Metastatic tumors of the umbilicus

Barrow, Mark V.

doi:10.1016/0021-9681(66)90144-5

Cited by 116 publications

(82 citation statements)

References 6 publications

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“…It is an indication of poor prognostic outcome where palliation is the mainstay of patient management. Also, an estimated 1-3% of abdomino-pelvic malignancies arising from the stomach, pancreas, colon, prostate and liver manifest with umbilical metastasis (7,(10)(11)(12)(13). Other uncommon primary origins include the breast, lung, ovary and kidney.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous umbilical metastases in post-menopausal females with gynaecological malignancies

Samaila

Adesiyun

Waziri

et al. 2012

J Turkish German Gynecol Assoc

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Gynaecological malignancies frequently metastasize to contiguous structures, internal organs and bones. Cutaneous metastasis as a primary or recurrent presentation of these malignancies is rare and only a few cases have been reported in the literature. A twenty year (1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010) retrospective search for umbilical metastasis from gynaecological malignancies in our departmental case records showed only four cases. Four postmenopausal females presented with painful cutaneous umbilical (Sister Joseph's) nodules. The clinical examinations of all four patients revealed well delineated nodules of varying sizes and degrees of ulceration. Other findings were matted axillary and inguinal lymph node enlargement, intra-abdominal and pelvic masses, vaginal discharge and vaginal bleeding. Incisional tissue biopsies from the nodules were processed in paraffin wax and stained with haematoxylin and eosin. Histology of the sections showed pigmented skin overlying metastatic malignant tumours consistent with adenocarcinoma from the endometrium and ovary in three cases, and squamous cell carcinoma, large cell keratinizing from the cervix uteri in the fourth case. Gynaecological cancers have a global spread and varied geographic distribution. Cervical cancer is the commonest in our setting and patients often present to hospital with advanced stage disease. Ovarian and endometrial cancers are infrequent and their diagnosis may be delayed by non-specificity of presenting clinical symptoms from other benign tumours at these sites. Although umbilical metastasis is commonly associated with gastro-intestinal malignancies, its presence may be the first harbinger of occult gynaecologic cancer. (J Turkish-German Gynecol Assoc 2012; 13: 204-7)Key words: Metastasis, umbilical, cervix uteri, squamous cell carcinoma, endometrial adenocarcinoma Received: 04 November, 2011 Accepted: 03 January, 2012Jinekolojik maligniteler sıklıkla komşu yapılara, iç organlara ve kemiklere metastaz yaparlar. Bu malignitelerin primer veya rekürren prezentasyonu olarak deri metaztazları enderdir ve literatürde sadece bir kaç olgu bildirilmiştir. Jinekolojik malignitelerden kaynaklanan umbilikal metaztazlar için departmanımızın olgu kayıtlarında yirmi yıllık (1991-2010) retrospektif taramada sadece dört olgu bulundu. Menopoz sonrası dört kadın deriyi tutan ağrılı umbilikal nodüllerle (Rahibe Joseph) başvurmuştu. Dört hastanın klinik muayenesi farklı büyüklükte ve farklı ülserasyon derecelerinde iyi sınırlanmış nodülleri ortaya koymuştu. Diğer bulgular aksillar ve inguinal lenf nodlarında paket halinde büyüme, karın içi ve pelvik kitleler, vajinal akıntı ve vajinal kanama idi. Nodüllerden insizyonla elde edilen doku biyopsileri parafin mumunda işlenmiş ve hematoksilin-eozin ile boyanmıştı. Kesitlerin histolojisi üç olguda endometriyum ve overden köken alan adenokarsinoma ile uyumlu metastatik malign tümör ve üstünü örten pigmente deriyi, dördüncü olguda servik...

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Section: Discussionmentioning

confidence: 99%

Cutaneous umbilical metastases in post-menopausal females with gynaecological malignancies

Samaila

Adesiyun

Waziri

et al. 2012

J Turkish German Gynecol Assoc

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“…It is typically less than 5 cm in diameter averaging 1-1.5 cm in diameter but occasionally enlarges up to 10 cm to form a protruding tumor. 2 The nodule has been described as white, bluish violet or brownish red and is occasionally pruritic. Patients with Sister Mary Joseph nodule present with a number of clinical symptoms consistent with intra-abdominal cancer including epigastric pain, abdominal distension, weight loss, nausea, ascites and bleeding per rectum.…”

Section: Case Reportmentioning

confidence: 99%

“…Histology of the metastatic umbilical tumor usually reveals adenocarcinoma but rare reports of umbilical metastasis from sarcomas, mesotheliomas and melanomas have also been seen. [2][3][4][5][6] CT Scan (abdomen and chest) and Fine Needle Aspiration Cytology (FNAC) of the tumor are invaluable in the diagnosis of Sister Mary Joseph nodule and help to exclude a primary benign umbilical neoplasm. In 14-33% of cases, umbilical metastases lead to the diagnosis of previously occult neoplasms.…”

Section: Case Reportmentioning

confidence: 99%

“…Gastrointestinal malignancies account for about half of the underlying sources (gastric, colonic, pancreatic cancer), gynecologic (ovarian, uterine cancer), unknown primary tumors and rarely bladder or respiratory malignancies cause umbilical metastasis. 2 Mechanism of spread of cancer to the umbilicus is unknown but proposed mechanisms include direct transperitoneal spread via lymphatic running along the obliterated umbilical vein, hematogenous spread or via remnant structures like the falciform ligament, median umbilical ligament or a remnant of the umbilical duct. 3 Sister Mary Joseph nodule is associated with multiple peritoneal metastases and signifies a poor prognosis.…”

Section: Introductionmentioning

confidence: 99%

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A rare case of Sister Mary Joseph nodule as the only sign of unknown primary malignancy

et al. 2016

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“…Typically, smjn will be a firm irregular nodule, averaging in size from 1 cm to 1.5 cm, and occasionally reaching a maximum of 10 cm in diameter 4 . Sister …”

Section: Introductionmentioning

confidence: 99%

Umbilical Metastasis: A Case Series of Four Sister Joseph Nodules from Four Different Visceral Malignancies

et al. 2010

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Sister Joseph nodule is a metastatic umbilical lesion secondary to a primary malignancy of any viscera. It can be a presenting symptom (a sign of undiagnosed malignancy) or a symptom or sign of progression or recurrence in a known case. Its incidence is 1–3% of all intra-abdominal or pelvic malignancies. Here, we present 4 such cases, with Sister Joseph nodule as a finding of (1) presentation in a case of gallbladder carcinoma, (2) progression in a case of malignant gastrointestinal stromal tumour, (3) recurrence in a case of ovarian carcinoma, and (4) presentation in a case of rectal carcinoma. The clinicopathologic features of all 4 patients are discussed, and the related literature is briefly reviewed.

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Metastatic tumors of the umbilicus

Cited by 116 publications

References 6 publications

Cutaneous umbilical metastases in post-menopausal females with gynaecological malignancies

Cutaneous umbilical metastases in post-menopausal females with gynaecological malignancies

A rare case of Sister Mary Joseph nodule as the only sign of unknown primary malignancy

Umbilical Metastasis: A Case Series of Four Sister Joseph Nodules from Four Different Visceral Malignancies

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