Cyclophosphamide, ifosfamide, methotrexate, 5-fluorouracil, taxol, vinca alkaloids and platinum compounds are commonly used as chemotherapeutic agents on cancer. Cytostatic compounds have a generally polar structure and have been detected in hospital wastewaters, the influents and effluents of WWTPs and surface waters [Besse et al. 2012, Zhang et al. 2013, Yu-Chen Lin et al. 2014]. According to a review by Kosjek and Heath [Kosjek and Heath 2011], last studies have been primarily focused on hospital effluents, and only a few of them have focused on environmental samples and their fate. Most cytostatic compounds are not likely to undergo biodegradation or volatilization processes, and a limited number of studies has reported their degradation by sunlight photolysis [Kosjek and Heath 2011]. Cyclophosphamide (CP)-a cytotoxic agent that alkylates DNA, has a wide spectrum of clinical uses in the chemotherapy treatment of many neoplastic diseases. The acute toxicities of CP