Metformin Causes Hepato-renal Dysfunctions in Obese Male Rats

El‐Naggar, Sabry A.; Elwan, Mona; Basyouny, Mohamed Abo Elftouh; Elshennawy, Ehab Othman; El-Said, Karim Samy

doi:10.1590/1678-4324-2021210188

Cited by 2 publications

(1 citation statement)

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“…2, Issue (1): Pages 18-35 excess lipids in the circulation can harm the heart by accumulating hazardous metabolic byproducts such as reactive oxygen species (ROS) and ceramides, which can cause myocyte malfunction and death by activating signaling pathways (D'Oria et al, 2020). Obesity causes hematological, biochemical, and hepato-renal dysfunctions (El-Naggar et al, 2021). Nonadipocytes have a very limited capacity to store excess fat.…”

Section: Introductionmentioning

confidence: 99%

Ameliorative effect of celery seed oil against high-fat diet-induced lipotoxic heart disease in rats

Salem,

Mahmoud,

Shaker

et al. 2024

Biological and Biomedical Journal

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Obesity is a risk factor for heart disease. Persistent exposure to excess lipids in the circulation can harm the heart by accumulating hazardous metabolic byproducts such as reactive oxygen species and ceramides, which can cause myocyte malfunction and death by activating signaling pathways. Herbs are one of the most popular weight-loss alternative medicines in the world. Our study aimed to evaluate the possible effects of celery seed oil against high-fat diet-induced lipotoxicity of heart in rats. The study was conducted on 40 male Wistar rats that were classified into 2 groups. Group I (GpI) served as control. GpII was obese rats, subdivided into four subgroups (untreated, treated with orlistat drug, celery seed oil, and a combination of celery seed oil /orlistat drug. At the end of treatment, all rats were scarified, blood samples and heart tissues of the rats were collected. Celery seed oil showed ameliorative effect against high-fat diet-induced lipotoxic heart disease through multiple interrelated mechanisms including alleviation the histological changes, boosting the antioxidant status, improving lipid profile, and reducing fatty acid accumulation in cardiac tissue. The treatment with a combination of celery seed oil /orlistat drug showed the best effect. In conclusion, celery seed oil could be used for the protection against obesity alone or used as adjuvant with orlistat drugs to enhance their pharmacological effect against lipotoxic heart disease.

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Section: Introductionmentioning

confidence: 99%