Metatarsophalangeal joint pain in psoriatic arthritis: a cross-sectional study

Turner, Deborah E.; Hyslop, Elaine; Barn, Ruth; McInnes, Iain B.; Steultjens, Martijn; Woodburn, James

doi:10.1093/rheumatology/ket435

Cited by 24 publications

(20 citation statements)

References 15 publications

(12 reference statements)

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“…Apart from chondrocytes, other pathogenic factors, such as immune cells, cytokines, and hormones, lead to the pathogenic changes in the subchondral bone. Increasing evidence has demonstrated that synovium inflammation is involved in the progression of OA and associated with joint pain and dysfunction [ 41 , 42 ]. Various types of immune cells are infiltrated in the inflamed synovium of OA patients.…”

Section: Pathogenesis Of Cartilage Degeneration In Tmj Oamentioning

confidence: 99%

Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis

Cui

et al. 2017

Stem Cells International

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Temporomandibular joint osteoarthritis (TMJ OA) is a degenerative disease, characterized by progressive cartilage degradation, subchondral bone remodeling, synovitis, and chronic pain. Due to the limited self-healing capacity in condylar cartilage, traditional clinical treatments have limited symptom-modifying and structure-modifying effects to restore impaired cartilage as well as other TMJ tissues. In recent years, stem cell-based therapy has raised much attention as an alternative approach towards tissue repair and regeneration. Mesenchymal stem cells (MSCs), derived from the bone marrow, synovium, and even umbilical cord, play a role as seed cells for the cartilage regeneration of TMJ OA. MSCs possess multilineage differentiation potential, including chondrogenic differentiation as well as osteogenic differentiation. In addition, the trophic modulations of MSCs exert anti-inflammatory and immunomodulatory effects under aberrant conditions. Furthermore, MSCs combined with appropriate scaffolds can form cartilaginous or even osseous compartments to repair damaged tissue and impaired function of TMJ. In this review, we will briefly discuss the pathogenesis of cartilage degeneration in TMJ OA and emphasize the potential sources of MSCs and novel approaches for the cartilage regeneration of TMJ OA, particularly focusing on the MSC-based therapy and tissue engineering.

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Section: Pathogenesis Of Cartilage Degeneration In Tmj Oamentioning

confidence: 99%

Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis

Cui

et al. 2017

Stem Cells International

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“…Synovitis has been related not only to knee pain but also to knee joint function, using objective outcome measures of walking and stair-climbing times (72,73). These efforts have provided substantial evidence that synovitis is associated with major symptoms such as pain and degree of joint dysfunction, and may promote more rapid cartilage degeneration (69,74).…”

Section: Correlation Between Synovitis and Oamentioning

confidence: 99%

Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis

Wei

Bai

2016

Connective Tissue Research

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Osteoarthritis (OA), the most common form of degenerative joint disease, is linked to high morbidity. It is predicted to be the single greatest cause of disability in the general population by 2030. The development of disease-modifying therapy for OA currently face great obstacle mainly because the onset and development of the disease involve complex molecular mechanisms. In this review, we will comprehensively summarize biological and pathological mechanisms of three key aspects: degeneration of articular cartilage, synovial immunopathogenesis, and changes in subchondral bone. For each tissue, we will focus on the molecular receptors, cytokines, peptidases, related cell, and signal pathways. Agents that specifically block mechanisms involved in synovial inflammation, degeneration of articular cartilage, and subchondral bone remodeling can potentially be exploited to produce targeted therapy for OA. Such new comprehensive agents will benefit affected patients and bring exciting new hope for the treatment of OA.

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“…There is evidence on the link between PE and US to assess synovitis in small joints [ 14 ]. Turner et al investigated the US findings on the foot in PsA and found that higher body mass index (BMI), female sex, subluxation, and erosions were independent predictors of metatarsophalangeal (MTP) joint pain in PsA patients in addition to US-detected synovitis [ 15 ]. They clinically found 129 (32%) painful and 10 (3%) swollen MTP joints, while US-synovitis and PD positivity was less often, detected in 47 (14%), and 6 (2%) in MTP joints.…”

Section: Discussionmentioning

confidence: 99%

Accuracy of Physical Examination to Detect Synovial and Extra-Synovial Pathologies in Psoriatic Arthritis in Comparison to Ultrasonography

Gazel

Solmaz

Ayan

et al. 2020

JCM

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We aimed to explore the accuracy of physical examination (PE) to detect the synovial and extra-synovial pathologies in psoriatic arthritis (PsA) in comparison to ultrasonography (US). Twenty-nine PsA patients with hand pain were included in the study. A detailed PE of the hands was performed and US scans were performed for the joints, extensor and flexor tendons, and entheses of the second to fifth fingers of both hands. The agreement between PE and US findings was calculated. The strongest agreement for the joints was between “swollen joints” and power Doppler (PD) signals in the metacarpophalangeal (MCP) joints and grey scale synovitis in the proximal interphalangeal (PIP) joints. The agreement of tender entheses on PE and inflammation on US (hypoechogenicity, thickening, and/or PD signals) was poor for both extensor (Kappa = −0.027, Prevalence Adjusted and Bias Adjusted Kappa (PABAK) = 0.344) and flexor compartments (Kappa = 0.039, PABAK = 0.569). Similar to enthesitis, comparison of any PE and US findings showed a poor agreement at the extensor and flexor tendon regions (extensor: Kappa = 0.123, PABAK = 0.448, and flexor: Kappa = 0.171, PABAK = 0.431). Our study showed that there was a poor to fair agreement of PE and US findings of hands. US can add value when determining the source of pain in PsA in the small joints.

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Metatarsophalangeal joint pain in psoriatic arthritis: a cross-sectional study

Cited by 24 publications

References 15 publications

Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis

Mesenchymal Stem Cells for Cartilage Regeneration of TMJ Osteoarthritis

Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis

Accuracy of Physical Examination to Detect Synovial and Extra-Synovial Pathologies in Psoriatic Arthritis in Comparison to Ultrasonography

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