Metastatic spinal cord compression as a result of the unknown primary tumour

Quraishi, Nasir A.; Ramoutar, Darryl; Sureshkumar, D.; Manoharan, Sakthivel Rajan Rajaram; Spencer, A.; Arealis, Georgios; Edwards, Kimberly L.; Boszczyk, Bronek M.

doi:10.1007/s00586-014-3274-2

Cited by 17 publications

(19 citation statements)

References 26 publications

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“…Radiotherapy and chemotherapy using as adjuvant treatment for spinal MPG were usually advocated [2,12,29,30]. Radiotherapy with a total of 30-50 Gy had been reported to be helpful for the treatment of spinal MPG [2,6,12,15,30].…”

Section: Discussionmentioning

confidence: 99%

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Treatment and outcome of metastatic paraganglioma of the spine

et al. 2017

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Background Spinal metastatic paraganglioma (MPG) is rare and only reported in individual case reports. The low incidence makes it difficult to define appropriate therapy and prognosis. Our study illustrated the largest series to discuss the possible treatment and outcomes of patients with spinal MPG. Methods A retrospective study of 15 patients with spinal MPG who were surgically treated between 2005 and 2014 was performed. Three surgical modalities were applied, and radiotherapy and chemotherapy were utilized as adjuvant therapy. Results The mean patients age was 40.9 (range 23-58) years. The period between primary surgery and spinal metastasis averaged 8.2 (0.5-15) years. Lesions were mainly located in cervical spine (2), thoracic spine (8), lumbar spine (3), and sacrum (2). The mean follow-up period was 35.0 months. Lesion progression was detected in nine patients, whereas five patients (33.3%) passed away. For solitary spine, multiple bone and both bone and nonosseous metastasis cases, the mean progression-free survival was 41 (range 9-56), 22.5 (range 12-38) and 8.3 (range 3-18) months, respectively. Conclusions The cases presented in the current study highlight the crucial role of surgery. Total en bloc for solitary spinal MPG could result in a satisfying prognosis and piecemeal total resection with postoperative radiotherapy could be an alternative therapy. Radiotherapy and chemotherapy were advocated, especially for the multiple metastasis.

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Section: Discussionmentioning

confidence: 99%

“…Radiotherapy with a total of 30-50 Gy had been reported to be helpful for the treatment of spinal MPG [2,6,12,15,30]. Mertens et al [28] had reported initial chemotherapy including cyclophosphamide, vincristine and dacarbazine could alleviate symptoms at metastatic sites.…”

Section: Discussionmentioning

confidence: 99%

Treatment and outcome of metastatic paraganglioma of the spine

et al. 2017

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“…2012, Quraishi et al. 2014) that have suggested that the prognosis differs between patients whose primary tumor is located and patients whose primary tumor remains unknown.…”

Section: Discussionmentioning

confidence: 99%

“…2012, Quraishi et al. 2014). The difference may be explained to some extent by the different patient material with a high percentage of patients with prostate cancer, myeloma, and lymphoma—and consequently by a higher detection rate of primary tumors in our study.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic spinal cord compression as the first sign of malignancy

et al. 2017

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Background and purposeMetastatic spinal cord compression (MSCC) as the initial manifestation of malignancy (IMM) limits the time for diagnostic workup; most often, treatment is required before the final primary tumor diagnosis. We evaluated neurological outcome, complications, survival, and the manner of diagnosing the primary tumor in patients who were operated for MSCC as the IMM.Patients and methodsRecords of 69 consecutive patients (51 men) who underwent surgery for MSCC as the IMM were reviewed. The patients had no history of cancer when they presented with pain (n = 2) and/or neurological symptoms (n = 67).ResultsThe primary tumor was identified in 59 patients. In 10 patients, no specific diagnosis could be established, and they were therefore defined as having cancer of unknown primary tumor (CUP). At the end of the study, 16 patients were still alive (median follow-up 2.5 years). The overall survival time was 20 months. Patients with CUP had the shortest survival (3.5 months) whereas patients with prostate cancer (6 years) and myeloma (5 years) had the longest survival. 20 of the 39 patients who were non-ambulatory preoperatively regained walking ability, and 29 of the 30 ambulatory patients preoperatively retained their walking ability 1 month postoperatively. 15 of the 69 patients suffered from a total of 20 complications within 1 month postoperatively.InterpretationPostoperative survival with MSCC as the IMM depends on the type of primary tumor. Surgery in these patients maintains and improves ambulatory function.

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Patient-oncologist alliance and psychosocial well-being in Chinese society strongly affect cancer management adherence with cancer of unknown primary

Liang³

et al. 2016

Psycho-Oncology

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Metastatic spinal cord compression as a result of the unknown primary tumour

Cited by 17 publications

References 26 publications

Treatment and outcome of metastatic paraganglioma of the spine

Treatment and outcome of metastatic paraganglioma of the spine

Metastatic spinal cord compression as the first sign of malignancy

Patient-oncologist alliance and psychosocial well-being in Chinese society strongly affect cancer management adherence with cancer of unknown primary

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