Metformin administration modulates neurosteroids secretion in non-obese amenorrhoic patients with polycystic ovary syndrome

Abstract

Our data demonstrate that metformin administration modulates LH secretion as well as cortisol and allopregnanolone pulsatile release. In addition, the results demonstrate that adrenal and ovarian steroidogenic activity is greatly modulated by any change in insulin sensitivity.

Abnormal response of insulin to glucose loading and assessment of insulin resistance in non-obese patients with polycystic ovary syndrome

“…The findings are consistent with our data. Moreover, Genazzani and co-workers [36] reported that metformin administration decreased LH pulse amplitude, resulting in decreasing plasma androgen levels. Another recent report from the same group [37] showed that metformin administration was more effective in hyperinsulinemic hyperandrogenic PCOS patients.…”

“…Several recent studies [35][36][37] have indicated that metformin is effective in the improvement of the endocrine and metabolic abnormalities in patients with PCOS. Genazzani and co-workers [35] reported that the ratio of glucose to insulin was a good index of insulin sensitivity to evaluate the efficacy of metformin treatment in non-obese patients with PCOS.…”

Acupuncture for ovulation induction in polycystic ovary syndrome: a randomized controlled trial

“…Together with an exaggerated ovarian response, hypersecretion of LH drives excessive ovarian androgen production and causes anovulation (13). In PCOS, altered sex steroid production, metabolic dysfunction, and obesity all contribute to changes in LH secretion patterns and to anovulation (6,12,29,30).…”

“…Together with an exaggerated ovarian response, hypersecretion of LH drives excessive ovarian androgen production and causes anovulation (13). In PCOS, altered sex steroid production, metabolic dysfunction, and obesity all contribute to changes in LH secretion patterns and to anovulation (6,12,29,30).Clomiphene citrate, exogenous gonadotropin therapy, and laparoscopic ovarian drilling are commonly used to induce ovulation in women with PCOS (1). These treatments often have negative side effects, thus indicating the importance of evaluating alternative treatments such as acupuncture.…”

Reproductive neuroendocrine dysfunction in polycystic ovary syndrome: Insight from animal models

“…In women with PCOS, metformin reduces insulin and androgen levels and improves menstrual cyclicity (Palomba et al, 2009). It also has been shown in multiple studies to reduce the LH pulse amplitude in non-obese PCOS patients (Genazzani et al, 2006, 2004), suggesting a possible reduction in GnRH release. At baseline, PNA mice lacked measurable defects in insulin sensitivity, as measured by insulin tolerance testing, or in fed glucose or insulin levels, but tended toward elevated fasting glucose.…”