Metastatic Thyroid Carcinoma Presenting as Hypervascular Lesion of the Mandible: A Case Report and Review of Literature

Kumar, Rayadurgam Venkata Kishore; Chakravarthy, Chitra; Sekhar, Gali Raja; Devireddy, Sathya Kumar; Kumaravelu, C.; Kare, Anupama

doi:10.1016/j.joms.2009.10.004

Cited by 12 publications

(9 citation statements)

References 7 publications

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“…However, in the current case, both the incisional and the excisional biopsy showed a pure PTC pattern. The clinical signs of FTC or FV-PTC may be similar to arteriovenous malformations because they are highly vascular [2,9]. Our patient also complained about bleeding from the lesion.…”

Section: Discussionmentioning

confidence: 59%

Mandibular Metastasis of Silent Papillary Thyroid Carcinoma: A Rare Case Report with Review of the Literature

Gholami

Bakhshi

Atarbashi-Moghadam

et al. 2020

Case Reports in Dentistry

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Metastasis to the jaws is a rare event; however, it has great importance because it may be the only symptom of an undiagnosed underlying malignancy. Papillary thyroid carcinoma, the commonest histopathologic variant of thyroid cancer, has minimal potential for distant metastasis, and most reported metastatic thyroid carcinomas of the oral cavity have been follicular thyroid carcinoma. The aim of this article is to present a rare case of metastatic papillary thyroid carcinoma, which presented itself as a painless expansion in the anterior region of the mandible in a 56-year-old female, and to review previously published cases of this type of cancer. Reporting rare cases such as this one, together with reviewing previous reports of related rare diseases, will expand the body of knowledge about these uncommon lesions.

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Section: Discussionmentioning

confidence: 59%

Mandibular Metastasis of Silent Papillary Thyroid Carcinoma: A Rare Case Report with Review of the Literature

Gholami

Bakhshi

Atarbashi-Moghadam

et al. 2020

Case Reports in Dentistry

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“…A rapid progression of intraoral or extraoral swelling associated with chin paresthesia and pain is not uncommon [21, 29, 36, 53]. As the tumor invades oral mucosa, a granulation-like mass may form and result in significant bleeding, infection, fractures, and disturbances in swallowing and mastication [32, 40]. …”

Section: Discussionmentioning

confidence: 99%

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

et al. 2017

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BackgroundFollicular thyroid carcinoma (FTC) metastasis to the facial skeleton is exceedingly rare. A case of FTC metastasizing to the mandible is presented and a systematic review of the literature describing thyroid metastasis to the facial skeleton is performed.Case presentationA 73-year-old female presented with metastatic FTC to the mandible and underwent total thyroidectomy, segmental mandibulectomy, bone impacted fibular free flap reconstruction, and adjuvant radioactive iodine treatment. The PubMed database was searched for literature describing thyroid cancer with facial skeleton metastasis using the key words “thyroid,” “cancer,” “carcinoma,” “metastasis,” and “malignancy” with “oral cavity,” “maxilla,” “mandible,” “sinus,” “paranasal,” and “orbit.” Reports that only involved the soft tissues were excluded. Systematic review revealed 59 cases of well-differentiated thyroid cancer with facial skeleton metastasis: 35 mandibular metastases (21 = FTC), 6 maxilla metastases (2 = FTC), 9 orbital metastases (4 = FTC), and 11 paranasal sinus metastases (7 = FTC). Treatment included surgery, RAI, external beam radiotherapy (XRT), or a combination of these modalities. The one, two, and five-year survival rates were 100%, 79%, and 16%, respectively.ConclusionFacial skeleton metastasis of FTC is a rare clinical challenge. Optimal treatment appears to include total thyroidectomy and resection of involved structures with or without adjuvant treatment.

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“…Interestingly, oral metastases may mimic an inflammatory condition, such as periodontitis, periapical lesions, osteomyelitis, or pericoronitis or present as a pathologic fracture [26,39]. It should be noted that metastatic follicular thyroid carcinoma frequently has a highly vascular nature, often causing pulsation and/or bruit on auscultation and eliciting a clinical diagnosis of arteriovenous malformation; in such cases, preoperative angiographic evaluation and devascularisation by embolization and/or ligation are necessary precautions to avoid potentially significant bleeding [9,18,22,24,26,32,41].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Papillary Thyroid Carcinoma to the Maxilla: Case Report and Literature Review

Nikitakis

Polymeri

Polymeris

et al. 2011

Head and Neck Pathol

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Metastatic tumors to the oral cavity are uncommon and a thyroid origin is considered exceedingly rare. A case of metastatic papillary thyroid carcinoma (PTC) presenting as a painful swelling in the right posterior maxilla of a 63-year-old male is reported here. The patient had been diagnosed with PTC 2 years ago and treated with thyroidectomy and radioactive iodine treatment. Radiographically, the metastatic lesion presented as a poorly-defined radiolucent lesion around an impacted maxillary third molar in the right maxilla. Histopathologic examination revealed features of PTC which was immunohistochemically positive for pancytokeratin, keratin 19 and thyroglobulin. Imaging studies revealed the presence of residual maxillary and neck disease as well as additional metastatic lesions in the sternum, ribs, and left tibia. A thorough review of the English language literature revealed only 36 previously published cases of thyroid cancer metastases to the oral cavity, the demographic and clinicopathologic features of which are summarized.

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Metastatic Thyroid Carcinoma Presenting as Hypervascular Lesion of the Mandible: A Case Report and Review of Literature

Cited by 12 publications

References 7 publications

Mandibular Metastasis of Silent Papillary Thyroid Carcinoma: A Rare Case Report with Review of the Literature

Mandibular Metastasis of Silent Papillary Thyroid Carcinoma: A Rare Case Report with Review of the Literature

Follicular thyroid carcinoma metastasis to the facial skeleton: a systematic review

Metastatic Papillary Thyroid Carcinoma to the Maxilla: Case Report and Literature Review

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