Metastatic Tumors to the Oral and Maxillofacial Region: A Retrospective Study of 19 Cases in West China and Review of the Chinese and English Literature

Shen, Molun; Kang, Jian; Wen, Yanli; Ying, Wei-Min; Yi, Jie; Hua, Chengge; Tang, Xiaodi; Wen, Yu-ming

doi:10.1016/j.joms.2008.06.032

Cited by 75 publications

(94 citation statements)

References 337 publications

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“…In a recent study, Shen et al [66] extensively reviewed the Chinese literature for metastatic tumors to the oral and maxillofacial region (OMF), with special emphasis to the differences in the constituent ratios of primary cancers between the United States and China. They revealed that metastases to the OMF from the lung, thyroid, liver, Fig.…”

Section: Origin Of the Primary Tumormentioning

confidence: 99%

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Metastatic Tumors to the Jaws and Mouth

Hirshberg

Berger

Allon

et al. 2014

Head and Neck Pathol

141

171

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Metastatic dissemination to the oral cavity is rare and is usually the evidence of a wide spread disease with an average survival rate of 7 months. In almost a quarter of the cases, oral metastasis was found to be the first indication of an occult malignancy at a distant site. Metastatic lesions can be found anywhere in the oral cavity, however, the jawbones with the molar area is the most frequently involved site. In the oral soft tissues, the gingiva is the most common site, suggesting the possible role of inflammation in the attraction of metastatic deposits. The most common primary malignancies presenting oral metastases were the lung, kidney, liver, and prostate for men, and breast, female genital organs, kidney, and colorectum for women. Most patients with jawbone metastasis complain of swelling, pain, and paresthesia. An exophytic lesion is the most common clinical presentation of metastatic lesions in the oral soft tissues. Early lesions, mainly those located in the gingiva, may resemble a hyperplastic or reactive lesion. Once a lesion is recognized as metastasis, the primary tumor site should be identified following clinical, radiological and histopathological investigations. If standardized diagnostic workup fails to detect the site of origin, then the term carcinoma of unknown primary is applied. Personalized medicine tools such as tissue-oforigin assays should be applied, either by immunohistochemical testing or by molecular-profiling methods as these may lead to a more favorable outcome.

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Section: Origin Of the Primary Tumormentioning

confidence: 99%

“…In most studies, CUP constitutes 3-5 % of all cancers [66][67][68][69] with a decreasing incidence of \2 % during the recent decades. However, variation exists in the definition of CUP between different epidemiological studies making the comparison difficult.…”

Section: Carcinoma Of Unknown Primarymentioning

confidence: 99%

Metastatic Tumors to the Jaws and Mouth

Hirshberg

Berger

Allon

et al. 2014

Head and Neck Pathol

141

171

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“…According to the results of rank correlation analysis in our previous work, there was no significant linear relationship between the constituent ratio of PTP and that of OMF metastases [8]. However, when it was narrowed down to MJ, a linear relationship was established between constituent ratio of PTP and that of MJ.…”

Section: Discussionmentioning

confidence: 81%

“…In one of our previous papers [8], the incidence of OMF metastases was found to be influenced by the PTP. However, there was no linear correlation between the two.…”

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confidence: 81%

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Primary tumor prevalence has an impact on the constituent ratio of metastases to the jaw but not on metastatic sites

et al. 2011

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This article provides an overview of metastases to jaws (MJ), mainly concerning the differences between American and Chinese patients, and exploring the relationship between the primary tumors' prevalence (PTP) and constituent ratio of MJ. Information concerning of 399 MJ cases in 215 papers, including one new case in our hospital, was subjected to statistic analysis. The main clinical features of MJ, such as constituent ratio of PTP and that of MJ, metastatic sites, treatments, and prognosis were summarized. Breast, lung, kidney, prostate and thyroid (in descending order) were the leading primary sites of MJ. Furthermore, the constituent ratio of MJ was found to be correlated with that of PTP in all subjects including American and Chinese subjects in our study. As to metastatic sites in the mandible, a specific "M" shaped pattern appeared regardless of the tumor type or constituent ratios of MJ were in all subjects. Almost all subjects received traditionally palliative treatments, and the prognosis was quite poor. The PTP had a significant impact on the constituent ratio of MJ. However, it was the properties of the microenvironment rather than characteristics or constituent ratios of tumor cells, that decided the metastatic sites in various tumor subjects.

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Invasion Patterns and Metastatic Patterns of Hepatocellular Carcinoma

Zimmermann

2016

Tumors and Tumor-Like Lesions of the Hepatobiliary Tract

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Metastatic Tumors to the Oral and Maxillofacial Region: A Retrospective Study of 19 Cases in West China and Review of the Chinese and English Literature

Cited by 75 publications

References 337 publications

Metastatic Tumors to the Jaws and Mouth

Metastatic Tumors to the Jaws and Mouth

Primary tumor prevalence has an impact on the constituent ratio of metastases to the jaw but not on metastatic sites

Invasion Patterns and Metastatic Patterns of Hepatocellular Carcinoma

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