Metathesis of heteroatom-substituted olefins and alkynes: Current scope and limitations

Temporary Silicon‐Tethered Ring‐Closing Metathesis: Recent Advances in Methodology Development and Natural Product Synthesis

“…Enyne metathesis is an exceptional reaction because it provides a product containing the 1,3‐diene functionality, clearly distinctive from the functionality of starting material 12b,42. Moreover, the enyne metathesis can be used as a part of tandem process in the combination with ring‐closing metathesis or cross‐metathesis to construct multiple carbon–carbon bonds in the acyclic or cyclic framework 43.…”

Asymmetric catalysts for stereocontrolled olefin metathesis reactions

“…It should be noted at this point that selected substrates containing enolethers are capable of undergoing RCM (ring closing metathesis) employing achiral Ru-carbene complexes, but examples remain rare. 47 However, Scheme 22 highlights several important results for Mo-based systems. As can be seen therein, a synthetically useful scope of substrates can be introduced, whereby in these cases catalyst 8 has proven to be superior.…”

Synthesis of Natural Products Containing Medium‐Size Carbocycles by Ring‐Closing Alkene Metathesis

“…Compound 283, prepared from (S)-carvone, underwent Favorskii ring contraction and 284 was converted to enol ether 285. RCM of 285, using catalyst [Ru]-II (5 mol%) allows the formation of the bicyclic enol ether 286 in excellent yield (88%) [69,70]. The latter was then efficiently converted into the corresponding α-hydroxyketone 287 via asymmetric dihydroxylation.…”