Metformin-induced PCSK9 inhibition further decreases LDL-C following statin treatment in non-diabetic patients with coronary artery disease and hyperlipoproteinemia(a)
Abstract:Purpose: Previous studies have revealed that metformin can downregulate PCSK9 expression in vitro, which provides a strong rationale for a possible beneficial impact on lowering atherogenic lipoprotein particles by metformin combination therapy. We aimed to investigate whether adding metformin could counteract the adverse effect of statins on PCSK9 and thus further improve lipid profiles in non-diabetic patients with CAD and hyperlipoproteinemia(a).
Methods: This was an open-label, placebo-controlled, randomiz… Show more
Set email alert for when this publication receives citations?
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.