Metastatic Uterine Leiomyosarcoma Involving Bilateral Ovarian Stroma without Capsular Involvement Implies a Local Route of Hematogenous Dissemination

Dandapani, Monica; Seagle, Brandon Luke L.; Abdullah, Amer Hasan; Hatfield, Bryce; Samuelson, Robert; Shahabi, Shohreh

doi:10.1155/2015/950373

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…The evaluated immunohistochemical markers highlighted both the loss of myocyte differentiation and the overexpression of the p53 biomarker, results consistent with the aggressive biological potential of high grade uterine leiomyosarcoma. 9 …”

Section: Discussionmentioning

confidence: 99%

Morphological and Ancillary Features of Uterine Leiomyosarcoma: Case Report

Boşoteanu

Vodă

Aşchie

et al. 2022

Clin Med�Insights�Pathol

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We report a rare case of giant uterine leiomyosarcoma in a postmenopausal woman, whose diagnosis was initially suspected at the evaluation of the abdominal efusion, and confirmed after the pathological examination of the uterus in association with the ancillary tests. The evaluation of the abdominal fluid showed single or clusters of malignant, round or spindle-shaped cells. On microscopic examination of the surgical specimen, a dense cell proliferation of spindle cells, with moderate to severe nuclear pleomorphism and significant mitotic activity was observed. Immunohistochemical evaluation demonstrated the loss of myocytic differentiation by focal, weakly positive expression of smooth muscle actin and desmin. The data presented in this case emphasize the relevance of the cytological examination, although the latter has only indicative value, especially since it is an aggressive tumor, frequently associated with mutant expression of p53. In our case, the first indication of the presence of uterine sarcoma was given by the presence of atypical cells in the peritoneal fluid.

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Section: Discussionmentioning

confidence: 99%

Morphological and Ancillary Features of Uterine Leiomyosarcoma: Case Report

Boşoteanu

Vodă

Aşchie

et al. 2022

Clin Med�Insights�Pathol

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“…The most common primary sites are the retroperitoneum, including intra-abdominal sites (35%); the uterus (30%); the extremities (19%); and the trunk, including the head and neck as well as the chest (16%). [1–3] Wide resection is the standard treatment for leiomyosarcomas of the extremities and trunk. There is no evidence for the efficacy of neo-adjuvant and adjuvant chemotherapy.…”

Section: Introductionmentioning

confidence: 99%

Hepatic metastases from primary extremity leiomyosarcomas

et al. 2018

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The lung is the most common site of metastases from leiomyosarcomas of the extremeties, because these metastases are hematogenous. Both our patients presented with metastases of the liver, despite the absence of lung metastases. Hepatic metastasis is commonly found in computed tomography (CT) scan. Periodic CT scans of the chest and abdomen are necessary in following-up patients who undergo resection of primary leiomyosarcomas of the extremities.

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Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment

Wang

et al. 2017

BMC Cancer

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BackgroundUterine leiomyosarcoma (ULMS) is an aggressive form of soft tissue tumors. The molecular heterogeneity and pathogenesis of ULMS are not well understood.MethodsExpression profiling data were used to determine the possibility and optimal number of ULMS molecular subtypes. Next, clinicopathological characters and molecular pathways were analyzed in each subtype to prospect the clinical applications and progression mechanisms of ULMS.ResultsTwo distinct molecular subtypes of ULMS were defined based on different gene expression signatures. Subtype I ULMS recapitulated low-grade ULMS, the gene expression pattern of which resembled normal smooth muscle cells, characterized by overexpression of smooth muscle function genes such as LMOD1, SLMAP, MYLK, MYH11. In contrast, subtype II ULMS recapitulated high-grade ULMS with higher tumor weight and invasion rate, and was characterized by overexpression of genes involved in the pathway of epithelial to mesenchymal transition and tumorigenesis, such as CDK6, MAPK13 and HOXA1.ConclusionsWe identified two distinct molecular subtypes of ULMS responding differently to chemotherapy treatment. Our findings provide a better understanding of ULMS intrinsic molecular subtypes, and will potentially facilitate the development of subtype-specific diagnosis biomarkers and therapy strategies for these tumors.Electronic supplementary materialThe online version of this article (10.1186/s12885-017-3568-y) contains supplementary material, which is available to authorized users.

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Metastatic Uterine Leiomyosarcoma Involving Bilateral Ovarian Stroma without Capsular Involvement Implies a Local Route of Hematogenous Dissemination

Cited by 4 publications

References 12 publications

Morphological and Ancillary Features of Uterine Leiomyosarcoma: Case Report

Morphological and Ancillary Features of Uterine Leiomyosarcoma: Case Report

Hepatic metastases from primary extremity leiomyosarcomas

Distinct molecular subtypes of uterine leiomyosarcoma respond differently to chemotherapy treatment

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