Metformin: From Diabetes to Cancer —Unveiling Molecular Mechanisms and Therapeutic Strategies
Emilia Amengual-Cladera,
Pere Miquel Morla-Barcelo,
Andrea Morán-Costoya
et al.
Abstract:Metformin, a widely used anti-diabetic drug, has garnered attention for its potential in cancer management, particularly in breast and colorectal cancer. It is established that metformin reduces mitochondrial respiration, but its specific molecular targets within mitochondria vary. Proposed mechanisms include inhibiting mitochondrial respiratory chain Complex I and/or Complex IV, and mitochondrial glycerophosphate dehydrogenase, among others. These actions lead to cellular energy deficits, redox state changes,… Show more
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