , 0X05 and oestradiol P , 0X01Y and an increase in the levels of 17-hydroxypregnenolone P , 0X05 were detected. In the indices of ovarian enzyme activities, we observed a significant decrease in 3b-hydroxysteroid dehydrogenase in C 21 steroids P , 0X01Y in C17,20-lyase in the D5 pathway P , 0X01Y in 17b-hydroxysteroid dehydrogenase P , 0X05 and in aromatase. In glucose metabolism, a tendency towards reduction in the homeostasis model assessment (HOMA)-R (for insulin resistance) and HOMA-F (for b cell function) was detected. In addition, an increase in the levels of C peptide during oGTT was observed P , 0X01X Conclusions: Long-term metformin treatment reduced various steroid enzymatic activities both in the ovary and the adrenal glands, without apparent changes in basal steroid levels and in insulin sensitivity.

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Section: ) Although Not With Those Obtained By Others (12± 15)contrasting

confidence: 43%

The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome

et al. 2001

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“…14,15 It also improved menstrual abnormalities in women with PCOS, which was similar to other studies. 16,17 Metformin may reduce the severity of AN, In the present study we confirmed that six months of Met-SR therapy had enough to treat AN in PCOS women.…”

Section: Discussionsupporting

confidence: 82%

Effect of sustained released metformin therapy on phenotypic and biochemical markers of insulin resistance in polycystic ovary syndrome in South Indian women

Kumar

Seshadri

Pandurangi

2016

Int J Reprod Contracept Obstet Gynecol

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“…These are found helpful in reducing the risk of diabetes and the metabolic syndrome. Also it is successful in improving fertility outcomes in PCOS [9,10]. However, the literature on effective diet and exercise programmes for PCOS has been sparse [13].…”

Section: Metforminmentioning

confidence: 99%

“…Hyperinsulinaemia due to insulin resistance occurs in approximately 80% of PCOS women central obesity & 30%-40% of lean PCOS women. Measurement of the fasting insulin concentration [10] is an easy marker to obtain, and values equal to 20 or higher indicate the presence of insulin resistance. Hyperinsulinemia is the main causative factor in PCOD women both obese &lean (4,5) & cause hyperandrogenism.…”

Section: Introductionmentioning

confidence: 99%

Effect of metformin & myoinositol & life style modification in patients of polycystic ovarian disease (PCOD)

Awalekar¹,

Awalekar²,

Jadhav³

et al. 2015

Int Jour of Biomed Res

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Metformin-induced resumption of normal menses in 39 of 43 (91%) previously amenorrheic women with the polycystic ovary syndrome

Cited by 205 publications

References 23 publications

The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome

The effects of long-term metformin treatment on adrenal and ovarian steroidogenesis in women with polycystic ovary syndrome

Effect of sustained released metformin therapy on phenotypic and biochemical markers of insulin resistance in polycystic ovary syndrome in South Indian women

Effect of metformin & myoinositol & life style modification in patients of polycystic ovarian disease (PCOD)

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