Metformin hydrolase is a recently evolved nickel-dependent heteromeric ureohydrolase
M. Sinn,
L. Riede,
J. R. Fleming
et al.
Abstract:The anti-diabetic drug metformin is one of the most widely prescribed medicines in the world. Together with its degradation product guanylurea, it is a major pharmaceutical pollutant in wastewater treatment plants and surface waters. An operon comprising two genes of the ureohydrolase family in Pseudomonas and Aminobacter species has recently been implicated in metformin degradation. However, the corresponding proteins have not been characterized. Here we show that these genes encode a Ni2+-dependent enzyme th… Show more
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