2008
DOI: 10.1176/appi.ajp.2007.07010079
|View full text |Cite
|
Sign up to set email alerts
|

Metformin Addition Attenuates Olanzapine-Induced Weight Gain in Drug-Naive First-Episode Schizophrenia Patients: A Double-Blind, Placebo-Controlled Study

Abstract: Metformin was effective and safe in attenuating olanzapine-induced weight gain and insulin resistance in drug-naive first-episode schizophrenia patients. Patients displayed good adherence to this type of preventive intervention.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
161
0
5

Year Published

2009
2009
2022
2022

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 193 publications
(168 citation statements)
references
References 40 publications
2
161
0
5
Order By: Relevance
“…Eleven double blind, randomized, controlled trials have examined Met in this role (Baptista et al 2006, Klein et al 2006, Arman et al 2008, Wu et al 2008a,b, 2012, Carrizo et al 2009, Chen et al 2013, Jarskog et al 2013. Of these, nine examined a surrogate measure of insulin sensitivity, the homeostasis model assessment of insulin resistance (HOMA-IR), with six demonstrating beneficial effects favoring Met (Wu et al 2008a,b, Carrizo et al 2009, Chen et al 2013, Jarskog et al 2013.…”
Section: Introductionmentioning
confidence: 99%
“…Eleven double blind, randomized, controlled trials have examined Met in this role (Baptista et al 2006, Klein et al 2006, Arman et al 2008, Wu et al 2008a,b, 2012, Carrizo et al 2009, Chen et al 2013, Jarskog et al 2013. Of these, nine examined a surrogate measure of insulin sensitivity, the homeostasis model assessment of insulin resistance (HOMA-IR), with six demonstrating beneficial effects favoring Met (Wu et al 2008a,b, Carrizo et al 2009, Chen et al 2013, Jarskog et al 2013.…”
Section: Introductionmentioning
confidence: 99%
“…Klein and colleagues, in their randomized, double-blind, placebo-controlled trial of metformin in children and adolescents taking atypical antipsychotics, found arrested weight gain, as well as improved insulin resistance (Klein et al 2006). Whereas Baptista and associates found that metformin did not prevent olanzapineinduced weight gain in a group of adult patients with schizophrenia (Baptista et al 2006), Wu and colleagues published two studies indicating that metformin, administered to a group of adult patients with schizophrenia on antipsychotics, including olanzapine, was effective in attenuating weight gain and improving insulin sensitivity (Wu et al 2008a;Wu et al 2008b). …”
Section: Introductionmentioning
confidence: 99%
“…Evidence indicates that metabolic profile of antipsychotics varies, therefore resulting in some having greater propensity than others to cause hyperglycemia [29,30]. However, clinicians need to consider the overall wellbeing of an individual and finely balance out improvements in mental health against physical health complications.…”
Section: Discussionmentioning
confidence: 99%