Metastatic vulvo-vaginal choriocarcinoma mimicking a Bartholin cyst and vulvar hematoma-two unusual presentations

Bhattacharyya, Sanjoy Kumar; Saha, Shyama Prasad; Mukherjee, Gourab; Samanta, Jaydeep

doi:10.5152/jtgga.2011.73

Cited by 8 publications

(8 citation statements)

References 5 publications

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“…1,2 Various unusual presentations of choriocarcinoma have been reported-purple skin lesions, vulvovaginal swelling, intestinal perforation, features of raised intra cranial pressure, cardiopulmonary manifestations. [1][2][3][4] Clinicians need to have an index of suspicion of choriocarcinoma in treating women with atypical features as early diagnosis and treatment with or without metastasis have excellent prognosis. 1,2 Initial high levels of serum β hcg, long duration from previous pregnancy, multiple tumor sites are high risk factors.…”

Section: Discussionmentioning

confidence: 99%

Choriocarcinoma with atypical presentations causing diagnostic dilemma

Paudyal

Rawal²,

Katuwal

et al. 2022

J. Kathmandu Med. Coll.

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Section: Discussionmentioning

confidence: 99%

Choriocarcinoma with atypical presentations causing diagnostic dilemma

Paudyal

Rawal²,

Katuwal

et al. 2022

J. Kathmandu Med. Coll.

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“…Two cases of metastatic choriocarcinoma that presented as vulvovaginal swelling were described in a report by Bhattacharyya et al Choriocarcinoma is a highly vascular tumor of the tropho-blast with immense potential for metastasis to the lung, liver, brain, or vulva. Thirty percent of such metastases are vulvovaginal [ 18 ] and their initial appearance often is misleading. The sole clinical presentation of onset of vulvovaginal swelling can confuse clinicians.…”

Section: Discussionmentioning

confidence: 99%

“…Both cases that have previously been described were initially misdiagnosed. Unresponsiveness to treatment led clinicians to perform further examination [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Case of Early Transformation of Gestational Trophoblastic Neoplasia Following Molar Pregnancy

et al. 2021

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Patient: Female, 19-year-old Final Diagnosis: Gestational thropoblastic neoplasia Symptoms: Bleeding Medication:— Clinical Procedure: Curettage Specialty: Obstetrics and Gynecology • Oncology Objective: Rare disease Background: Gestational trophoblastic disease (GTD) encompasses a group of disorders that arise from abnormal growth of trophoblastic tissue. The spectrum of GTD includes 2 major groups: benign and malignant. The benign form is a hydatidiform mole, either complete or partial; the malignant forms, referred to as gestational trophoblastic neoplasia (GTN), consist of invasive moles, choriocarcinomas, placental site trophoblastic tumors, and epithelioid trophoblastic tumors. Most patients who undergo evacuation of a hydatidiform mole by curettage have a disease-free period before a new tumor develops that can be considered malignant. In rare cases, metastasis occurs rapidly and manifests coincidentally before the hydatidiform mole can be evacuated. Case Report: A 19-year-old woman in Bandung City, West Java, Indonesia, was diagnosed with a molar pregnancy with early evidence of a mass in her vagina that was suspicious for stage II GTN. The early emergence of a vaginal mass was a rare case of early transformation of a molar pregnancy into GTN. Conclusions: Careful evaluation is warranted of patients with characteristics typical of an intrauterine molar pregnancy who have an early presentation of a vaginal mass because of the possibility that the diagnosis could be GTN.

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“…If the germ cell tumors are relapsed or refractory to the salvage chemotherapy, autologous hematopoietic stem cell transplantation (AHSCT) can be used for the treatment like lymphoproliferative diseases and sarcomas (1,2). Though there are several cases of uterine choriocarcinoma metastatic to vulva, vagina or tuba (3-5), according to our knowledge, there are few cases of primary extrauterine vaginal choriocarcinoma and primary vulvar choriocarcinoma that have been reported in the literature (6,7). Additionally, it is the first and unique in the literature for undergoing AHSCT.…”

Section: Introductionmentioning

confidence: 99%

Primary vulvovaginal choriocarcinoma patient who underwent autologous hematopoetic stem cell transplantation: A case report of unusual presentation

Esen¹,

Mammadzada²,

Yıldız³

et al. 2018

Eastern J Med

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Ovarian germ cell tumors (GCT) are derived from primordial germ cells of the ovary. Choriocarcinomas are more commonly of placental than ovarian origin in a woman. Vaginal choriocarcinoma is seen very rare in the literature. If the germ cell tumors are relapsed or refractory to the salvage chemotherapy, autologous hematopoietic stem cell transplantation (AHSCT) can be used for the treatment. Our aim is to present a rare vaginal choriocarcinoma patient who underwent AHSCT due to the relapsed disease. A 46-year-old woman who had two vaginal deliveries 18 years ago, presented with a vaginal mass. The diagnosis was made as choriocarcinoma after abscess drainage. Due to the elevated levels of β-HCG, she had undergone chemotherapy. After the four lines chemotherapy serum tumor markers remained high. Because of that reason, AHSCT was performed and after the transplantation, the β-HCG level has decreased. The patient was observed with a very good partial response. According to current literature, AHSCT is a reasonable treatment option for relapsed or resistant cases. In conclusion, our case is the first and unique who has undergone AHSCT. AHSCT is an effective and tolerable treatment for ectopic relapsed and refractory choriocarcinoma cases.

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Metastatic vulvo-vaginal choriocarcinoma mimicking a Bartholin cyst and vulvar hematoma-two unusual presentations

Cited by 8 publications

References 5 publications

Choriocarcinoma with atypical presentations causing diagnostic dilemma

Choriocarcinoma with atypical presentations causing diagnostic dilemma

A Rare Case of Early Transformation of Gestational Trophoblastic Neoplasia Following Molar Pregnancy

Primary vulvovaginal choriocarcinoma patient who underwent autologous hematopoetic stem cell transplantation: A case report of unusual presentation

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