Metastatic signet-ring cell carcinoma of the urinary bladder: A novel management approach to a rare tumor.

Pugashetti, Neil; Yap, Stanley A.; Lara, Primo N.; Gandour‐Edwards, Regina; Dall′Era, Marc

doi:10.5489/cuaj.2447

Cited by 12 publications

(11 citation statements)

References 14 publications

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“…6 When encountering bladder SRCC, metastasis from another site, commonly the gastrointestinal tract, should be ruled out. 8 In conclusion, we describe CSF cytology and brain histologic findings of metastatic primary bladder SRCC. A distinctive primary bladder SRCC immunoprofile has not yet been described.…”

Section: Discussionmentioning

confidence: 85%

“…This patient with lymph node and spinal metastasis responded well to a modified FOLFOX-6 regimen commonly used to treat metastatic gastrointestinal malignancies. 8 In conclusion, we describe CSF cytology and brain histologic findings of metastatic primary bladder SRCC. This unique complication proved to be rapidly progressive and fatal.…”

Section: Discussionmentioning

confidence: 85%

“…SRCC of the bladder is characterized by early invasion into adjacent structures, advanced stage at diagnosis, 8 increased rate of metastatic spread, positive soft tissue resection margins, and decreased overall survival. 9 We were able to identify the origin of the patient's CSF SRCC by comparison with his bladder biopsies.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic Signet‐Ring Cell Carcinoma of the Bladder in Cerebrospinal Fluid

Lin

Park

Gattuso

2016

Diagnostic Cytopathology

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Primary bladder signet-ring cell carcinoma (SRCC) is extremely rare and associated with an aggressive course. To our knowledge, we describe the first metastatic bladder SRCC identified in cerebrospinal fluid (CSF). A 68-year-old male with 1 year history of primary bladder SRCC with spinal metastasis presented with multiple falls and loss of consciousness. Brain imaging showed high signal in the frontoparietal sulci and superior cerebellum. CSF analysis was significant for increased leukocytes with monocyte predominance while protein and glucose values were within normal range. There was a hypercellular population of pleomorphic tumor cells with signet-ring morphology, similar to those seen in his diagnostic bladder biopsies. The signet-ring cells were positive for cytokeratin 7 and 20 and negative for CDX-2 and prostate-specific antigen. The patient's clinical condition rapidly deteriorated and he died less than a week after presentation. At autopsy, brain sections revealed signet ring cells in the meninges overlying the cerebrum, cerebellum, brainstem, spinal cord, and pituitary with superficial invasion of the brain parenchyma. No brain parenchymal lesions were present. This case illustrates a unique complication of primary bladder SRCC. Diagn. Cytopathol. 2017;45:73-76. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 85%

Section: Discussionmentioning

confidence: 85%

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Metastatic Signet‐Ring Cell Carcinoma of the Bladder in Cerebrospinal Fluid

Lin

Park

Gattuso

2016

Diagnostic Cytopathology

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“…SRC adenocarcinoma is rare. In consequence, it was virtually exclusively addressed in small‐scale, institutional case series . The exception consists of the study of Wang et al .…”

Section: Discussionmentioning

confidence: 99%

“…In consequence, it was virtually exclusively addressed in small-scale, institutional case series. 8,29,30 The exception consists of the study of Wang et al that relied on the SEER registry covering years 1973-2004, where authors identified 103 SRC patients of all stages, including those with distant metastases, who were exposed to a wide variety of treatment modalities, including RC in some. 11 In that study, SRC patients were younger, presented with a higher grade and stage compared with UC patients, and had significantly worse 3-year CSM-free rates after RC (33% vs 67%).…”

Section: Discussionmentioning

confidence: 99%

Contemporary rates of pathological features and mortality for adenocarcinoma of the urinary bladder in the USA

et al. 2016

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Primary signet-ring cell carcinoma of the bladder treated with laparoscopic radical cystectomy: a case report

Mukae,

Ohba,

Araki

et al. 2024

Int Canc Conf J

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Primary bladder adenocarcinomas comprise 0.5–2% of all epithelial bladder neoplasms. Of these, primary signet-ring cell carcinoma of the bladder is particularly rare, accounting for 0.24% of all bladder malignancies. This tumor is frequently diagnosed at an advanced stage and has a poor prognosis. No standard treatment has yet been established. We here report a patient in whom laparoscopic cystectomy following neoadjuvant chemotherapy was effective. Our patient was a 69-year-old man who had had microscopic hematuria, undergone transurethral resection of a mass in the bladder, and been diagnosed pathologically with a primary signet-ring cell carcinoma of the bladder. No metastases were detected on computed tomography. The patient was treated with a combination of paclitaxel, cisplatin, and gemcitabine prior to undergoing laparoscopic cystectomy. The histopathological diagnosis on this operative specimen was dysplasia and no metastases were detected in the dissected lymph nodes. Complete remission has now been maintained for 9 years.

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Metastatic signet-ring cell carcinoma of the urinary bladder: A novel management approach to a rare tumor.

Cited by 12 publications

References 14 publications

Metastatic Signet‐Ring Cell Carcinoma of the Bladder in Cerebrospinal Fluid

Metastatic Signet‐Ring Cell Carcinoma of the Bladder in Cerebrospinal Fluid

Contemporary rates of pathological features and mortality for adenocarcinoma of the urinary bladder in the USA

Primary signet-ring cell carcinoma of the bladder treated with laparoscopic radical cystectomy: a case report

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