Meteorological factors affecting seroconversion of Akabane disease in sentinel calves in the subtropical Okinawa Islands of Japan

Hayama, Yoko; Yanase, Tohru; Suzuki, Moemi; Unten, Kazuhiko; Tomochi, Hisayuki; Kakehi, Mayu; Shono, Yukina; Yamamoto, Takehisa; Kobayashi, Sota; Murai, Kiyokazu; Tsutsui, Toshiyuki

doi:10.1007/s11250-017-1404-7

Cited by 6 publications

(3 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Simbuviruses are distributed worldwide (Table 1, Figure 1), and they persist in nature by alternately infecting mammalian hosts and Culicoides vectors. In endemic regions, Simbu serogroup viruses establish a pattern of cyclic circulation, with seasons of high virus appearance followed by periods of only sporadic detection [50,51,52,53,54,55], which is presumably related to the overall immunity in the host population and the abundance of Culicoides vectors.…”

Section: The Genus Orthobunyavirusmentioning

confidence: 99%

Culicoides Biting Midges—Underestimated Vectors for Arboviruses of Public Health and Veterinary Importance

Sick

Beer

Kampen

et al. 2019

Viruses

View full text Add to dashboard Cite

Culicoides biting midges, small hematophagous dipterans, are the demonstrated or putative vectors of multiple arboviruses of veterinary and public health importance. Despite its relevance in disease spread, the ceratopogonid genus Culicoides is still a largely neglected group of species, predominantly because the major human-affecting arboviruses are considered to be transmitted by mosquitoes. However, when a pathogen is detected in a certain vector species, a thorough search for further vectors often remains undone and, therefore, the relevant vector species may remain unknown. Furthermore, for many hematophagous arthropods, true vector competence is often merely suspected and not experimentally proven. Therefore, we aim to illuminate the general impact of Culicoides biting midges and to summarize the knowledge about biting midge-borne disease agents using the order Bunyavirales, the largest and most diverse group of RNA viruses, as an example. When considering only viruses evidentially transmitted by Culicoides midges, the Simbu serogroup (genus Orthobunyavirus) is presumably the most important group within the virus order. Its members are of great veterinary importance, as a variety of simbuviruses, e.g., the species Akabane orthobunyavirus or Schmallenberg orthobunyavirus, induces severe congenital infections in pregnant animals. The major zoonotic representative of this serogroup occurs in South and Central America and causes the so-called Oropouche fever, an acute febrile illness in humans.

show abstract

Section: The Genus Orthobunyavirusmentioning

confidence: 99%

Culicoides Biting Midges—Underestimated Vectors for Arboviruses of Public Health and Veterinary Importance

Sick

Beer

Kampen

et al. 2019

Viruses

View full text Add to dashboard Cite

show abstract

“…Simbuviruses infect predominantly ruminants and persist in nature by alternately infecting their insect vectors (Culicoides biting midges) and mammalian hosts (reviewed in [1]). In enzootic regions, Simbu serogroup viruses usually establish patterns of cyclic circulation, with seasons of high virus appearance followed by periods of only sporadic detections [13][14][15][16][17][18][19], which is most likely related to the overall immunity in the mammalian host population and the abundance of the insect vector. Co-circulation of several simbuviruses within a given area occurs frequently [2,[20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Antibodies against Selected Simbu Serogroup Viruses by a Glycoprotein Gc-Based Triplex ELISA

Wernike

Aebischer

Sick

et al. 2021

Veterinary Sciences

View full text Add to dashboard Cite

The Simbu serogroup of orthobunyaviruses includes several pathogens of veterinary importance, among them Schmallenberg virus (SBV), Akabane virus (AKAV) and Shuni virus (SHUV). They infect predominantly ruminants and induce severe congenital malformation. In adult animals, the intra vitam diagnostics by direct virus detection is limited to only a few days due to a short-lived viremia. For surveillance purposes the testing for specific antibodies is a superior approach. However, the serological differentiation is hampered by a considerable extent of cross-reactivity, as viruses were assigned into this serogroup based on antigenic relatedness. Here, we established a glycoprotein Gc-based triplex enzyme-linked immunosorbent assay (ELISA) for the detection and differentiation of antibodies against SBV, AKAV, and SHUV. A total of 477 negative samples of various ruminant species, 238 samples positive for SBV-antibodies, 36 positive for AKAV-antibodies and 53 SHUV antibody-positive samples were tested in comparison to neutralization tests. For the newly developed ELISA, overall diagnostic specificities of 84.56%, 94.68% and 89.39% and sensitivities of 89.08%, 69.44% and 84.91% were calculated for SBV, AKAV and SHUV, respectively, with only slight effects of serological cross-reactivity on the diagnostic specificity. Thus, this test system could be used for serological screening in suspected populations or as additional tool during outbreak investigations.

show abstract

“…The knowledge obtained from vector studies will contribute to increased accuracy of epidemiological analyses based on landscape and meteorological data. Risk assessments based on such analyses will enable the development of better surveillance and preventive measures for arbovirus infections which threaten the production of ruminant livestock, as suggested in earlier investigations (294,295).…”

Section: Research Gaps and Future Directionsmentioning

confidence: 99%

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

2020

Self Cite

View full text Add to dashboard Cite

Epizootic congenital abnormalities caused by Akabane, Aino, and Chuzan viruses have damaged the reproduction of domestic ruminants in East Asia for many years. In the past, large outbreaks of febrile illness related to bovine ephemeral fever and Ibaraki viruses severely affected the cattle industry in that region. In recent years, vaccines against these viruses have reduced the occurrence of diseases, although the viruses are still circulating and have occasionally caused sporadic and small-scaled epidemics. Over a long-term monitoring period, many arboviruses other than the above-mentioned viruses have been isolated from cattle and Culicoides biting midges in Japan. Several novel arboviruses that may infect ruminants (e.g., mosquito-and tick-borne arboviruses) were recently reported in mainland China based on extensive surveillance. It is noteworthy that some are suspected of being associated with cattle diseases. Malformed calves exposed to an intrauterine infection with orthobunyaviruses (e.g., Peaton and Shamonda viruses) have been observed. Epizootic hemorrhagic disease virus serotype 6 caused a sudden outbreak of hemorrhagic disease in cattle in Japan. Unfortunately, the pathogenicity of many other viruses in ruminants has been uncertain, although these viruses potentially affect livestock production. As global transportation grows, the risk of an accidental incursion of arboviruses is likely to increase in previously non-endemic areas. Global warming will also certainly affect the distribution and active period of vectors, and thus the range of virus spreads will expand to higher-latitude regions. To prevent anticipated damages to the livestock industry, the monitoring system for arboviral circulation and incursion should be strengthened; moreover, the sharing of information and preventive strategies will be essential in East Asia.

show abstract

Meteorological factors affecting seroconversion of Akabane disease in sentinel calves in the subtropical Okinawa Islands of Japan

Cited by 6 publications

References 25 publications

Culicoides Biting Midges—Underestimated Vectors for Arboviruses of Public Health and Veterinary Importance

Culicoides Biting Midges—Underestimated Vectors for Arboviruses of Public Health and Veterinary Importance

Differentiation of Antibodies against Selected Simbu Serogroup Viruses by a Glycoprotein Gc-Based Triplex ELISA

Endemic and Emerging Arboviruses in Domestic Ruminants in East Asia

Contact Info

Product

Resources

About