Metastatic Urethral Obstruction

Selikowitz, Stuart M.; Olsson, Carl A.

doi:10.1001/archsurg.1973.01350240070020

Cited by 21 publications

(8 citation statements)

References 8 publications

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“…Although F-18 FDG PET/ CT is useful for detecting the primary site of the metastasis and silent lesions, F-18 FDG PET/CT was not performed or did not play a critical role in the detection of metastatic lesions to the urethra in previously reported cases [3,[6][7][8][9][10][11]. In our case, PET/CT revealed not only urethral metastasis, which was not detected by other diagnostic tools, but also aggravation after initial chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

“…The primary tumors that metastasize to the urethra originate from colon, lung, kidney and prostate cancer [1][2][3][4][5]. About ten cases of urethral metastasis from a primary colorectal cancer have been reported in the literature [3,[6][7][8][9][10][11]. It is frequently associated with widespread metastatic disease and poor prognosis clinically.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Urethral Metastasis from Sigmoid Colon Cancer Diagnostically and Prognostically Indicated by F-18 FDG PET/CT

Seo

Kim

et al. 2011

Nucl Med Mol Imaging

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Urethral metastasis from colorectal cancer is rare and is known to have a poor prognosis. A 72-year-old man with a history of colectomy and colostomy due to sigmoid colon cancer was admitted to the emergency room with bowel distension, rectal bleeding and urinary symptoms. Computed tomography of the abdominopelvis showed sigmoid colon cancer with multiple metastases involving the liver. Positron emission tomography with F-18 fluorodeoxyglucose (FDG) showed multiple hypermetabolic foci in the liver, penis and pubic bone, which otherwise could not be diagnosed. The lesions revealed no improvement with chemotherapy and urological surgery on follow-up F-18 FDG PET/CT. We present a case of urethral metastasis of sigmoid colon cancer diagnostically and prognostically indicated by F-18 FDG PET/CT.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Case of Urethral Metastasis from Sigmoid Colon Cancer Diagnostically and Prognostically Indicated by F-18 FDG PET/CT

Seo

Kim

et al. 2011

Nucl Med Mol Imaging

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“…However, not much information on urethral metastases from these primaries is available so far. To our knowledge, only 9 previous cases with metastases from colorectal cancer have been reported to date [2,5-10]. We report a case of urethral metastasis from a sigmoid colon carcinoma with remaining free of tumor for 34 months, mainly from immunohistopathological point of view to add to some knowledge about its management and mechanism for metastasis.…”

Section: Introductionmentioning

confidence: 90%

Urethral metastasis from a sigmoid colon carcinoma: a quite rare case report and review of the literature

et al. 2014

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BackgroundUrethral metastatic adenocarcinoma is extremely rare. Moreover, only 9 previous cases with metastases from colorectal cancer have been reported to date, and not much information on urethral metastases from colorectum is available so far.Case presentationWe report our experience in the diagnosis and the management of the case with urethral metastasis from a sigmoid colon cancer. A 68-year-old man, who underwent laparoscopic sigmoidectomy for sigmoid colon carcinoma four years ago, presented gross hematuria with pain. Urethroscopy identified a papillo-nodular tumor 7 mm in diameter in the bulbar urethra. CT-scan imaging revealed the small mass of bulbous portion of urethra and solitary lung metastasis. Histological examination of the tumor obtained by transurethral resection showed moderately differentiated adenocarcinoma, which was diagnosed as a metastasis of a sigmoid colon carcinoma pathologically by morphological examination. Immunohistochemical analysis of the urethral tumor revealed the positive for cytokertin 20 and CDX2, whereas negative for cytokertin 7. These features were consistent with metastatic adenocarcinoma of the sigmoid colon cancer. As the management of this case with urethral and lung metastasis, 6-cycle of chemotherapy with fluorouracil with leucovorin plus oxaliplatin was administered to the patient, and these metastases were disappeared with no recurrence of disease for 34 months.ConclusionUrethral metastasis from colorectal cancer is a very rare occurrence. However, in the presence of urinary symptoms, the possibility of the urethral metastasis should be considered.

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“…Primary adenocarcinoma of the colon and its metastatic lesions are strongly positive for cytokeratin 20 and negative for cytokeratin 7 [5]. The pathology is still uncertain, but possible mechanisms for metastatic spread may be due to direct extension, retrograde venous or retrograde lymphatic spread [1,6,7]. Atypical presentations of urethral lesions should be viewed with suspicion.…”

Section: Case Studymentioning

confidence: 99%