Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction

Audia, Pat; Feinfeld, Donald A.; Dubrow, Alan; Winchester, James F.

doi:10.1080/15563650701355314

Cited by 30 publications

(17 citation statements)

References 19 publications

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“…Other intercurrent conditions included gastrointestinal bleeding (20%), liver disease (20%), and pancreatitis (10%). Furthermore, most patients with type 2 diabetes mellitus are on a number of other therapeutic agents (such as angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, nonsteroidal anti-inflammatory drugs, and diuretics) that may exacerbate renal function impairment in the state of renal hypoperfusion [14,15]. Precautions should also be considered when these conditions are anticipated.…”

Section: Discussionmentioning

confidence: 98%

Impact of acute kidney injury on metformin-associated lactic acidosis

Wen

2009

Int Urol Nephrol

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Section: Discussionmentioning

confidence: 98%

Impact of acute kidney injury on metformin-associated lactic acidosis

Wen

2009

Int Urol Nephrol

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“…In the literature, only a handful of case reports have been published concerning a possible link between metformin overdosage and acute pancreatitis [24][25][26][27] . To our knowledge, pancreatitis caused by therapeutic doses of metformin in the absence of impaired renal function has never been reported.…”

Section: Discussionmentioning

confidence: 99%

Metformin-Associated Lactic Acidosis in Chinese Patients with Type II Diabetes

Yeung¹,

Chung

Fong³

et al. 2011

Pharmacology

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Metformin is a widely used antidiabetic agent that is generally considered safe. However, metformin-associated lactic acidosis (MALA), though not common, occurs from time to time and results in significantly high mortality. A series of 23 MALA cases in a local major hospital in Hong Kong is reported in this article to demonstrate the epidemiological data, risk factors, clinical features as well as the clinical outcomes for better understanding of this disease entity. It is the first MALA case series in which plasma metformin levels were assessed. However, the results show that plasma metformin levels in MALA bear no diagnostic and prognostic values. Risk factors of mortality were identified as shock and high plasma lactate levels. The majority of patients were found to have significantly raised creatinine versus a normal baseline value before the acute illness. Concomitant illnesses taking place alongside MALA were common. With a high utility rate of renal replacement therapy (82.6%) in the study group, the mortality rate was 30.4%.

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“…Great attention should always be given to those subjects undergoing treatment with different medications (136) or contrast media use (137) due to the risk of acute kidney dysfunction and lactic acidosis. In this regard, acute renal failure from contrast medium in patients taking metformin was described (138).…”

Section: Rare Side Effectsmentioning

confidence: 99%

Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review

et al. 2008

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Metformin is an insulin sensitizer widely used for the treatment of patients affected by type 2 diabetes mellitus. Because many women with polycystic ovary syndrome (PCOS) are insulin resistant, metformin was introduced in clinical practice to treat these patients also. Moreover, metformin's effect has other targets beside its insulin-sensitizing action. The present review was aimed at describing all evidence-based and potential uses of metformin in PCOS patients. In particular, we will analyze the uses of metformin not only for the treatment of all PCOS-related disturbances such as menstrual disorders, anovulatory infertility, increased abortion, or complicated pregnancy risk, hyperandrogenism, endometrial, metabolic and cardiovascular abnormalities, but also for the prevention of the syndrome. (Endocrine Reviews 30: 1-50, 2009)

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Metformin-induced lactic acidosis and acute pancreatitis precipitated by diuretic, celecoxib, and candesartan-associated acute kidney dysfunction

Cited by 30 publications

References 19 publications

Impact of acute kidney injury on metformin-associated lactic acidosis

Impact of acute kidney injury on metformin-associated lactic acidosis

Metformin-Associated Lactic Acidosis in Chinese Patients with Type II Diabetes

Evidence-Based and Potential Benefits of Metformin in the Polycystic Ovary Syndrome: A Comprehensive Review

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