Metastatic squamous cell carcinoma thyroid from functionally cured cancer cervix

Vamsy, Mohana; Dattatreya, Palanki Satya; Sarma, Lella Yugandhar; Dayal, Monal; Janardhan, Nandigam; Rao, Vatturi Venkata Satya Prabhakar

doi:10.4103/0972-3919.118252

Cited by 6 publications

(3 citation statements)

References 7 publications

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“…Metastasis of cervical cancer to the thyroid gland is rare, with only 14 cases having been reported, including our case ( Table 1 ) 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 . The mean age of the reported patients was 55 years (range: 36–72 years; n = 14).…”

Section: Discussionmentioning

confidence: 74%

Thyroid metastasis from cervical carcinoma

Hayashi¹,

Kumai²,

Michizuka³

et al. 2023

Brazilian Journal of Otorhinolaryngology

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Section: Discussionmentioning

confidence: 74%

Thyroid metastasis from cervical carcinoma

Hayashi¹,

Kumai²,

Michizuka³

et al. 2023

Brazilian Journal of Otorhinolaryngology

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“…They develop either due to the metaplastic transformation of follicular epithelial cells or from a remnant of the thyroglossal duct wall. 5 In case of primary squamous cell carcinoma (SCC), thyroid neoplastic cells arise from thyroidal cells and this transformation is noticed histologically, while in this study thyroidal component was well demarcated from the neoplastic cells suggesting metastatic infiltration. Immunohistochemically, negative staining with thyroglobulin, TTF-1, and calcitonin ruled out primary malignancy.…”

Section: Case Descriptionmentioning

confidence: 66%

“…The metastatic tumor can be synchronous or metachronous and the patient with the metachronous disease is known to have better survival. 5 The mean latency between diagnosing primary malignancy and its metastases is longest for sarcoma (~70 months) and shortest in lung cancer (4.5 months). 1 In our patient, the metastatic disease developed when she was receiving her last fraction of radiotherapy, thereby making it a synchronous growth.…”

Section: Case Descriptionmentioning

confidence: 99%

A Synchronous Metastatic Growth in Thyroid Gland from Carcinoma Cervix

Babu¹,

Ramakant²,

Mishra³

et al. 2019

World Journal of Endocrine Surgery

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Aim: To describe a rare case of synchronous carcinoma cervix metastasizing to the thyroid, while the patient being of therapy for primary cancer. Background: Metastasis to thyroid primarily occurs from lung, kidney, gastrointestinal tract (GIT), and head and neck. Cervix cancer metastasis to thyroid had been rarely reported. Case description: We report an unsealed case of carcinoma cervix metastasizing to the thyroid gland, while being on concurrent chemoradiotherapy for primary malignancy and total thyroidectomy was performed as palliative management. Pathological examination confirmed the thyroid lesion as metastasizing squamous cell carcinoma from the cervix. The postoperative period was uneventful and the patient was referred to radiotherapy department but later developed thrombosis in major neck veins and developed the superior vena cava syndrome. The patient finally succumbed to the disease after 3 weeks. Conclusion: Very few cases of cervix cancer metastasis to thyroid have been reported so far. Synchronous metastasis in such cases is even rarer. Hence, any patients who presents with palpable nodules in the thyroid and have a history of a previous malignancy must be considered for metastatic disease and in female patients the possibility of metastasis from the cervix should be considered and managed as well as evaluated accordingly. Clinical significance: Synchronous metastatic growth in the thyroid is known to have a poor prognosis and although total thyroidectomy is not recommended in metastatic disease, but can be performed as a part of palliative treatment.

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The prediction of candidate genes for cervix related cancer through gene ontology and graph theoretical approach

et al. 2014

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With rapidly changing technology, prediction of candidate genes has become an indispensable task in recent years mainly in the field of biological research. The empirical methods for candidate gene prioritization that succors to explore the potential pathway between genetic determinants and complex diseases are highly cumbersome and labor intensive. In such a scenario predicting potential targets for a disease state through in silico approaches are of researcher's interest. The prodigious availability of protein interaction data coupled with gene annotation renders an ease in the accurate determination of disease specific candidate genes. In our work we have prioritized the cervix related cancer candidate genes by employing Csaba Ortutay and his co-workers approach of identifying the candidate genes through graph theoretical centrality measures and gene ontology. With the advantage of the human protein interaction data, cervical cancer gene sets and the ontological terms, we were able to predict 15 novel candidates for cervical carcinogenesis. The disease relevance of the anticipated candidate genes was corroborated through a literature survey. Also the presence of the drugs for these candidates was detected through Therapeutic Target Database (TTD) and DrugMap Central (DMC) which affirms that they may be endowed as potential drug targets for cervical cancer.

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Metastatic squamous cell carcinoma thyroid from functionally cured cancer cervix

Cited by 6 publications

References 7 publications

Thyroid metastasis from cervical carcinoma

Thyroid metastasis from cervical carcinoma

A Synchronous Metastatic Growth in Thyroid Gland from Carcinoma Cervix

The prediction of candidate genes for cervix related cancer through gene ontology and graph theoretical approach

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