Metastatic thymoma in the liver of a dog

Wiles, Valerie; Haddad, Jamie L.; Leibman, Nicole F.; Avery, Anne C.; Hughes, Ken

doi:10.1177/1040638718791222

Cited by 4 publications

(3 citation statements)

References 16 publications

(27 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hughes and Borman reported adiaspiromycosis in a wild European rabbit ( Oryctolagus cuniculus ), which showed a bleb-like structure of the outermost layer on the surface. Bleb-like structures similar to those were found during our observations [ 22 ]. Multinucleate giant cells surrounded adiaspores shown in Additional file 2 resemble those of an earlier report of a study conducted by Hughes and Borman [ 22 ].…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model

Takeshige

Nakano

Kondoh

et al. 2020

Vet Res

View full text Add to dashboard Cite

Lesions of adiaspiromycosis, a respiratory disease affecting wild animals, have been found mainly in dead mammals and free-living mammals captured for surveillance. No report has described an investigation of adiaspore formation progress in the lung. After establishing an experimental mouse model of intratracheal adiaspiromycosis infection with the causative agent Emmonsia crescens, we observed adiaspore development. The spores grew and reached a plateau of growth at 70 days post-infection. The median adiaspore diameter showed a plateau of around 40 μm. The characteristic three-layer cell-wall structure of adiaspores was observed in the lung at 70 days post-infection. We examined infection with a few spores, which revealed that adiaspores in the mouse lung progressed from intratracheal infection of at least 400 spores. Moreover, we developed adiaspores in vitro by culture in fetal bovine serum. Although most spores broke, some large spores were intact. They reached about 50 μm diameter. Thick cell walls and dense granules were found as common points between in vitro adiaspores and in vivo adiaspores. These models are expected to be useful for additional investigations of E. crescens adiaspores and adiaspiromycosis.

show abstract

Section: Discussionsupporting

confidence: 89%

“…Bleb-like structures similar to those were found during our observations [ 22 ]. Multinucleate giant cells surrounded adiaspores shown in Additional file 2 resemble those of an earlier report of a study conducted by Hughes and Borman [ 22 ].…”

Section: Discussionsupporting

confidence: 89%

Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model

Takeshige

Nakano

Kondoh

et al. 2020

Vet Res

View full text Add to dashboard Cite

show abstract

“…Metastases may occur in regional intrathoracic lymph nodes and the lungs in up to 20% of cases [ 1 ] but are rarely diagnosed at presentation. Rare reports of metastasis to other organs, such as the liver, have been reported [ 36 ]. One dog in this study developed liver metastasis, which was diagnosed at necropsy; this dog had a diagnosis of thymoma, but this finding may raise the suspicion of a diagnostic error.…”

Section: Discussionmentioning

confidence: 99%

Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery

Martano

Buracco

Morello

2021

Animals

View full text Add to dashboard Cite

Thymoma is a tumor rarely reported in dogs and should be differentiated from mediastinal lymphoma. Clinical signs may have a late onset, and thymoma is often diagnosed when symptoms related to the space-occupying effect or paraneoplastic syndromes occur. CT and fine-needle aspirates or core biopsies are helpful in differential diagnosis, but flow cytometry may improve the pre-operative diagnostic ability. Concurrent paraneoplastic syndromes such as myasthenia gravis and hypercalcemia have been reported; however, their role as prognostic factors is not well determined. Surgical excision is the treatment of choice; adjuvant radiotherapy and/or chemotherapy may prolong survival in cases of incomplete excision or when a thymic carcinoma is diagnosed. Local recurrence and metastasis are infrequently reported; therefore, a long survival time is expected if the tumor is completely excised or if adjuvant therapy is undertaken. This article reports the authors’ experience with 28 dogs affected by 18 thymomas and 10 thymic carcinomas. The median overall survival in this series was 1173 days, and the median disease-free interval was 903 days. Dogs with thymic carcinoma had significantly shorter disease-free intervals and shorter, although not statistically significant, survival times. Dogs with Masaoka Stage III tumors had worse outcomes.

show abstract

Hemolymphatic System

Worley¹

2022

Veterinary Surgical Oncology

View full text Add to dashboard Cite

Metastatic thymoma in the liver of a dog

Cited by 4 publications

References 16 publications

Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model

Adiaspore development and morphological characteristics in a mouse adiaspiromycosis model

Canine Epithelial Thymic Tumors: Outcome in 28 Dogs Treated by Surgery

Hemolymphatic System

Contact Info

Product

Resources

About