Metastatic Tumors of the Ovary

Lerwill, Melinda F.; Young, Robert H.

doi:10.1007/978-1-4419-0489-8_18

Cited by 10 publications

(8 citation statements)

References 164 publications

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“…16 If the ovarian metastasis is discovered prior to its renal source, then a subjective tumour pattern recognition on an ultrasound may lead to a misdiagnosis of primary ovarian clear cell carcinoma (also typically presented as a unilateral mass with a mean size of 13 to 15 cm, 17 or as a granulosa-cell tumour. 18 In an ultrasound, solid tumous containing several small, irregular locules or multilocularsolid tumours are usually depicted.…”

Section: Discussionmentioning

confidence: 99%

Ovarian metastasis of clear cell renal cell carcinoma: A case report

Bauerová

Dundr

Fischerová

et al. 2014

CUAJ

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We report on a 61-year-old woman with a history of right-sided nephrectomy for clear cell renal cell carcinoma (RCC) occurring 21 years ago; she currently presented with a bilateral ovarian tumour. Histologically, the tumour of both ovaries was clear cell carcinoma. Immunohistochemically, the tumour cells were positive for vimentin, RCC marker, epithelial membrane antigen, cytokeratin AE1/3 and CD10. Cytokeratin 7, CA125, HMWCK, estrogen and progesterone receptors were all negative. Based on the morphology and immunophenotype of the tumour, we established a diagnosis of late metastasis of RCC in the ovaries. A postoperative abdominal computed tomography scan, however, revealed a tumour mass solely in the left kidney, which had not been visible in the preoperative ultrasound. The patient underwent nephron-sparing surgery and a biopsy showed the tumour to be clear cell RCC. Metastasis of RCC to the ovaries is rare, and to the best of our knowledge, only 24 cases have been reported to date. However, due to the different treatments and prognosis, the distinction between a primary ovarian tumour and metastasis of RCC is important.

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Section: Discussionmentioning

confidence: 99%

Ovarian metastasis of clear cell renal cell carcinoma: A case report

Bauerová

Dundr

Fischerová

et al. 2014

CUAJ

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“…They are usually bilateral in contrast to primary ovarian lesions, which are usually unilateral. Although most metastatic carcinoids are of small intestinal origin, rarely the primary tumor originates in the appendix, colon, stomach, pancreas, or lung [2].…”

Section: Discussionmentioning

confidence: 99%

“…The latter are uncommon and often associated with a mature cystic teratoma. Of the metastatic carcinoids, the insular carcinoid tumor is the most common, followed by the trabecular and mucinous types [2]. According to the literature, the insular and trabecular subtypes most commonly have metastases in the ovary simulating a primary tumour.…”

Section: Discussionmentioning

confidence: 99%

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A Rare Association of Unilateral Borderline Mucinous Cystadenoma of Ovary with Ileal Neuroendocrine Tumor Metastasis

Mb¹,

Cp²,

Vs³

et al. 2015

JCR

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Introduction: Neuroendocrine tumors of the female genital tract, either primary or secondary are rare. Ovarian metastasis from a neuroendocrine tumor in particular is a rare event with about 60 cases cited in the literature. Ovarian metastases are bilateral in approximately 70% of cases. Case Report: A 50 year old female presented with pain abdomen and CT abdomen revealed left ovarian cyst. During laparotomy, an ileal growth was identified. Ileal resection, anastomosis and bilateral salpingoophorectomy were done. Conclusion: Unilateral ovarian metastasis, though a rare event, is a critical issue in the management of neuroendocrine tumors. We present this case in view of its rare association.

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“…The ovary is a common site of metastases from malignant tumors, with 5–20% of ovarian masses being metastases from primary tumors in other organs. Metastases to the ovaries occur more often by hematogenous spread than by extension per continuitatem. Their development is predominantly metachronous (after the diagnosis of the primary tumor) rather than synchronous, with a disease‐free interval of about 3 years.…”

Section: Introductionmentioning

confidence: 99%

Role of CA125/CEA ratio and ultrasound parameters in identifying metastases to the ovaries in patients with multilocular and multilocular‐solid ovarian masses

Moro

Pasciuto

Djokovic

et al. 2019

Ultrasound in Obstet & Gyne

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350 (88.4%) patients with an ovarian neoplasm (including 99 benign, 43 borderline, 197 primary epithelial ovarian carcinomas, 7 malignant rare tumors and 4 other types of invasive ovarian tumor) and 46 (11.6%) patients with an ovarian metastasis were analyzed. At ultrasound, ovarian neoplasms were smaller than ovarian metastases (median of the largest diameter: 97, range 20-387 mm, versus 146, range 43-259 mm) (p<0.0001) and presented with a lower number of cysts with >10 locules (18.9% versus 54.3%) (< 0.0001). Receiver operating characteristic curve (ROC) analysis showed that the best cut-off value of CEA for predicting ovarian neoplasms versus ovarian metastases was 2.33 ng/mL. The predictive performance of the CEA cut-off value was: AUC 0.791 (95%CI 0.711-0870), accuracy 73.7%, sensitivity 73.1%, specificity 78.3%, PPV 96.2% and NPV 27.7%. The best cut-off value of CA125/CEA ratio for predicting ovarian neoplasms versus ovarian metastases was 11.92. The predictive performance of the CA125/CEA cut-off value was: AUC of 0.758 (95%CI 0.683-0.833), accuracy 79.8%, sensitivity 82.3%, specificity 60.9% PPV 94.1% and NPV 31.1% CONCLUSIONS: CA125/CEA ratio and CEA alone did not show any significant difference in distinguishing ovarian neoplasms (including benign and malignant) from ovarian metastases in masses with multilocular and multilocular-solid morphology. Therefore, in this morphological subgroup of ovarian masses, CEA alone is enough to use for differentiating between the ovarian neoplasms and ovarian metastases. This article is protected by copyright. All rights reserved.

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Metastatic Tumors of the Ovary

Cited by 10 publications

References 164 publications

Ovarian metastasis of clear cell renal cell carcinoma: A case report

Ovarian metastasis of clear cell renal cell carcinoma: A case report

A Rare Association of Unilateral Borderline Mucinous Cystadenoma of Ovary with Ileal Neuroendocrine Tumor Metastasis

Role of CA125/CEA ratio and ultrasound parameters in identifying metastases to the ovaries in patients with multilocular and multilocular‐solid ovarian masses

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